GenomeNet

Database: UniProt
Entry: F1PEE8_CANLF
LinkDB: F1PEE8_CANLF
Original site: F1PEE8_CANLF 
ID   F1PEE8_CANLF            Unreviewed;      4960 AA.
AC   F1PEE8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   25-OCT-2017, entry version 55.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCAFP00000014764};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSCAFP00000014764};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000014764, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000014764, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000014764,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000014764}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000014764};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000014764}.
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DR   EMBL; AAEX03002669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03002670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03002671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03002672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9615.ENSCAFP00000014764; -.
DR   iPTMnet; F1PEE8; -.
DR   PaxDb; F1PEE8; -.
DR   Ensembl; ENSCAFT00000015962; ENSCAFP00000014764; ENSCAFG00000010034.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F1PEE8; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-CFA-2672351; Stimuli-sensing channels.
DR   Reactome; R-CFA-5578775; Ion homeostasis.
DR   Proteomes; UP000002254; Chromosome 4.
DR   Bgee; ENSCAFG00000010034; -.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IDA:BHF-UCL.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0044325; F:ion channel binding; IPI:BHF-UCL.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IDA:BHF-UCL.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IDA:BHF-UCL.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4273   4292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4493   4513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4567   4586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4703   4724       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4761   4782       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4837   4860       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       95    150       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      157    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      584    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1010   1207       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1322   1547       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4016   4051       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4405   4429       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4960 AA;  563895 MW;  A09E47E30C028B6E CRC64;
     RMMKWFCSVP QPSTKNNRSC VWQQKALATD FVSWSPLQIP RMFLQTSPSA PLCWNSLSLS
     GPCKRCWLTL WRSQKGQVLN LSFLFSTQTA QGGGHRTLLY GHAILLRHSY SGMYLCCLST
