ID   F1NEU3_CHICK            Unreviewed;       518 AA.
AC   F1NEU3;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN   Name=NPRL3 {ECO:0000313|Ensembl:ENSGALP00010028165.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010028165.1, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00010028165.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010028165.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC       inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
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DR   AlphaFoldDB; F1NEU3; -.
DR   Ensembl; ENSGALT00010047572.1; ENSGALP00010028165.1; ENSGALG00010019706.1.
DR   VEuPathDB; HostDB:geneid_416649; -.
DR   GeneTree; ENSGT00390000015916; -.
DR   Proteomes; UP000000539; Chromosome 14.
DR   Bgee; ENSGALG00000007456; Expressed in testis and 12 other cell types or tissues.
DR   ExpressionAtlas; F1NEU3; baseline and differential.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR   GO; GO:0035909; P:aorta morphogenesis; IEA:Ensembl.
DR   GO; GO:0048738; P:cardiac muscle tissue development; IEA:Ensembl.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR   GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR   GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|RuleBase:RU368069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Signal {ECO:0000256|RuleBase:RU368069}.
SQ   SEQUENCE   518 AA;  58538 MW;  17187AF508034144 CRC64;
     MSHCSSDPVL QLFSDVILAT ILATKSDMCG KKFELKIDNV RFVGHPTLLQ HALGQVSKTD
     PSPKREMPTM ILFNVVFALR ANADPSVINC LHNLSRRIAI VLQHEERRCQ YLTREAKLIL
     AIQDEVSAMS ETTEGPQSPF HHILPKCKLA RDLKETYDSL CTTGVVRLHI NNWLEVSFCL
     PHKIHYVATN FIPPEAIERS LKSIRPYHAL LLLNDEKSLL NELPLDCSPA LVRVIKTTSA
     VKNLQQLAQD ADLALLQVFQ LAAHLVYWGK AIIIYPLCEN NVYMLSPNAS VCLYSPLADA
     FSCQFRGHNL PSMLSKFSLP VSLSEFKNPL VPPVQETQLI QMVIWMLQHR LLIQLHTYVC
     LMVPPNEEEF RAQDEDMPFT ARVGGRSLST PNALSFGSPT SSDDMTLTSP SMDNSSAELI
     PGGDSPLNKR MTENLLASLL EHEREAILNV PAAQNPEDLR MFARLLHYFR GRHHLEEIMY
     NENMRRSQLL MLFDKFRSVL VVTSHEDPVI SVFQSLLK
//