UniProt: F1NQL9

Database: UniProt
Entry: F1NQL9_CHICK

LinkDB:  F1NQL9_CHICK 
Original site:  F1NQL9_CHICK

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Ontology (15)   
   GO (15)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (22)   
   InterPro (12)   
   Pfam (2)   
   PROSITE (5)   
   SMART (3)   
All databases (44)   

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ID   F1NQL9_CHICK            Unreviewed;      2311 AA.
AC   F1NQL9;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE            EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN   Name=ROS1 {ECO:0000313|Ensembl:ENSGALP00010017222.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010017222.1, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00010017222.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010017222.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171,
CC         ECO:0000256|RuleBase:RU000312};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000312}.
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DR   RefSeq; NP_990588.2; NM_205257.2.
DR   SMR; F1NQL9; -.
DR   Ensembl; ENSGALT00010029602.1; ENSGALP00010017222.1; ENSGALG00010012360.1.
DR   GeneID; 396192; -.
DR   KEGG; gga:396192; -.
DR   CTD; 6098; -.
DR   VEuPathDB; HostDB:geneid_396192; -.
DR   GeneTree; ENSGT00940000160831; -.
DR   InParanoid; F1NQL9; -.
DR   OMA; LPQINWS; -.
DR   OrthoDB; 4577877at2759; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000014913; Expressed in colon and 2 other cell types or tissues.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0002066; P:columnar/cuboidal epithelial cell development; IEA:Ensembl.
DR   GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0010966; P:regulation of phosphate transport; IEA:Ensembl.
DR   GO; GO:0032006; P:regulation of TOR signaling; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd00063; FN3; 7.
DR   CDD; cd05044; PTKc_c-ros; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   PANTHER; PTHR24416:SF527; PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 9.
DR   SMART; SM00135; LY; 3.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 5.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF63825; YWTD domain; 3.
DR   PROSITE; PS50853; FN3; 8.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Kinase {ECO:0000256|ARBA:ARBA00023137};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transferase {ECO:0000256|ARBA:ARBA00023137};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000312};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
SQ   SEQUENCE   2311 AA;  260928 MW;  E64B055ABFE1D3C1 CRC64;
     MRNACLLLNR LGAFYFIWIS AAYCSFSKNC QDLCTSNLEG ELGIANLCNV SDINVACTQG
