ID F1NL56_CHICK Unreviewed; 398 AA.
AC F1NL56;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 4.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=HS3ST3A1 {ECO:0000313|Ensembl:ENSGALP00010044839.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010044839.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010044839.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010044839.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR RefSeq; XP_015150740.1; XM_015295254.1.
DR AlphaFoldDB; F1NL56; -.
DR SMR; F1NL56; -.
DR STRING; 9031.ENSGALP00000002089; -.
DR Ensembl; ENSGALT00010072372.1; ENSGALP00010044839.1; ENSGALG00010029943.1.
DR GeneID; 769490; -.
DR KEGG; gga:769490; -.
DR CTD; 9955; -.
DR VEuPathDB; HostDB:geneid_769490; -.
DR GeneTree; ENSGT00940000162249; -.
DR InParanoid; F1NL56; -.
DR OMA; YFHSKMA; -.
DR OrthoDB; 10019at2759; -.
DR Reactome; R-GGA-2022928; HS-GAG biosynthesis.
DR Proteomes; UP000000539; Chromosome 18.
DR Bgee; ENSGALG00000001371; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0008467; F:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; IBA:GO_Central.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:Ensembl.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF7; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 3B1; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 146..381
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 155
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 155..159
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 236
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 244
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 361..365
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 344..356
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 398 AA; 43540 MW; 7A0719442D001B20 CRC64;
MAVSAAAAPA AEPLPRSIFK KFLVMLCSLL MSLYVFYCLA DRCQTLPGPI IAAGAASEEE
EGGGGGYLGG SAELPPWQAA AARRKRLLQR LKQRRRRQEA APGPEVPAGD GGSRAGGSGG
GGGGGSAAGT AGTLTLLLGE GSKRLPQAII IGVKKGGTRA LLEFLRVHPD VRAVGAEPHF
FDRNYERGLA WYRDLMPRTL EGQITMEKTP SYFVTKEAPA RISSMAKGTK LIVVVRDPVT
RAISDYTQTL SKKPDIPTFE SLTFKNRTTG LIDTSWSAIQ IGIYAKHLEN WLLYFPIGQI
LFVSGERLIS DPAGELGRVQ DFLGLKRIIT DKHFYFNKTK GFPCLKKAEG SSKPHCLGKT
KGRTHPDIDQ EVVQRLRDFY RPFNMKFYQM TGQDFGWD
//