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Database: UniProt
Entry: F1PAH2_CANLF
LinkDB: F1PAH2_CANLF
Original site: F1PAH2_CANLF 
ID   F1PAH2_CANLF            Unreviewed;      2469 AA.
AC   F1PAH2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   27-SEP-2017, entry version 51.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1E {ECO:0000313|Ensembl:ENSCAFP00000019238};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000019238, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000019238, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000019238,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000019238}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000019238};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000019238}.
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DR   EMBL; AAEX03005131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03005132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03005133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03005134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9615.ENSCAFP00000019238; -.
DR   PaxDb; F1PAH2; -.
DR   Ensembl; ENSCAFT00000020724; ENSCAFP00000019238; ENSCAFG00000013004.
DR   eggNOG; ENOG410INF5; Eukaryota.
DR   eggNOG; ENOG410YD06; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; F1PAH2; -.
DR   OMA; RRRHHMS; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Reactome; R-CFA-422356; Regulation of insulin secretion.
DR   Proteomes; UP000002254; Chromosome 7.
DR   Bgee; ENSCAFG00000013004; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF253; PTHR10037:SF253; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    276    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    308    326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    367    386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    441    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    474    496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    623    643       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    649    667       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    749    771       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    826    849       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1298   1317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1370   1389       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1435   1457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1547   1572       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1628   1646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1658   1681       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1687   1705       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1752   1770       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1845   1869       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1885   1920       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      845    872       {ECO:0000256|SAM:Coils}.
