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Database: UniProt
Entry: F1NXH0_CHICK
LinkDB: F1NXH0_CHICK
Original site: F1NXH0_CHICK 
ID   F1NXH0_CHICK            Unreviewed;      2357 AA.
AC   F1NXH0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 3.
DT   28-MAR-2018, entry version 52.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSGALP00000039311};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000039311, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000039311, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000039311,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000039311}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000039311};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; AADN04000034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGALT00000040102; ENSGALP00000039311; ENSGALG00000008456.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000000539; Chromosome 17.
DR   Bgee; ENSGALG00000008456; -.
DR   ExpressionAtlas; F1NXH0; baseline and differential.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     89    106       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    215    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    500    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    526    543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    625    647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    703    725       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1169   1188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1208   1229       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1241   1259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1302   1324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1414   1439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1495   1513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1525   1551       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1557   1577       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1619   1646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1706   1730       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1868   1902       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      354    374       {ECO:0000256|SAM:Coils}.
FT   COILED      734    761       {ECO:0000256|SAM:Coils}.
FT   COILED     1021   1044       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2357 AA;  266577 MW;  741223CDFEB2A112 CRC64;
     MARFGDDLPT RYGGGGPAGA GRGSSRQGGP QAGQRMYKQS MAQRARTMAL YNPIPVKQNC
     FTVNRSLFIF SEDNVIRKYA KRITEWPPFE YMILATIIAN CIVLALEQHL PDGDKTPMSE
     RLDDTEPYFI GIFCFEAGIK IIALGFVFHK GSYLRNGWNV MDFVVVLTGI LATAGTDFDL
     RTLRAVRVLR PLKLVSGIPS LQVVLKSIMK AMVPLLQIGL LLFFAIVMFA IIGLEFYMGK
     FHKTCFSNET GEEVGDFPCG EEPPARQCES GTTCREYWQG PNYGITNFDN ILFAVLTVFQ
     CITMEGWTDI LYNTNDAAGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF AKERERVENR
     RAFLKLRRQQ QIERELNGYL EWIFKAEEVM LAEEDKNAEE KSPLDGRAAS EGPIQQGTAP
     AETSSGSSYN MLKRAAIKKS KNDLIHAEEG EDHFTDICSV GSPFARASLK SGKNESSSYF
     RRKEKMFRFF IRRMVKAQSF YWIVLCVVAL NTLCVAMVHY DQPEKLTTAL YFAEFVFLGL
     FLTEMSLKMY GLGPRNYFHS SFNCFDFGVI VGSIFEVIWA AVKPGTSFGI SVLRALRLLR
     IFKVTKYWNS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ FNFRDETPTT
     NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVHSGMF SSIYFIVLTL FGNYTLLNVF
     LAIAVDNLAN AQELTKDEEE MEEATNQKLA LQKAKEVAEV SPMSAANISI AAKQQNSSKS
     KSVWEQRTSQ IRMHNFRASC EALYNELDPE ERVRYATTLH IRPDMKTHLD RPLVVEPRGE
     GRNNISKLSP VDVQEVEQTK VSSTDGAEAP RKHHRHRDKE KLGEQEKGDV TKDENGESGI
     NNKEERHRQH RSRSKEVEGG SKEGKSDRSR GQEGGKRHHR RGSVEEGVEK EHRRHRTHRH
     SAERQGKEGN GTINGARSER RTRHRGGSRS GNREGEPGSK GENGEEPHRR HRFRSRALST
     YDSVEKENRE KEGETAEKEH QNHQPKENQC EIEASGSVSI PVHTLPSTYL QKVPEQPEDA
     DNQKNVTRMI QPPLDKTTTV NIPVTITAPP GETTVIPMNN VEFESKTEEK KDVDDLTKNG
     PKPILPYSSM FILSPTNPIR RLFHYIVNLR YFEMVILIVI ALSSIALAAE DPVQAESPRN
     DALKYLDYIF TGVFTFEMVI KMIDLGLLLH PGSYFRDLWN ILDFIVVSGA LVAFAFSGTK
     GKDINTIKSL RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA
     VQLFKGRFFY CTDESKELEK DCRGQYLDYE KNEVEAQPRE WKKYEFHYDN VLWALLTLFT
     VSTGEGWPTV LKHSVDATYE EQGPSPGYRM EMSIFYVVYF VVFPFFFVNI FVALIIITFQ
     EQGDKVMSEC SLEKNERACI DFAISAKPLT RYMPQNKQSF QYKMWKFVVS PPFEYFIMVM
     IALNTIVLMM KFYDAPEAYE EMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF
     VTVLGSITDI LVTEIAVKDN FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP
     YVCLLIAMLF FIYAIIGMQV FGNIALNDET SINRHNNFRT FLQALMLLFR SATGEAWHEI
     MLSCLSNRAC DPLSGLTKNE CGSEFAYFYF VSFIFLCSFL MLNLFVAVIM DNFEYLTRDS
     SILGPHHLDE FVRVWAEYDP AACCRIHYKD MYNLLRVIAP PLGLGKKCPH RVAYKRLVRM
     NMPISPEDLT VHFTSTLMAL IRTALEIKLA SGGVKQHQCD AELRKEISLV WPNLSQKTLD
     LLVPPHKPDE MTVGKVYAAL MIFDFYKQNK NSREQVHQPP GGLCQPGPVS LFHPLKATLE
     QTQPSAFSSA KAFLRQKSSA SLNNGGTLPA PEGGIKESSS WGTQRTQDVF YETRTPAFER
     GHSEEIPIER VVEMREISPT LANGEHQPGL ESQGRAASMP RLAAETQRSK ARSPGSYLAP
     IPDTSPMKRS ISTLTPQRPH PMHLYEYSLE RVPTDQVHHH HHHRCHRRKE KKQKSLDRTT
     HQLADGEAVA QSGESSSKDK KQERGRSQER KQHSSSSSEK QRFYSCDRYG SRDRSQPKSA
     DQSRPTSPNG GPEQGPHRQG SGSVNGSPLL STSGASTPCR GRRQLPQTPL TPRPSITYKT
     ANSSPVHFST SPGGLPPFSP GRLSRGLSEH NALLRGDQQP PPAAVARIGS DPYLGHRDAA
     DSPIGAAPED TLTFEEAVAT NSGRSSRTSY VSSLTSQSHQ ARRVPNGYHY TLGLNTGPGT
     GTRGRSYYHE ADEDDWC
//
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