GenomeNet

Database: UniProt
Entry: F1PIS0_CANLF
LinkDB: F1PIS0_CANLF
Original site: F1PIS0_CANLF 
ID   F1PIS0_CANLF            Unreviewed;      5058 AA.
AC   F1PIS0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   30-AUG-2017, entry version 50.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSCAFP00000008828};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSCAFP00000008828};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000008828, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000008828, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000008828,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000008828}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000008828};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000008828}.
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DR   EMBL; AAEX03000974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03000975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9615.ENSCAFP00000008828; -.
DR   PaxDb; F1PIS0; -.
DR   Ensembl; ENSCAFT00000009509; ENSCAFP00000008828; ENSCAFG00000005896.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F1PIS0; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-CFA-2672351; Stimuli-sensing channels.
DR   Reactome; R-CFA-5578775; Ion homeostasis.
DR   Proteomes; UP000002254; Chromosome 1.
DR   Bgee; ENSCAFG00000005896; -.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF97; PTHR13715:SF97; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4342   4359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4581   4601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4669   4692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4858   4880       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4939   4962       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    266       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      272    329       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      337    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      583    799       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1015   1210       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1359   1572       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1871   1925       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5058 AA;  566577 MW;  ED57CBF3B6B711D1 CRC64;
     MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFVLE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HTHSGMYLSC
     LTTSRSMTDK LAFDVGLQED ATGEACWWTA HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ VDASFMQTLW NMNPICSGCE EGYVTGGHVL RLFHGHMDEC LTISPADSED
     QRSRLVHYEG GSVCTHARSL WRLEPLRISW SGSHLRWGQP LRIRHVTTGR YLALTEDQGL
     VVVDASKAHT KATSFCFRIS KEKLDMAPKR DVDGMGPPEI KYGESLCFVQ HVASGLWLTY