     SRSSTDKLAF DVGLQEDTTG EACWWTIHPA SKQRSEGEKV RVGDDLILVS VSSERYLHLS
     YGNGSLHVDA AFQQTLWSVA PISSGSEAAQ GYLIGGDVLR LLHGHMDECL TVPSGEHGEE
     QRRTVHYEGG AVSVHARSLW RLETLRVAWS GSHIRWGQPF RLRHVTTGKY LSLMEDKSLL
     LMDKENADVK STAFTFRSSK EKLDVGVRKE VDGMGTSEIK YGDSVCYIQH INTGLWLTYQ
     SVDVKSVRMG SIQRKAIMHH EGHMDDGLNL SRSQHEESRT ARVIRSTVFL FNRFIRGLDA
     LSKKVRASTV DLPIESVSLS LQDLIGYFHP PDEHLEHEDK QNRLRALKNR QNLFQEEGMI
     NLVLECIDRL HVYSSAAHFA DVAGREAGES WKSILNSLYE LLAALIRGNR KNCAQFSGSL
     DWLISRLERL EASSGILEVL HCVLVESPEA LNIIKEGHIK SIISLLDKHG RNHKVLDVLC
     SLCVCHGVAV RSNQHLICDN LLPGRDLLLQ TRLVNHVSSM RPNIFLGVSE GSAQYKKWYY
     ELMVDHTEPF VTAEATHLRV GWASTEGYSP YPGGGEEWGG NGVGDDLFSY GFDGLHLWSG
     CIARTVSSPN QHLLKTDDVI SCCLDLSAPS ISFRINGQPV QGMFENFNID GLFFPVVSFS
     AGIKVRFLLG GRHGEFKFLP PPGYAPCYEA VLPKEKLKVE HSREYKQERT YTRDLLGPTV
     SLTQAAFTPI PVDTSQIVLP PHLERIREKL AENIHELWVM NKIELGWQYG PVRDDNKRQH
     PCLVEFSKLP EQERNYNLQM SLETLKTLLA LGCHVGISDE HAEEKVKKMK LPKNYQLTSG
     YKPAPMDLSF IKLTPSQEAM VDKLAENAHN VWARDRIRQG WTYGIQQDVK NRRNPRLVPY
     TLLDDRTKKS NKDSLREAVR TLLGYGYNLE APDQDHAARA EVCSGTGERF RIFRAEKTYA
     VKAGRWYFEF EAVTAGDMRV GWSRPGCQPD QELGSDEHAF AFDGFKAQRW HQGNEHYGRS
     WQAGDVVGCM VDMTERTMMF TLNGEVLLDD SGSELAFKDF DVGDGFIPVC SLGVAQVGRM
     NFGKDVSTLK YFTICGLQEG YEPFAVNTNR DITMWLSKRL PQFLQVPSNH EHIEVTRIDG
     TIDSSPCLKV TQKSFGSQNS STDIMFYRLS MPIECAEVFS KTVAGGLPGT GLFGPKNDLE
     DYDADSDFEV LMKTAHGHLV PDRVDKDKEA TKPEFNNHKD YAQEKPSRLK QRFLLRRTKP
     DYSTSHSARL TEDVLADDRD DYDYLMQTST YYYSVRIFPG QEPANVWVGW ITSDFHQYDT
     GFDLDRVRTV TVTLGDEKGK VHESIKRSNC YMVCAGESMS PGQGRNNNGL EIGCVVDAAS
     GLLTFTANGK ELSTYYQVEP STKLFPAVFA QATSPNVFQF ELGRIKNVMP LSAGLFKSEH
     KNPVPQCPPR LHVQFLSHVL WSRMPNQFLK VDVSRISERQ GWLVQCLDPL QFMSLHIPEE
     NRSVDILELT EQEELLKFHY HTLRLYSAVC ALGNHRVAHA LCSHVDEPQL LYAIENKYMP
     GLLRAGYYDL LIDIHLSSYA TARLMMNSEF IVPMTEETKS ITLFPDENKK HGLPGIGLST
     SLRPRIQFSS PSFVSINNEC YQYSPEFPLD ILKAKTIQML TEAVKEGSLH ARDPVGGTTE
     FLFVPLIKLF YTLLIMGIFH NEDLKHILQL IEPSVFKEAA TPDEETEALE KEPCPEDSKS
     EGAGEEEAKG VKRPKEGLLQ MKLPEPVKLQ MCLLLQYLCD CQVRHRIEAI VAFSDDFVAK
     LQDNQRFRYN EVMQALNMSA ALTARKTKEF RSPPQEQINM LLNFKDDKSE CPCPEEIRDQ
     LLDFHEDLMT HCGIELDEDG SLDGNSDLTI RGRLLSLVEK VTYLKKKQAE KPIESDSKKS
     STLQQLISET MVRWAQESVI EDPDLVRAMF VLLHRQYDGI GGLVRALPKT YTINGVSVED
     TINLLASLGQ IRSLLSVRMG KEEEKLMIRG LGDIMNNKVF YQHPNLMRAL GMHETVMEVM
     VNVLGGGESK EITFPKMVAN CCRFLCYFCR ISRQNQKAMF DHLSYLLENS SVGLASPAMR
     GSTPLDVAAA SVMDNNELAL ALREPDLEKV VRYLAGCGLQ SCQMLVSKGY PDIGWNPVEG
     ERYLDFLRFA VFCNGESVEE NANVVVRLLI RRPECFGPAL RGEGGNGLLA AMEEAIKIAE
     DPSRDGPSPT SGSSKTLDTE EEEDDTIHMG NAIMTFYSAL IDLLGRCAPE MHLIHAGKGE
     AIRIRSILRS LIPLGDLVGV ISIAFQMPTI AKDGNVVEPD MSAGFCPDHK AAMVLFLDRV
     YGIEVQDFLL HLLEVGFLPD LRAAASLDTA ALSATDMALA LNRYLCTAVL PLLTRCAPLF
     AGTEHHASLI DSLLHTVYRL SKGCSLTKAQ RDSIEVCLLS ICGQLRPSMM QHLLRRLVFD