FT   COILED     1243   1270       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2469 AA;  278231 MW;  04F402DD37D47A19 CRC64;
     MVPEMRGPSP GRRLPEPAPC PAAAGSPEPW AAGRRRHVLA LPEEEAWRPQ QCSLLEADAS
     DEVGMLPASP RAAASGVDNF FPVQEGEGAG WEGGAALDAG AGPFLPVSPE VMKRRRGGLI
     EQRDIIKAHE AHKMQSTPQA RRKEWEMARF GEAVVGRPGS GDGDSDQSRN RQGTPVPASG
     PAAAYKQSKA QRARTMALYN PIPVRQNCFT VNRSLFIFGE DNIVRKYAKK LIDWPPFEYM
     ILATIIANCI VLALEQHLPE DDKTPMSRRL EKTEPYFIGI FCFEAGIKIV ALGFIFHKGS
     YLRNGWNVMD FIVVLSGILA TAGTHFNTHV DLRTLRAVRV LRPLKLVSGI PSLQIVLKSI
     MKAMVPLLQI GLLLFFAILM FAIIGLEFYS GKLHRACFTN NSGILEGFDP PHPCGVQGCP
     AGYECRDWIG PNDGITQFDN ILFAVLTVFQ CITMEGWTTV LYNTNDALGA TWNWLYFIPL
     IIIGSFFVLN LVLGVLSGEF AKERERVENR RAFMKLRRQQ QIERELNGYR AWIDKAEEVM
     LAEENKNAGT SALEVLRRAT IKRSRTEAMT RDSSDEHCVD ISSVGTPLAR ASIKSAKVDG
     ASYFRHKERL LRISIRHMVK SQVFYWIVLS LVALNTACVA IVHHNQPQWL THLLYYAEFL
     FLGLFLLEMS LKMYGMGPRL YFHSSFNCFD FGVTVGSIFE VVWAIFRPGT SFGISVLRAL
     RLLRIFKITK YWASLRNLVV SLMSSMKSII SLLFLLFLFI VVFALLGMQL FGGRFNFNDG
     TPSANFDTFP AAIMTVFQIL TGEDWNEVMY NGIRSQGGVS SGMWSAIYFI VLTLFGNYTL
     LNVFLAIAVD NLANAQELTK DEQEEEEAFN QKHALQKAKE VSPMSAPNMP SIERDRRRRH
     HMSMWEPRSS HLRERRRRHH MSVWEQRTSQ LRRHMQMSSQ EALNKEEAPP MNPLNPLNPL
     SPLNPLNAHP SLYRRPRPIE GLGLGLEKCE EERIISRGGS LKGDGGDLSS ALDNQRSPLS
     LGKREPPWLA RPCHGNCDPT QQEAGGGETV VTFEDRARHR QSQRRSRHRR VRTEGKELSS
     TSRSRSVSQE RSLDEGVLTD GEKEREPRGG HAGKEPTIQE EDRGQDLRRT NSLMVPRGSG
     LAGALDEANT PLVLPHHDLE VGKDTVLTEQ EPEGSSEQAL LGDVQLDIGR VISQSEPDLS
     CVTANTDKAT TDSTSVTVAI PDVGPLMDST VIHISNKTDG EASPLKEAEI KEEEEEMEKK
     QQKKEKRETG KAMVPHSSMF IFSTTNPIRR ACHYIVNLRY FEMCILLVIA ASSIALAAED
     PVLTNSERNK VLRYFDYVFT GVFTFEMVIK MIDQGLILQD GSYFRDLWNI LDFVVVVGAL
     VAFALANALG TNKGRDIKTI KSLRVLRVLR PLKTIKRLPK LKAVFDCVVT SLKNVFNILI
     VYKLFMFIFA VIAVQLFKGK FFYCTDSSKD TEKECIGNYV DHEKNKMEVK GREWKRHEFH
     YDNIIWALLT LFTVSTGEGW PQVLQHSVDV TEEDRGPSRS NRMEMSIFYV VYFVVFPFFF
     VNIFVALIII TFQEQGDKMM EECSLEKNER ACIDFAISAK PLTRYMPQNR HTFQYRVWHF
     VVSPSFEYTI MAMIALNTVV LMMKYYSAPC TYELALKYLN IAFTMVFSLE CVLKIIAFGF
     LNYFRDTWNI FDFITVIGSI TEIILTDSKL VNTSGFNMSF LKLFRAARLI KLLRQGYTIR
     ILLWTFVQSF KALPYVCLLI AMLFFIYAII GMQVFGNIKL DEESHINRHN NFRSFFGSLM
     LLFRSATGEA WQEIMLSCLG EKGCEPDTTA PSGQNENERC GTDLAYVYFV SFIFFCSFLM
     LNLFVAVIMD NFEYLTRDSS ILGPHHLDEF VRVWAEYDRA ACGRIHYTEM YEMLTLMSPP
     LGLGKRCPSK VAYKRLVLMN MPVAEDMTVH FTSTLMALIR TALDIKIAKG GADRQQLDSE
     LQKETLAIWP HLSQKMLDLL VPMPKASDLT VGKIYAAMMI MDYYKQSKVK KQRQQLEEQK
     NAPMFQRMEP SSLPQEIIAN AKALPYLQQD PVSGLSGRSG YPSMSPLSPQ EIFQLACMDP
     ADDGQFQEHQ SLEPEVSELK SVQSSNHGIY LPSDTQEHTG SGRASSMPRL TVDPQVVTDT
     SSMRRSFSTI RDKRSNSSWL EEFSMERSSE NTYKSRRRSY HSSLRLSAHR LNSDSGHKSD
     THRSGGRERG RSKERKHLLS PDVSRCNSEE RGTQADWESP ERQQSRSPSE ARSQTPNRQG
     TGSLSESSIP SISDTSTPRR SRRQLPPVPP KPRPLLSYSS LIRHSGSISP PADGSERGSP
     LTPQALESTE AGLAEPSGPR HGHGQGHGQG HGQQSQHCSP QRYISEPYLA LHEDSHASDC
     GEEETLTFEA AVATSLGRSN TIGSAPPLRH SWQMPNGHYR RRRRGGPGPG VMCGAVSDLL
     SDTEEDDKC
//
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