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Database: UniProt
Entry: F1NLZ9_CHICK
LinkDB: F1NLZ9_CHICK
Original site: F1NLZ9_CHICK 
ID   F1NLZ9_CHICK            Unreviewed;      4947 AA.
AC   F1NLZ9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 3.
DT   22-NOV-2017, entry version 58.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGALP00000017561};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSGALP00000017561};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000017561, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000017561, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000017561,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000017561}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000017561};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGALP00000017561}.
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DR   EMBL; AADN04000071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9031.ENSGALP00000017561; -.
DR   PaxDb; F1NLZ9; -.
DR   Ensembl; ENSGALT00000017582; ENSGALP00000017561; ENSGALG00000010812.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F1NLZ9; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-GGA-2672351; Stimuli-sensing channels.
DR   Reactome; R-GGA-5578775; Ion homeostasis.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000010812; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:AgBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0008144; F:drug binding; IDA:AgBase.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4259   4277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4480   4500       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4554   4573       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4690   4711       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4748   4769       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4824   4847       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      105    160       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      167    212       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      220    275       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      281    338       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      346    403       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      606    804       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1020   1217       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1352   1557       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4002   4037       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4947 AA;  562746 MW;  70986A886A55FC4F CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCTATVHK EQQKLCLAAE GFGNRLCFLE STSNSKNVPP
     DLSICTFVLE QSLSVRALQE MLANTEEKAE GLVDVEKWSA QGGGHRTLLY GHAILLRHSY
     SGMYLCCLST SRSSMDKLAF DVGLQEDTTG EACWWTIHPA SKQRSEGEKV RVGDDLILVS