     VPLLNEHAKM PLKLLTNHYE RCWKYYCLPG GWGNFGAASE EELHLSRKLF WGIFDALSQK
     KYEQELFKLA LPCLSAVAGA LPPDYMESNY VSMMEKQSSM DSEGNFNPQP VDTSNITIPE
     KLEYFINKYA EHSHDKWSMD KLANGWIYGE IYSDSSKVQP LMKPYKLLSE KEKEIYRWPI
     KESLKTMLAW GWRIERTREG DSMALYNRTR RISQTSQVSV DAAHGYSPRA IDMSNVTLSR
     DLHAMAEMMA ENYHNIWAKK KKMELESKGG GNHPLLVPYD TLTAKEKAKD REKAQDILKF
     LQINGYAVSR GFKDLELDTP SIEKRFAYSF LQQLIRYVDE AHQYILEFDG GGRSKGEHFP
     YEQEIKFFAK VVLPLIDQYF KNHRLYFLSA ASRPLCSGGH ASNKEKEMVT SLFCKLGVLV
     RHRISLFGND ATSIVNCLHI LGQTLDARTV MKTGLESVKS ALRAFLDNAA EDLEKTMENL
     KQGQFTHTRN QPKGVTQIIN YTTVALLPML SSLFEHIGQH QFGEDLILED VQVSCYRILT
     SLYALGTSKS IYVERQRSAL GECLAAFAGA FPIAFLETHL DKHNIYSIYN TKSSRERAAL
     NLPTNVEDVC PNIPSLEKLM EEIVELAESG IRYTQMPHVM EVILPMLCSY MSRWWEHGPE
     NNPERAEMCC TALNSEHMNT LLGNILKIIY NNLGIDEGAW MKRLAVFSQP IINKVKPQLL
     KTHFLPLMEK LKKKAAMVVS EEDHLKAEAR GDMSEAELLI LDEFTTLARD LYAFYPLLIR
     FVDYNRAKWL KEPNPEAEDL FRMVAEVFIY WSKSHNFKRE EQNFVVQNEI NNMSFLITDT
     KSKMSKAAVS DQERKKMKRK GDRYSMQTSL IVAALKRLLP IGLNICAPGD QELIALAKNR
     FSMKDTEDEV RDIIRSNIHL QGKLEDPAIR WQMALYKDLP NRTEDTSDPE KTVERVLDIA
     NVLFHLEQVR FCIPFIILPQ VEHPQRSKKA VWHKLLSKQR KRAVVACFRM APLYNLPRHR
     AVNLFLQGYE KSWIETEEHY FEDKLIEDLA KPGADPPEEE ESTKRVDPLH QLILLFSRTA
     LTEKCKLEED FLYMAYADIM AKSCHDEEDD DGEEEVKSFE VTGSQRSKEK EMEKQKLLYQ
     QARLHDRGAA EMVLQTISAS KGDTGPMVAA TLKLGIAILN GGNSTVQQKM LDYLKEKKDV
     GFFQSLAGLM QSCSVLDLNA FERQNKAEGL GMVTEEGSGE KVLQDDEFTC DLFRFLQLLC
     EGHNSDFQNY LRTQTGNNTT VNIIISTVDY LLRVQESISD FYWYYSGKDV IDEQGQRNFS
     KAIQVAKQVF NTLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMQMK LSQDSSQIEL
     LKELMDLQKD MVVMLLSMLE GNVVNGTIGK QMVDMLVESS NNVEMILKFF DMFLKLKDLT
     SSDTFKEYDP DGKGVISKRD FHKAMESHKH YTQSETEFLL SCAETDENET LDYEEFVKRF
     HEPAKDIGFN VAVLLTNLSE HMPNDTRLQT FLELAESVLN YFQPFLGRIE IMGSAKRIER
     VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEKEKME LFVNFCEDTI FEMQLAAQIS
     ESDLNERSVS KEESEKEKPE EQGPRMGFFS ILTVKSALLA LRYNVLTLMR MLSLKSLKKQ
     MKRVKKMTVK DMVMAAFSSY WNIFMSLLHF VASVSRGFFR IICSLLLGGS LVEGAKKIRV
     AELLANMPDP TQDEVRGDSE EGDRKPMEAA LPSEDLTDLK ELTEESDLLS DIFGLDLKRE
     GGQYKLIPHN PNAGLSDLMS NPVPIPDVQE KFQEQKAKEE EKEEKEENKS EPEKAEGEDG
     EKEEKAKEDK GKQKLRQLHT HRYGEPEVPE SAFWKKIIAY QQKLLNYFAR NFYNMRMLAL
     FVAFAINFIL LFYKVSTSSV VEGKELSTRS SSENAKVSSL DSGSPRIITV HYVLEESSGY
     MEPTLRILAI LHTVISFFCI IGYYCLKVPL VIFKREKEVA RKLEFDGLYI TEQPSEDDIK
     GQWDRLVINT QSFPNNYWDK FVKRKVMDKY GEFYGRDRIS ELLGMDKAAL DFSDAREKKK
     PKKDSSLSAV LNSIDVKYQM WKLGVVFTDN SFLYLAWYMT MSILGHYNNF FFAAHLLDIA
     MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DGDTPDMKCD
     DMLTCYMFHM YVGVRAGGGI GDEIEDPAGD EYEIYRIIFD ITFFFFVIVI LLAIIQGLII
     DAFGELRDQQ EQVKEDMETK CFICGIGNDY FDTVPHGFET HTLQEHNLAN YLFFLMYLIN
     KDETEHTGQE SYVWKMYQER CWEFFPAGDC FRKQYEDQLN
//
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