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Database: UniProt
Entry: F1NZV1_CHICK
LinkDB: F1NZV1_CHICK
Original site: F1NZV1_CHICK 
ID   F1NZV1_CHICK            Unreviewed;      2735 AA.
AC   F1NZV1;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 3.
DT   20-DEC-2017, entry version 60.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSGALP00000013491};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSGALP00000013491};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000013491, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000013491, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000013491,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000013491}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000013491};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGALP00000013491}.
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DR   EMBL; AADN04000009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9031.ENSGALP00000013490; -.
DR   PaxDb; F1NZV1; -.
DR   Ensembl; ENSGALT00000013506; ENSGALP00000013491; ENSGALG00000008294.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OrthoDB; EOG091G00T2; -.
DR   Reactome; R-GGA-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-GGA-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-GGA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-GGA-418457; cGMP effects.
DR   Reactome; R-GGA-5578775; Ion homeostasis.
DR   Reactome; R-GGA-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000000539; Chromosome 12.
DR   Bgee; ENSGALG00000008294; -.
DR   GO; GO:0005955; C:calcineurin complex; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031088; C:platelet dense granule membrane; IEA:Ensembl.
DR   GO; GO:0031094; C:platelet dense tubular network; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0019855; F:calcium channel inhibitor activity; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR   GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR   GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0050882; P:voluntary musculoskeletal movement; IEA:Ensembl.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 4.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2257   2279       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2291   2309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2315   2341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2377   2402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2423   2445       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2556   2579       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      135    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      196    246       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      254    310       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      317    396       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      402    458       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1616   1636       {ECO:0000256|SAM:Coils}.
FT   COILED     2673   2714       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2735 AA;  311653 MW;  178520A49E2F36B0 CRC64;
     MEKSFYLISS NVSLYSSRGS KPEMTDKMSS FLHIGDICSL YAEGSTNGFI STLGLVDDRC
