ID F1NXL4_CHICK Unreviewed; 567 AA.
AC F1NXL4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Protein kinase AMP-activated non-catalytic subunit gamma 2 {ECO:0000313|Ensembl:ENSGALP00010040065.1};
GN Name=PRKAG2 {ECO:0000313|Ensembl:ENSGALP00010040065.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010040065.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010040065.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010040065.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1
CC or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic
CC subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
CC {ECO:0000256|ARBA:ARBA00025878}.
CC -!- SIMILARITY: Belongs to the 5'-AMP-activated protein kinase gamma
CC subunit family. {ECO:0000256|ARBA:ARBA00006750}.
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DR RefSeq; NP_001265071.1; NM_001278142.1.
DR AlphaFoldDB; F1NXL4; -.
DR SMR; F1NXL4; -.
DR STRING; 9031.ENSGALP00000010021; -.
DR Ensembl; ENSGALT00010065799.1; ENSGALP00010040065.1; ENSGALG00010027135.1.
DR GeneID; 420435; -.
DR CTD; 51422; -.
DR VEuPathDB; HostDB:geneid_420435; -.
DR GeneTree; ENSGT00950000183019; -.
DR InParanoid; F1NXL4; -.
DR OMA; XVQIYEL; -.
DR OrthoDB; 880743at2759; -.
DR Reactome; R-GGA-1632852; Macroautophagy.
DR Reactome; R-GGA-163680; AMPK inhibits chREBP transcriptional activation activity.
DR Reactome; R-GGA-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR Reactome; R-GGA-5628897; TP53 Regulates Metabolic Genes.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000006219; Expressed in spermatid and 12 other cell types or tissues.
DR ExpressionAtlas; F1NXL4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0031588; C:nucleotide-activated protein kinase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016208; F:AMP binding; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR CDD; cd04618; CBS_euAMPK_gamma-like_repeat1; 1.
DR CDD; cd04641; CBS_euAMPK_gamma-like_repeat2; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR PANTHER; PTHR13780:SF122; 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-2; 1.
DR PANTHER; PTHR13780; AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT; 1.
DR Pfam; PF00571; CBS; 3.
DR SMART; SM00116; CBS; 4.
DR SUPFAM; SSF54631; CBS-domain pair; 2.
DR PROSITE; PS51371; CBS; 4.
PE 1: Evidence at protein level;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1NXL4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 273..333
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 355..415
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 428..490
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 502..560
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 567 AA; 62841 MW; CE1D7E3D161E9AF7 CRC64;
MGSTAMDTKK KDSSGSGRRG SSQKKLMLRV HIPDLSSFAM PFLDGDVENT DKNASRKVEE
SYSAGSPSKG IFSKGLQNRP SSPVSAPVRS KHSPGSPKTV FPFPYQESPP RSPRRMSFSG
IFRSSSKESS PNSNPSTSPG GIKFFSRSRK TSGLSSSPST PTQVTKQPTF PLESYKHEPE
RLETRIHCSS PPDTGQRFSL PPSQSAAKPP IMTPSPCATS KPAAAAAPAP SQLPAASEGM
LEKLELEDEA LEESESDIYV RFMRSHKCYD IVPTSSKLVV FDTTLQVKKA FFALVANGVR
AAPLWESKKQ SFVGMLTITD FINILHRYYK SPMVQIYELE EHKIETWREL YLQETFKPLV
NISPDASLFD AVYSLIKNKI HRLPVIDPVS GNALYILTHK RILKFLQLFM SEMPKPAFMK
KNLDELGIGT YHNIAFIHPD TPIIKALNIF VERRISALPV VDESGKVVDI YSKFDVINLA
AEKTYNNLDI TVTQALQHRS QYFEGVVKCS MLETLETIVD RIVKAEVHRL VVVNEADSIV
GIISLSDILQ ALVLTPAGAK QKENESE
//