     VSSERYLHLS YGNGSLHVDA AFQQTLWSVA PISSGSEFAQ GYLIGGDVLR LLHGHMDECL
     TVPSGEHGEE QRRTVHYEGG AVSIHARSLW RLETLRVAWS GSHIRWGQPF RLRHITTGKY
     LSLLDDKSLL LTDKEKADIK STAFCFRSSK EKLDVGMRKE VDGMGTPEIK YGDSICFIQH
     VDTGLWLSYQ SADAKSVRMG SVQRKAIMHH EGHMDDGLTL SRSQHEESRT ARVIRSTVFL
     FNRFIRGLDA LSKKVKSSTV DLPIESVSLS LQDLIGYFHP PDEHLEHEDK QNRLRALKNR
     QNLFQEEGMI NLVLECIDRL NVYSSAAHFA DVAGKEAGEA WKSILNSLYE LLAALIRGNR
     KNCAQFSGSL DWLISRLERL EASSGILEVL HCVLVESPEA LNIIKEGHIK SIICLLDKHG
     RNHKVLDVLC SLCVCHGVAV RSNQHLICDN LLPGRDLLLQ TRLVNHVSSM RPNIFLGISE
     GSAQYRKWYY ELMVDHLEPF VTAESTHLRV GWASTEGYSP YPGGGAEWGG NGVGDDLYSY
     GFDGLHLWSG CVARTVNSPN QHLLRTEDVI SCCLDLSAPS ISFRINGQPV QGMFENFNID
     GLFFPVVSFS AGIKVRFLLG GRHGEFKFLP PPGYAPCFEA VLPKEKLKVE HSREYKQDRN
     YTRDLLGPTL NLSQAAFTPV PVDTSQIVLP PHLERIREKL AENIHELWVM NKIELGWQYG
     PVRDDNKRQH PCLVEFSKLP EQERNYNLQM SLETLKTLLA LGCHVGIADE RAEEKVKKMK
     LPKNYQLLSG YKPAPMDLSF IKLTPSQEAM VDKLAENAHN VWARDRIRQG WTYGIQQDVK
     NRRNPRLVPY ALLDDRTKKS NKDSLREAVR TLLGYGYNLE APDQDHATRV DMSNGIMEKF
     RIFRTEKTYA VKSGKWYFEF EAVTAGDMRV GWTRPGCLPD QELGSDEEAF VFDGFKAQRW
     HQGNEHFGRS WLAGDVVGCM VDMNEHTMMF TLNGEILLDD SGSELAFKDF EVGDGFLPVC
     SLGPSQVGRM NFGKDVSTLK YFTICGLQEG YEPFAVNTNR DITIWLSKRL PQFLPVPQNH
     EHIEVMRIDG TIDTCPCLKV TQKSFGSQNS KTDVMFFRLS MPIECAEVFS RTAAGGLPGT
     GLFGPKNDLE DYDADSDFEV LMKTAHGHLA ADRTEREKDA TKPELNNHKD YVQEKPSRLK
     QRFMLRRTKP DYSTSHSARL TEDVLADDRD DYDYLMQTST YYYSVRIFPG QEPANVWVGW
     ITSDFHQYDT SFDLDRVRTV TVTLGDEKGK VHESIKRSNC YMVCAGESMS PGQGRNNNGL
     EIGCLVDAAS GLLTFTANGK ELGTYYQVEP STKLFPAVFA QATSPNVFQF ELGRIKNVMP
     LSAGLFKSEH KNPVSQCPPR LHVQFLTHVL WSRVPNHFLK VDVSRISERQ GWMIQCLNPL
     QFMALHIPEE NRTIDILELT EQEELLKFHY HTLRLYSAVC ALGNNRVAHA MCSHVDESQL
     LYAIENKYMP GLLRAGYYDL LIDIHLNTYA TARLMMNNEF IVPMTDETKS ITLFPDENKK
     HGLPGIGLST SLRPRMQFSS PSFVSINSEC FQFSPEFPLE ILKAKTIEML TEAVQEGSLH
     VRDPVGGSTE FLFVPLIKLF YTLLIMGIFH NGDLKHILQL IEPRVFKEAA SLEDEKDLSE
     KELSSDELKS GEEESRGEQV PKEGLLQMKL PEPVKLQMCH LLQYLCDCQV RHRIEAIVAF
     SDDFVAKLQE NQRFRYNEVM QALNMSAALT ARKTKEFRSP PQEQINMLLN FKDDKTDCPC
     PEEIRDQLLD FHEDLMTHCG IELDEDGTLD GNSDLTIRGR LLYLVEKVTY LKKKQAEKPV
     DDDAKTSSTL QQLISDTMVR WAQESVIEDP ELVRAMFVLL HRQYDGIGGL VRALPKTYTI
     NSVSVEDTIN LLASLGQIRS LLSVRMGKEE EKLMIRGLGD IMNNKVFYQH PNLMRALGMH
     ETVMEVMVNV LGGGESKEIT FPKMVANCCR FLCYFCRISR QNQKAMFDHL SYLLENSSVG
     LASPSMRGST PLDVAAASVM DNNELALALR EPDLEKVVRY LAGCGLQSCP LLISKGYPDI
     GWNPVEGERY LDFLRFAVFC NGESVEENAN VVVRLLIRRP ECFGPALRGE GGNGLLAAME
     EAIQISEDPT RDGPSPNNGS SKTLEMEEQE DDTIHMGNAI MTFYAALIDL LGRCAPEMHL
     IHAGKGEAIR IRSILRSLIP LEDLVGVISI PFHMPTIAKD GTVVEPDMSA GFCPDHKAAM
     VLFLDRVYGI EDQDFLLHLL EVGFLPDLRA AASLDTAALS ATDMALALNR YLCTAVLPLL
     TRCAPLFAGT EHHASLIDSL LHTVYRLSKG CSLTKAQRDS IEECLLSICG QLRPSMMQHL
     LRRLVFDVPL LNEHAKMPLK LLTNHYERCW KYYCLPGGWG NFGAASEEEL HLSRKLFWGI
