ID F1NIM4_CHICK Unreviewed; 442 AA.
AC F1NIM4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=peptidylprolyl isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
DE EC=5.2.1.8 {ECO:0000256|PROSITE-ProRule:PRU00277};
GN Name=FKBP4 {ECO:0000313|Ensembl:ENSGALP00010037293.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010037293.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010037293.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010037293.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence={ECO:0000256|PROSITE-
CC ProRule:PRU00277};
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DR AlphaFoldDB; F1NIM4; -.
DR SMR; F1NIM4; -.
DR Ensembl; ENSGALT00010060534.1; ENSGALP00010037293.1; ENSGALG00010024793.1.
DR VEuPathDB; HostDB:geneid_418261; -.
DR GeneTree; ENSGT00940000157200; -.
DR OMA; FGAEGNE; -.
DR OrthoDB; 25281at2759; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000014331; Expressed in ovary and 12 other cell types or tissues.
DR ExpressionAtlas; F1NIM4; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005528; F:FK506 binding; IDA:AgBase.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.50.40; -; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46512; PEPTIDYLPROLYL ISOMERASE; 1.
DR Pfam; PF00254; FKBP_C; 2.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF54534; FKBP-like; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50059; FKBP_PPIASE; 2.
DR PROSITE; PS50005; TPR; 2.
PE 1: Evidence at protein level;
KW Isomerase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1NIM4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Rotamase {ECO:0000256|PROSITE-ProRule:PRU00277};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 312..345
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 346..379
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 442 AA; 50445 MW; ADA515D99B9E22CF CRC64;
MTAEEMKADG APLEGTDITP KRDEGVLKVV KREGTGTESP MIGDKVTVHY TGWLLDGTKF
DSSLDRRDKF SFDLGKGEVI KAWDIAVATM KVGEICQITC KPEYAYGLAG SPPKIPPNAT
LIFEIELFEF KGEDLTDDED GGIIRRIRKK GEGYLKPNEG ALVEIQFEGR YRDRAFDKRE
LRFEIGEGDN YDLPHGLEKA IQKMEKSEES IFYLKPNYGF GSTGKEKFQI PPDAELQYEV
KLKSFEKAKE SWEMNTEEKL EQSCMVKERG TQYFKEGKYK RAALQYKKIV LWLEHESGLS
DEEDTKAKSL RLAAHLNLAM CHLKLKEYSQ ALENCNKALE LDSSNEKGLF RRGEAHLAVN
DFELARGDFQ KVIQLYPSNK AAKVQLVTCQ QKIREQHEKE KKMYANMFQR LADKELKPAT
TLQTSHTEDA EMKDEQNGVD DK
//
