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Database: UniProt
Entry: F1PF06_CANLF
LinkDB: F1PF06_CANLF
Original site: F1PF06_CANLF 
ID   F1PF06_CANLF            Unreviewed;      1689 AA.
AC   F1PF06;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   25-OCT-2017, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSCAFP00000017137};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000017137, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000017137, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000017137,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000017137}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000017137};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000017137}.
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DR   EMBL; AAEX03017734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9615.ENSCAFP00000017137; -.
DR   PaxDb; F1PF06; -.
DR   Ensembl; ENSCAFT00000018504; ENSCAFP00000017137; ENSCAFG00000011648.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F1PF06; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002254; Chromosome 36.
DR   Bgee; ENSCAFG00000011648; -.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    123    142       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    241    263       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    374    397       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    505    528       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    540    561       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    573    591       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    634    653       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    712    732       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    975    993       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1005   1022       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1064   1086       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1172   1199       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1257   1275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1287   1305       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1312   1331       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1376   1404       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1480   1506       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      123    406       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      510    734       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      746    932       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      938   1203       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1257   1506       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      414    441       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1689 AA;  193958 MW;  8114FBCD6CAB8A50 CRC64;
     MVASRKLEMA SREPKGLVPF TRESLEFMKQ HIAKKHSEEQ RDLTPNTDLE VGKELPFAYG
     NLPQGMVLEP LEDVDPYYKN KNTFMVLNKS RTIFRFNATW CTFSPFSSTR RTTIKILVHP
     PTFFRLFILI SVLIDCIFMS MTEMPKWGPV LQNTLLGIYT FEILIKLIAR GIWVEPFYFF
     GDPWNWLDFS VTLFEHITRY LPLYFIPIFR ISRNLRILKI IPLNQGLRSF VGILIHCLKK
     LTGVITLTLF FLSVFSLIGM GLFMGNLKHK CLRWPQENET ATLHNKTGNP YYIRETENFY
     YLEGENSALL CGNRTDAGQC PEGYVCVKAG TNPDYGFTNF DTFGWALLAM FRLMTQDYPE
     ALYHQILYAS GKVYMIFFVV ISFWFAFYIA SLFLGILAKS CEEEKLKTKA RKVEPKFQQT
     LKELQERNEA AETNATQIEM KKRSPTSIIT SLNMLDDAAA AIRHEEELKK SRKRCPSCWY
     RCTKTFLIWN CSPCWLKLKE FIHMIIMDPF TDLVLAICII LNICFLALDS YPMSEETKNV
     LSIGNLICVG IFTAEMILKI IAMHPYGYFQ VGWNIFDSLI VFHGLAEFYL ANIHGLAPFR
     TFRVLRIFKL VKYWPTFKIL MQILNDSLVA LKDLVLLLLT FTFFSAVVGL KLFGMNYKEG
     VCNIDKDCRL PHWHMQDFFH SYLNVFRILC GEWIETLWDC FKVAGQFSCI PFYMMVILIG
     NLLIIYLFLA LVSSFSSYKA ATTEEDDEAK NLQRAVAKIQ KGINYVLSKI LCKNQNVSKE
     TMDNVNDVYV KENISDHTLS ELSNTQEFLK DKEKSSGTEK NTLSENESQS LIPSPSVSET
     VPIASGESDI ENLDNKEIQS KSGDGSSKEK VKQSSSSECS TVDIAISEEE EMVYEHEKPK
     HLKNGYRQRS SPGQFSRVSR KGKIWQNIRK TCCKIVENSC FKCFIGLVTL LSTGALAFED
     IYIDQRKTIK ILLEYADMIF TYIFILEMLL KWMAYGFKAY FTNGWYKLDF MVVIVFCLSL
     IGKSREELKP LISIKFLRAL RVLSQFERMK VVVRALIKTT LPTLNVFLVC FMIWLAFSIL
     GVHLFAGTFY ECIDPTSGER FPIAEVMNKS QCESLVFNES MPWENAKLNF DNVGNGFLSL
     LQVATFNGWI TIMNSAVDSI GVNRQPNFED NIYMYCYFIN FVIIGLFLPL SMLIGVIIAN
     FNKHNIKQGG SNIFITVKQK KQSRALRRLL CEDSQKTLRR PGNKCQGFIF DLVTNDIFNA
     IIMVLICFQA ITIMIQSDEQ SQKMDAALCW INLVLIILYA GECVLKLIAF QCSYFTIGWN
     IFDFMVVIFS VTDQELFLPM MVGYYLVSPS IVELIRMSRI IHILRPGKGP KVFHDLLLPL
     ILSLPALLNI SLLIFLVMFI YAIFGMYNFA YVKKEAGIND VSNFETFGSS MLCLFQVTIF
     AGWDGMLNAI FNSKWSDCDP DKINPGTQVR GDCGNPSVGI IYFVSYIIIS WLIIVNMYIV
     VVMEFLNIAS KKKAKTLSED DFRKFFQVWE QFDPDKTQYI DSSMLSDFAA ALDPPLFMAK
     PNKGQLVAMD LPMAAGDRIH CLDILLALTK RVMGKDVKME KIISEMESGF VLANPFKITY
     EPITTTLKRK QEAVSATIIQ RAYKSYRLRQ NDKNTSDIHM IDEDKEVQAN TENAYFDKAE
     EKSTIQSQI
//
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