     FDALSQKKYE QELFKLALPC LSAVAGALPP DYMESNYVNM MEKQSSMDSD GNFNPQPVDT
     SNITIPEKLE YFINKYAEHS HDKWSMEKFA NGWTYGETYS ESAKVQPLMK QYKLLSEKEK
     EIYRWPIKES LKTMLAWGWR IERTREGDSM ALYNRTRRIS QTSQISVDAA HGYSPRAIDM
     SNVTLSRDVH AMAEMMAENY HNIWAKKKKM ELEAKGGGNH PLLVPYDTLT AKEKAKDREK
     AQDILKFLQI NGYVVSRGLK DLELDTPSIE KRFAYSFLQQ LIRYVDEAHQ YILEFDGGSR
     GKGEHFPYEQ EIKFFAKVVL PLIDQYFKNH RLYFLSAASR PLSTGGHASN KEKEMVTSLF
     CKLGVLVRHR ISLFGNDATS IVNCLHILGQ TLDARTVMKT GLESVKMALR AFLDNAAEDL
     EKTMENLKQG QFTHSRNQPK GVTQIINYTS VALLPVLSSL FEHIGQHQFG EDLILEDVQV
     SCYRILSSLY ALGTSKSIYV ERQRSALGEC LAAFSGAFPV AFLETHLNKH NIYSIYNTKN
     ARDRAVLNLP TSVEEVCPNI PSLVKLMEEI VELAESGIRY TQMPHIMEVI LPMLCSYMSH
     WWEHGPENNP DKVEVCCTAL TSEHMNTLLG NILKIIYNNL GIDEGAWMKR LAVFSQPIIS
     KAKPQLLKTH FLPLMDKLKK KAAVVVSDEE HLRAEGRGDM SEAELLILDE FTTLARDLYA
     FYPLLIRFVD YNRAKWLKEP NPEAEELFRM VAEVFIYWSK SHNFKREEQN FVVQNEINNM
     SFLISDTKSK MSKAAVSDQE RKKMKRKGDR YSMQTSLIVA ALKRLLPIGL NICAPGDQDL
     IALAKNRFSM KDTEDEVRDI IRSNLHLQGK LEDPAIRWQM ALYKDLPNRT EDSSDPEKTV
     ERVLDIANVL FHLEQVRDIF PIVEHPQRSK KAVWHKLLSK QRKRAVVACF RMAPLYNLPR
     HRAVNLFLQG YDKSWIETEE HYFEDKLIED LAKPGEEPQE EDESLKRVDP LHQLILLFSR
     TALTEKCKCF LFACYQSCHD EEDDDGEEEV KSFEEKEMEK QKLLYQQARL HDRGAAEMVL
     QTISASKGEM GPMVAATLKL GIAILNGGNS TVQQKMLDYL KDKKDVGFFQ SLAGLMQSCS
     VLDLNAFERQ NKAEGLGMVT EEGSGEKVMQ DDEFTCDLFR FLQLLCEGHN SDFQNYLRTQ
     TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDVIDEQ GQRNFSKAIQ VAKQVFNTLT
     EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF AHMQMKLSQD SSQIELLKEL MDLQKDMVVM
     LLSMLEGNVV NGTIGKQMVD MLVESSNNVE MILKFFDMFL KLKDLTSSDA FKEYDPDGKG
     IISKRDFHKA MESHKHYTQS ETEFLLSCAE TDENETLDYE EFVKRFHEPA KDIGFNVAVL
     LTNLSEHMPH DTRLQTFLEL SESVLNYFQP FLGRIEIMGS AKRIERVYFE ISESSRTQWE
     KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ LAAQISESDL NERSANKEDN
     EKDKLEEQDP GMGFFSLVTM KSALVALKYN LMTLMKMLSV KSLKKQMKKV KKMTMKDMVM
     ALFSSYWSIL MGLLHFACSV FRGFFRIICS LLLGGSLVEG AKKIKVAELL ANMPDPTQDE
     VRGEGEEGER KPAETALPTE DLTDLRTLSE ESDLLSDIFG LDLKREGGQY KLIPHNPNAG
     LSDLLSTPSV APMPEAQEKV QDQVKEDEKE EKEETKSEPE KAEGEDGEKE EKAKEDRAKQ
     KLRQLHTHRY GEPEIQESAF WKKIIAYQQK LLNYFARNFY NMRMLALFVA FAINFILLFY
     KVSTSAVTEE KEIPVVSTGE NMKLDSLESD SQRVIAVHYV LEESSGYMEP TLRILAILHT
     VISFFCIIGY YCLKVPLVIF KREKEVARKL EFDGLYITEQ PSEDDIKGQW DRLVINTQSF
     PNNYWDKFVK RKVMDKYGEF YGRDRISELL GMDKAALDFS DAREKKKPKK DSSLSAVLNS
     IDVKYQMWKL GVVFTDNSFL YLAWYMTMSV LGHYNNFFFA AHLLDIAMGF KTLRTILSSV
     THNGKQLVLT VGLLAVVVYL YTVVAFNFFR KFYNKSEDGD MPDMKCDDML TCYMFHMYVG
     VRAGGGIGDE IEDPAGDEYE IYRIIFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV
     KEDMETKCFI CGIGNDYFDT VPHGFETHTL QEHNLANYLF FLMYLINKDE TEHTGQESYV
     WKMYQERCWE FFPAGDCFRK QYEDQLN
//
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