     AAPDPKALRL GVLKKKAMLH QEGHMDDALS LTRCQQEESQ AARMIYSTAG LYNQFIKGLD
     SFSGKPRGSG PPAGTALPIE GVILSLQDLI GYFEPPSEEL QHEEKQSKLR SLRNRQSLFQ
     EEGMLSLVLN CIDRLNVYTT AAHFAEFAGE EAAESWKEIV NLLYELLASL IRGNRSNCAL
     FSTNLDWLVS KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV
     LDVLCSLCVC NGVAVRSNQD LITENLLPGR ELLLQTNLIN YVTSIRPNIF VGRAEGSTQY
     GKWYFEVMVD EVAPFLTAQA THLRVGWALT EGYSPYPGGG EGWGGNGVGD DLYSYGFDGL
     HLWTGHVARL VTSPGQHLLA PEDVVSCCLD LSVPSISFRI NGCPVQGVFE AFNLDGLFFP
     VVSFSAGVKV RFLLGGRHGE FKFLPPPGYA PCHEAVLPRE RLHLEPIKEY RREGPRGPHL
     VGPSRCLSHT DFVPCPVDTV QIVLPPHLER IREKLAENIH ELWALTRIEQ GWTYGPVRDD
     NKRLHPCLVD FHSLPEPERN YNLQMSGETL KTLLALGCHV GMADEKAEDN LKKTKLPKTY
     MMSNGYKPAP LDLSHVRLTP AQMTLVDRLA ENGHNVWARD RVAQGWSYSA VQDIPARRNP
     RLVPYRLLDE ATKRSNRDSL CQAVRTLLGY GYNIEPPDQE PSQVESQSRW DRVRIFRAEK
     SYTVQSGRWY FEFEAVTTGE MRVGWARPEL RPDVELGADE LAYVFNGHRG QRWHLGSEPF
     GRPWQSGDVV GCMIDLTENT IIFTLNGEVL MSDSGSETAF REIEVGDGFL PVCSLGPGQV
     GHLNLGQDVS SLRFFAICGL QEGFEPFAIN MQRPVTTWFS KSLPQFEAVP LEHPHYEVAR
     VDGTVDTPPC LRLSHRTWGS QNSLVEMLFL RLSLPVQFHQ HFRCTAGATP LAPPGLQPPA
     EDEARAAEPD PDYENLRRSA GRWGEAEGGK EGNAKEGAPG GNAQAGVEAQ PVRVENEKDA
     TTEKNKKRGF LFKAKKAAMM TQPPATPTLP RLPREVVPAD NRDDPEIILN TTTYYYSVRI
     FAGQEPSCVW VGWVTPDYHQ HDMNFDLSKV RAVTVTMGDE QGNVHSSLKC SNCYMVWGGD
     FVSSGQQGRI SHTDLVIGCL VDLATGLMTF TANGKESNTF FQVEPNTKLF PAVFVLPTHQ
     NVIQFELGKQ KNIMPLSAAM FLSERKNPAP QCPPRLEVQM LMPVSWSRMP NHFLQVETRR
     AGERLGWAVQ CQEPLTMMAL HIPEENRCMD ILELSERLDL QRFHSHTLCL YRAVCALGNN
     RVAHALCSHV DQAQLLHALE DAHLPGPLRA GYYDLLISIH LESACRSRRS MLSEYIVPLT
     QETRAITLFP PGKSAENGPR RHGLPGVGVT TSLRPPHHFS PPCFVAALPA AGVTEAPARL
     SPSIPLEALR DKALRMLGEA VRDGGQHARD PVGGSVEFQF VPVLKLVSTL LVMGIFADED
     VKQILKMIEP EVFTEEEEEE EEEEEEEEDE EEKEEDEEEE AQEKEDEEKE EEETAEGEKE
     EDLEEGLLQM KLPESVKLQM CHLLEYFCDQ ELQHRVESLA AFAERYVDKL QANQRDRYGL
     LMKAFTMSAA ETARRTREFR SPPQEQINML LHFKDGEDEE DCPLPEEVRQ DLLEFHQDLL
     AHCGIQLEGE EEEPEEEATL GSRLMSLLEK VRLVKKKEEK PEEESPAEES KPQSLQELVS
     HTVVRWAQED FVQSPELVRA MFSLLHRQYD GLGELLRALP RAYTISPSSM EDTMSLLECL
     GQIRSLLIVQ MGPQEENLMI QSIGNIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGE
     SKEIRFPKMV TSCCRFLCYF CRISRQNQRS MFDHLSYLLE NSGIGLGMQG STPLDVAAAS
     VIDNNELALA LQEQDLEKVV SYLAGCGLQS CPMLLAKGYP DIGWNPCGGE RYLDFLRFAV
     FVNGESVEEN ANVVVRLLIR KPECFGPALR GEGGSGLLAA IEEAIRISED PARDGPGVRR
     DRRREHFGEE PPEENRVHLG HAIMSFYAAL IDLLGRCAPE MHLIQAGKGE ALRIRAILRS
     LVPLDDLVGI ISLPLQIPTL GKDGALVQPK MSASFVPDHK ASMVLFLDRV YGIENQDFLL
     HVLDVGFLPD MRAAASLDTA TFSTTEMALA LNRYLCLAVL PLITKCAPLF AGTEHRAIMV
     DSMLHTVYRL SRGRSLTKAQ RDVIEDCLMA LCRYIRPSML QHLLRRLVFD VPILNEFAKM
     PLKLLTNHYE RCWKYYCLPT GWANFGVTSE EELHLTRKLF WGIFDSLAHK KYDAELYRMA
     MPCLCAIAGA LPPDYVDASY SSKAEKKATV DAEGNFDPRP VETLNVIIPE KLDSFINKFA