     CQFWNATEQV NCPLKCNKTY TRECETVSCK FGCSRAEDAY GVEAQNCLNK PGAPFASSIG
     SHNITLGWKP ANISEVKYII QWKFHQLPGD WRYTEVVSET SYTVKDLQAF TEYEFRVVWI
     ITSQLQLHSP PSPSYRTHAS GVPTTAPIIK DIQSSSPNTV EVSWFPPLFP NGLIVGYNLV
     LTSENHELLR ASRGHSFQFY STFPNSTYRF SIVAVNEAGA GPPAEANITT PESKVKEKAK
     WLFLSRNQSL RKRYMEHFLE AAHCLQNGII HHNITGISVN VYQQVVYFSE GNSIWVKGVV
     DMSDVSDLTL FYTGWGNITS ISVDWLYQRM YFVMNEKIHV CQLENCTAAE DITPPYVTSP
     RKIVADPYNG YIFCLLEDGI YRANLPLFPD TASAASLVVK SHTLRDFMIN FQSKRLIFFN
     KTEQAFVSGF LDGSEFHTLR AHVPLDDMES FVYEDNIFTV TDGRAVFHEE ISQVGSSSFN
     EYVVDCSLEY PEYFGFGNLL FYAASTQPYP LPTLPRLVTV LFGSDQAVIS WSPPEYTIGT
     SRSAWQNWTY DVKVSSQSTF EEEWVVSNIT DTRFAVKNLV SFTEYEMSVR AVSPAGEGPW
     SEPFRGMTFE EAEEEPYILA VGAEGLWKQR LDSYGPGEFL YPHIRNISDL DWYNDTLYWS
     NSMGKVQTWS MNKKEGTTEN SYVPDIKNAR MLAFDWLGQC LYWAGKANTI YRKSLLGDHM
     DVVAHVVYVV KDLAVDSVNG YLYWATTYTV ESARLNGEEY LILQEHLQFS GKQVVGLALD
     LTSGFLYWLV QDGLCLNLYR ISICKESCGN IMVTEISAWS VSEVSQNALQ YYSGRLFWIN
     RLKFITTQEL NQSISIPFSE PAEFAAFTLV HTSLKPLPGN FSFTPKVIPS SVPESSFKIK
     GNSSSFHIIW NASTDVQWGT VFYCVGSNAL QMRTLESERC LHPHDLTVPS YKVDWLEPFT
     LFDFSVTPYT YWGKAPTTSV YLRAPEGVPS APANPRIYVL HSNTHEGEEK VLVELRWDKP
     ERDNGVLTQF RVYYQLLYES GAADTLMEWN VSDVKPTALL FSIRDVHPRL TVRFQVQAFT
     SVGPGPMSDV AQRNSSDIFP VPTLITFSSN KLFLTDIDSN HTIWEVLTNR NIKDICYTAD
     DDKVYYILED SLFLLNVQST SESQLFEDVF LRNVTAITVD WIARHLFVAM KTSWNETQVF
     FIDLELKTKS LKALNIQLGK RNSTISSLLS YPFLSRLYWI EELDYGSRMF YYDILNNTMY
     HILGYESVEE KMRNYCNCNV AEAELGRPIS IDVTDIKKPQ LLFIRGRDEI WASDVDGCHC
     WRITKIPSFQ GTKIGSLTVD KQFIYWTIEK KEYTEICLAD KESTRHSLQR KANHELKILA
     YSSAMQSYPD KKCLTPLLDT EKPTILDTTN TSFTLSLPSV TTQQLCPSIS QPTPTYLVFF
     REITSNHENS TYHFSTLLQK TLEIQEPIAV INNLKPFSSY AIQVAVKNYY SNQNQLAVGR
     ETISTTLYGV PEGVDSIKTV VLSDTTINIS WSEPLEPNGP LESIRYQISV NLLSLFPEAP
     LRKSEFPNGT LSWSVSDLQS GTNNLFKVLA FHPNENWFSE SVPVIAKTFE TPLSPSNIIP
     RNTSFQLEWR APLHINGTSF WFELRKWQTR SDWFSPASTT CTVGPVYTCN LTGTLPSANY
     LVRATVVYVT GMKSTSSPTS FKTTAGVPSK PGTPKRAEDS KNSVQWEKAE DNGSNLTYYI
     LESRKQSGNT NKVKSLWVVV YNGSCDSICT WKAENLEGTF QFRAAAANML GLGEYSDTSK
     DIVLAKDTVT SPDITAIVAV IGAVVLGLTI IILFGFVWHQ RWKSRKPAST GQIVLVKEDK
     ELAQLRGMAE TVGLANACYA VSTLPSQAEI ESLPAFPRDK LNLHKLLGSG AFGEVYEGTA
     LDILADGSGE SRVAVKTLKR GATDQEKSEF LKEAHLMSKF DHPHILKLLG VCLLNEPQYL
     ILELMEGGDL LSYLRGARKQ KFQSPLLTLT DLLDICLDIC KGCVYLEKMR FIHRDLAARN
     CLVSEKQYGS CSRVVKIGDF GLARDIYKND YYRKRGEGLL PVRWMAPESL IDGVFTNHSD
     VWAFGVLVWE TLTLGQQPYP GLSNIEVLHH VRSGGRLESP NNCPDDIRDL MTRCWAQDPH
     NRPTFFYIQH KLQEIRHSPL CFSYFLGDKE SVAGFINQAF EDIDVPPADS DSILSTTLME
     ARDQEGLNYL VVVKESNQDQ GSISSAELTS V
//

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