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Database: UniProt
Entry: F1NY22_CHICK
LinkDB: F1NY22_CHICK
Original site: F1NY22_CHICK 
ID   F1NY22_CHICK            Unreviewed;      2332 AA.
AC   F1NY22;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 4.
DT   25-OCT-2017, entry version 45.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSGALP00000039303};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000039303, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000039303, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000039303,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000039303}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000039303};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGALP00000039303}.
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DR   EMBL; AADN04000034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F1NY22; -.
DR   Ensembl; ENSGALT00000040094; ENSGALP00000039303; ENSGALG00000008456.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000000539; Chromosome 17.
DR   Bgee; ENSGALG00000008456; -.
DR   ExpressionAtlas; F1NY22; baseline and differential.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035500; NHR_like_domain.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     89    106       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    215    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    475    495       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    501    518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    600    622       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    678    700       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1144   1163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1183   1204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1216   1234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1277   1299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1389   1414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1470   1488       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1500   1526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1532   1552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1594   1621       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1681   1705       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1843   1877       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      709    736       {ECO:0000256|SAM:Coils}.
FT   COILED      996   1019       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2332 AA;  264139 MW;  0C41D104CD2F5240 CRC64;
     MARFGDDLPT RYGGGGPAGA GRGSSRQGGP QAGQRMYKQS MAQRARTMAL YNPIPVKQNC
     FTVNRSLFIF SEDNVIRKYA KRITEWPPFE YMILATIIAN CIVLALEQHL PDGDKTPMSE
     RLDDTEPYFI GIFCFEAGIK IIALGFVFHK GSYLRNGWNV MDFVVVLTGI LATAGTDFDL
     RTLRAVRVLR PLKLVSGIPS LQVVLKSIMK AMVPLLQIGL LLFFAIVMFA IIGLEFYMGK
     FHKTCFSNET GEEVGDFPCG EEPPARQCES GTTCREYWQG PNYGITNFDN ILFAVLTVFQ
     CITMEGWTDI LYNTNDAAGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF AKERERVENR
     RAFLKLRRQQ QIERELNGYL EWIFKAEEVM LAEEDKNAEE KSPLDVLKRA AIKKSKNDLI
     HAEEGEDHFT DICSVGSPFA RASLKSGKNE SSSYFRRKEK MFRFFIRRMV KAQSFYWIVL
     CVVALNTLCV AMVHYDQPEK LTTALYFAEF VFLGLFLTEM SLKMYGLGPR NYFHSSFNCF
     DFGVIVGSIF EVIWAAVKPG TSFGISVLRA LRLLRIFKVT KYWNSLRNLV VSLLNSMKSI
     ISLLFLLFLF IVVFALLGMQ LFGGQFNFRD ETPTTNFDTF PAAILTVFQI LTGEDWNAVM
     YHGIESQGGV HSGMFSSIYF IVLTLFGNYT LLNVFLAIAV DNLANAQELT KDEEEMEEAT
     NQKLALQKAK EVAEVSPMSA ANISIAAKQQ NSSKSKSVWE QRTSQIRMHN FRASCEALYN
     ELDPEERVRY ATTLHIRPDM KTHLDRPLVV EPRGEGRNNI SKLSPVDVQE VEQTKVSSTD
     GAEAPRKHHR HRDKEKLGEQ EKGDVTKDEN GESGINNKEE RHRQHRSRSK EVEGGSKEGK
     SDRSRGQEGG KRHHRRGSVE EGVEKEHRRH RTHRHSAERQ GKEGNGTING ARSERRTRHR
     GGSRSGNREG EPGSKGENGE EPHRRHRFRS RALSTYDSVE KENREKEGET AEKEHQNHQP
     KENQCEIEAS GSVSIPVHTL PSTYLQKVPE QPEDADNQKN VTRMIQPPLD KTTTVNIPVT
     ITAPPGETTV IPMNNVEFES KTEEKKDVDD LTKNGPKPIL PYSSMFILSP TNPIRRLFHY
     IVNLRYFEMV ILIVIALSSI ALAAEDPVQA ESPRNDALKY LDYIFTGVFT FEMVIKMIDL
     GLLLHPGSYF RDLWNILDFI VVSGALVAFA FSGTKGKDIN TIKSLRVLRV LRPLKTIKRL
     PKLKAVFDCV VNSLKNVLNI LIVYMLFMFI FAVIAVQLFK GRFFYCTDES KELEKDCRGQ
     YLDYEKNEVE AQPREWKKYE FHYDNVLWAL LTLFTVSTGE GWPTVLKHSV DATYEEQGPS
     PGYRMEMSIF YVVYFVVFPF FFVNIFVALI IITFQEQGDK VMSECSLEKN ERACIDFAIS
     AKPLTRYMPQ NKQSFQYKMW KFVVSPPFEY FIMVMIALNT IVLMMKFYDA PEAYEEMLKC
     LNIVFTSMFS MECVLKIIAF GVLNYFRDAW NVFDFVTVLG SITDILVTEI AVKDNFINLS
     FLRLFRAARL IKLLRQGYTI RILLWTFVQS FKALPYVCLL IAMLFFIYAI IGMQVFGNIA
     LNDETSINRH NNFRTFLQAL MLLFRSATGE AWHEIMLSCL SNRACDPLSG LTKNECGSEF
     AYFYFVSFIF LCSFLMLNLF VAVIMDNFEY LTRDSSILGP HHLDEFVRVW AEYDPAACCR
     IHYKDMYNLL RVIAPPLGLG KKCPHRVAYK RLVRMNMPIS PEDLTVHFTS TLMALIRTAL
     EIKLASGGVK QHQCDAELRK EISLVWPNLS QKTLDLLVPP HKPDEMTVGK VYAALMIFDF
     YKQNKNSREQ VHQPPGGLCQ PGPVSLFHPL KATLEQTQPS AFSSAKAFLR QKSSASLNNG
     GTLPAPEGGI KESSSWGTQR TQDVFYETRT PAFERGHSEE IPIERVVEMR EISPTLANGE
     HQPGLESQGR AASMPRLAAE TQRSKARSPG SYLAPIPDTS PMKRSISTLT PQRPHPMHLY
     EYSLERVPTD QVHHHHHHRC HRRKEKKQKS LDRTTHQLAD GEAVAQSGES SSKDKKQERG
     RSQERKQHSS SSSEKQRFYS CDRYGSRDRS QPKSADQSRP TSPNGGPEQG PHRQGSGSVN
     GSPLLSTSGA STPCRGRRQL PQTPLTPRPS ITYKTANSSP VHFSTSPGGL PPFSPGRLSR
     GLSEHNALLR GDQQPPPAAV ARIGSDPYLG HRDAADSPIG AAPEDTLTFE EAVATNSGRS
     SRTSYVSSLT SQSHQARRVP NGYHYTLGLN TGPGTGTRGR SYYHEADEDD WC
//
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