     VVQPEAGDLN NPPKKFRDCL FKLCPMNRYS AQKQFWKAAK PGANSTTDAV LLNKLHHAAD
     LEKKQNETEN RKLLGTVIQY GNVIQLLHLK SNKYLTVNKR LPALLEKNAM RVTLDEAGNE
     GSWFYIQPFY KLRSIGDSVV IGDKVVLNPV NAGQPLHASS HQLVDNPGCN EVNSVNCNTS
     WKIVLFMKWS DNKDDILKGG DVVRLFHAEQ EKFLTCDEHR KKQHVFLRTT GRQSATSATS
     SKALWEVEVV QHDPCRGGAG YWNSLFRFKH LATGHYLAAE VNPDYEEDDQ ECQSSQDPEQ
     DASRRGLRSA QEKMAYSLVS VPEGNDISSI FELDPTTLRG GDSLVPRNSY VRLRHLCTNT
     WVHSTNIPID KEEEKPVMLK IGTSPVKEDK EAFAIVPVSP AEVRDLDFAN DASKVLGSIA
     GKLEKGTITQ NERRSVTKLL EDLVYFVTGG TNSGQDVLEV VFSKPNRERQ KLMREQNILK
     QIFKLLQAPF TDSGDGPMLR LEELGDQRHA PFRHICRLCY RVLRHSQQDY RKNQEYIAKQ
     FGFMQKQIGY DVLAEDTITA LLHNNRKLLE KHITAAEIDT FVSLVRKNRE PRFLDYLSDL
     CVSMNKSIPV TQELICKAVL NPANADILIE TKLVLSRFEF EEVSSGENAL EVGEDEEEVW
     LFWRDSNKEI RSKSIRELAQ DAKEGQKEDR DVLSYYRYQL NLFARMCLDR QYLAINEISG
     QLDVDLILRC MSDENLPYDL RASFCRLMLH MHVDRDPQEQ VTPVKYARLW SEIPSEIAID
     DYDSSGTSKD EIKERFAQTM EFVEEYLRDV VCQRFPFSDK EKNKLTFEVV NLARNLIYFG
     FYNFCDLLRL TKILLAILDC VHITTIFPIT KMAKGEESKG SNVMRSIHGV GELMTQVVLR
     GGGFLPMTPL AAAPEGNVKQ TEPEKEDILV MDTKLKIIEI LQFILNVRLD YRISCLLCIF
     KHEFDESNAQ MSESPTGSSS QEMPANVPGA LDFEHIEEQA EGIFGGSEEN TPLDLDDHGG
     RTFLRVLLHL TMHDYPPLVS GALQLLFRHF SQRQEVLQAF KQVQLLVTSQ DVDNYKQIKQ
     DLDQLRSIVE KSELWVYKGQ GPDETMDGVP GENEHKKKEE GHSKSQKPES TSSYNYRVVK
     EILLRLSKLC VQESASVRKS RKQQQRLLRN MGAHAVVLEL LQIPYEKAED TRMQEIMKLA
     HEFLQNFCAG NQQNQALLHK HINLFLNPGI LEAVTMQHIF MNNFQLCSEI NERVVQHFVH
     CIETHGRNVQ YIKFLQTIVK AEGKFIKKCQ DMVMAELVNA GEDVLVFYND RASFQTLVQM
     MRSERDRMDE NSPLMYHIHL VELLAVCTEG KNVYTEIKCN SLLPLDDIVR VVTHEDCIPE
     VKIAYINFLN HCYVDTEVEM KEIYTSNHMW KLFENFLVDI CRACNNTSDR KHADSILEKY
     VTEIVMSIVT TFFSSPFSDQ STTLQTRQPV FVQLLQGVFR VYHCNWLMPS QKASVESCIR
     VLSDVAKSRA IAIPVDLDSQ VNNLFLKSHN IVQKTAMNWR MTARNAARRD SVLAASRDYR
     NIIERLQDIV SALEDRLRPL VQAELSVLVD VLHRPELLFP ENTDARRKCE SGGFICKLIK
     HTKQLLEENE EKLCIKVLQT LREMMTKDRG YGEKGEALRQ VLVNRYYGNV RPAGRRESLT
     SFGNGPLSAG STGKAGAGGG SSGSSSMSRG EMSLADVQCH LDKEGASNLV IDLIMNATSD
     RVFHESILLA IALLEGGNTT IQHSFFCRLT EDKKSEKFFK VFYDRMKVAQ QEIKATVTVN
     TSDLGNKKKD EDSDRDVPNR KRVREPMTQI TEEVRDQLLE ASAATRKAYS TYRREADSDD
     HYSAAEGAQS AADKSKDDLE MSAVISIMQP ILRFLQLLCE NHNRDLQNFL RCQNNKTNYN
     LVCETLQFLD CICGSTTGGL GLLGLYINEK NVALINQTLE SLTEYCQGPC HENQNCIATH
     ESNGIDIITA LILNDINPLG KKRMDLVLEL KNNASKLLLA IMESRHDSEN AERILYNMRP
     KELVEVIKKA YLQGEVEFED GENGEDLAAS PRNVGHNIYI LAHQLARHNK ELQNMLKPGG
     QIEGDEALEF YAKHTAQIEI VRSDRTMEQI VFPVPNICEF LTKESKLRIY YTTERDEQGS
     KINDFFMKSE DLFNEMNWQK KLRAQPFLYW CARNMSFWSS ISFNLAVLMN LLVAFFYPFK
     GIRGGTLEPH LSGLLWTAML ISLAIVIALP KPHGIRALIA STILRLIFSV GLQPTLFLLG
     AFNVCNKIIF LMSFVGNCGT FTRGYKAMIM DVEFLYHLLY LLICALGLFV HEFFYSLLLF
     DLVYREETLL NVIKSVTRNG RSIILTAVLA LILVYLFSIV GYLFFKDDFI LEVDKLPNET
     LLPDRTEPGE TMTGEFLYSD VCKAGSSENC SSIIPSDQLI AEEMEEENKE HTCETLLMCI
     VTVLSHGLRS GGGVGDVLRK PSKEEPLFAA RVIYDLLFFF MVIIIVLNLI FGVIIDTFAD
     LRSEKQKKEE ILKTTCFICG LERDKFDNKT VTFEEHIKEE HNMWHYLCFI VLVKVKDSTE
     YTGPESYVAE MIKERNLDWF PRMRAMSLVS SDSDGEQNEL RNLQEKLEST MKLVTNLSGQ
     LSELKDQMTE QRKQKQRIGL LGHPPPMNVN PQQPA
//
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