ID F1NBA7_CHICK Unreviewed; 450 AA.
AC F1NBA7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Kremen protein {ECO:0000256|PIRNR:PIRNR036961};
DE AltName: Full=Kringle-containing protein marking the eye and the nose {ECO:0000256|PIRNR:PIRNR036961};
GN Name=KREMEN1 {ECO:0000313|Ensembl:ENSGALP00010035457.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010035457.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010035457.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010035457.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to
CC inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt
CC receptors LRP5 and LRP6. {ECO:0000256|PIRNR:PIRNR036961}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR036961};
CC Single-pass type I membrane protein {ECO:0000256|PIRNR:PIRNR036961}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR RefSeq; XP_015130967.1; XM_015275481.1.
DR AlphaFoldDB; F1NBA7; -.
DR SMR; F1NBA7; -.
DR STRING; 9031.ENSGALP00000009313; -.
DR PaxDb; 9031-ENSGALP00000009313; -.
DR Ensembl; ENSGALT00010058351.1; ENSGALP00010035457.1; ENSGALG00010023956.1.
DR GeneID; 416920; -.
DR KEGG; gga:416920; -.
DR CTD; 83999; -.
DR VEuPathDB; HostDB:geneid_416920; -.
DR GeneTree; ENSGT00940000158390; -.
DR InParanoid; F1NBA7; -.
DR OMA; SQHAGKP; -.
DR OrthoDB; 211181at2759; -.
DR Proteomes; UP000000539; Chromosome 15.
DR Bgee; ENSGALG00000005808; Expressed in skeletal muscle tissue and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00108; KR; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR017076; Kremen.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR24269; KREMEN PROTEIN; 1.
DR PANTHER; PTHR24269:SF13; KREMEN PROTEIN 1; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF01822; WSC; 1.
DR PIRSF; PIRSF036961; Kremen; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00130; KR; 1.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS51212; WSC; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR036961};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|PIRNR:PIRNR036961};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR036961};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR036961};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|PIRNR:PIRNR036961}.
FT TRANSMEM 370..392
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR036961"
SQ SEQUENCE 450 AA; 49890 MW; 7626195A7BEC00AC CRC64;
MEPPPLAAVV AFSGLALSCC REPVLSECYT ANGADYRGTQ NQTSQHAGKP CLFWNETFEH
PYNTLKYPNG EGGLGEHNYC RNPDGDVSPW CYIAEHEDGI YWKYCEIPSC RMPGNLGCYK
DHGEPPTLTG TSETSNKLTI QACISSCRSQ QFKFAGMESG YACFCGNNPD YWRYGEAAST
ECNSVCFGDH TQPCGGDGRV ILFDTLIGAC GGNYTSATAV IYSPDFPDTY GTGKVCYWTI
QVPGASQILF SFVLFEIKDA TDMVELLDGY TYHVLARFNG KNRPPHTFNI SLDFVILYFF
SDEINQAQGF AIRYRAVKDN VHQNKIAANQ TLSEKRNEHT NFSINAARSS KILYVITTSP
SHPSSSMPEW TIYSLTALLI LSVTAILAKI FLHVAMRSHQ IPPANETEDP SEVTAAGEIW
SIFYRPSTSI SIFKKQLRSQ QDDCNPLVGN
//