     EYTHEKWAFD KIQNNWSYGE NIDEELKTHP MLRPYKTFSE KDKEIYRWPI KESLKAMIAW
     EWTIEKAREG EEEKTEKKKT RKISQSAQTY DPREGYNPQP PDLSGVTLSR ELQAMAEQLA
     ENYHNTWGRK KKQELEAKGG GTHPLLVPYD TLTAKEKARD REKAQELLKF LQMNGYAVTR
     GLKDMELDTS SIEKRFAFGF LQQLLRWMDI SQEFIAHLEA VVSSGRVEKS PHEQEIKFFA
     KILLPLINQY FTNHCLYFLS TPAKVLGSGG HASNKEKEMI TSLFCKLAAL VRHRVSLFGT
     DAPAVVNCLH ILARSLDART VMKSGPEIVK AGLRSFFESA SEDIEKMVEN LRLGKVSQAR
     TQVKGVGQNL TYTTVALLPV LTTLFQHIAQ HQFGDDVILD DVQVSCYRTL CSIYSLGTTK
     NPYVEKLRPA LGECLARLAA AMPVAFLEPQ LNEYNACSVY TTKSPRERAS KLCAAGDSRA
     CGGPCTPVLG LPNSVEEMCP DIPVLERLMA DIGGLAESGA RYTEMPHVIE ITLPMLCSYL
     PRWWERGPEA PPPALPAGAP PPCTAVTSDH LNSLLGVGSR VTGQRPASSK SPATRCAPAV
     FAQPIVSRAR PELLHSHFIP TIGRLRKRAG KVVAEEEQLR LEAKAEAEEG ELLVRDEFSV
     LCRDLYALYP LLIRYVDNNR AHWLTEPNPS AEELFRMVGE IFIYWSKSHN FKREEQNFVV
     QNEINNMSFL TADNKSKMAK AGDVQSGGSD QERRKKKRRG DRYSVQTSLI VATLKKMLPI
     GLNMCAPTDQ ELITQAKNRY ALKDTDEEVR EYLQNNLHLQ GKVEGSPSLR WQMALYRGLP
     GREEDADDPE KIVRRVQEVS AVLYHLEQIE HPYKSKKAVW HKLLSKQRRR AVVACFRMTP
     LYNLPTHRAC NMFLESYKAA WILTEDHSFE DRMIDDLSKA GEQEEEEEEV EEKKPDPLHQ
     LVLHFSRTAL TEKSKLVEDY LYMAYADIMA KSCHLEEGGE NGEAQEEEVE VSFEEKEMEK
     QRLLYQQSRL HNRGAAEMVL QMISACKGET GAMVSSTLKL GISILNGGNA DVQQKMLDYL
     KDKKEVGFFQ SIQALMQTCS VLDLNAFERQ NKAEGLGMVN EDGTVINRQN GEKVMADDEF
     TQDLFRFLQL LCEGHNNDFQ NYLRTQTGNT TTINIIICTV DYLLRLQESI SDFYWYYSGK
     DVIEEQGKRN FSKAMSVAKQ VFNSLTEYIQ GPCTGNQQSL AHSRLWDAVV GFLHVFAHMM
     MKLAQDSSQI ELLKELLDLQ KDMVVMLLSL LEGNVVNGMI ARQMVDMLVE SSSNVEMILK
     FFDMFLKLKD IVGSEAFQDY VTDPRGLISK KDFYKAMDSQ KQFTGPEIQF LLSCSEADEN
     EMINCEEFAN RFQEPARDIG FNVAVLLTNL SEHVPHDPRL RNFLELAESI LEYFRPYLGR
     IEIMGASRRI ERIYFEISET NRTQWEMPQV KESKRQFIFD VVNEGGESEK MELFVSFCED
     TIFEMQIAAQ ISEPEGEPEA DDDDGAAEAG VEGAEEGAAG PEGAAGPAAA GVTARAAAAA
     ARALRGLSYR SLRRRVRRLR RLTAREAAAA VAALLWAAVA RAAGAGAGAA AGALRLLWGS
     LFGGGLVEGA KKVTVTELLA GMPDPTGDEV HGEQPAGPGG DADGEGAGEG ADGEAEGAGD
     EEAAAHEAGP GGPDGAVAVA EGGPFRPEGA GGLGDMGDTT PAEPPTPEGS PIIKRKLGVD
     GEEEELPPEP EPEPEPEPEK ADAENGEKEE VPEPPPEPPK KTAPPPPPPK KEEAGGAGLE
     FWGELEVQRV KFLNYLSRNF YTLRFLALFL AFAINFILLF YKVSDSPPGE DDMEGSAAGD
     LSGAGSGGGS GWGSGAGEEA EGDEDENMVY YFLEESTGYM EPALRCLSLL HTLVAFLCII
     GYNCLKVPLV IFKREKELAR KLEFDGLYIT EQPEDDDVKG QWDRLVLNTP SFPSNYWDKF
     VKRKVLDKHG DIYGRERIAE LLGMDLATLE ITAHNERKPE PPPGLLTWLM SIDVKYQIWK
     FGVIFTDNSF LYLGWYMVMS LLGHYNNFFF AAHLLDIAMG VKTLRTILSS VTHNGKQLVM
     TVGLLAVVVY LYTVVAFNFF RKFYNKSEDE DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD
     EIEDPAGDEY ELYRVVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMETKCF
     ICGIGSDYFD TTPHGFETHT LEEHNLANYM FFLMYLINKD ETEHTGQESY VWKMYQERCW
     DFFPAGDCFR KQYEDQLS
//
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