GenomeNet

Database: UniProt
Entry: F1PJL2_CANLF
LinkDB: F1PJL2_CANLF
Original site: F1PJL2_CANLF 
ID   F1PJL2_CANLF            Unreviewed;      4813 AA.
AC   F1PJL2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   30-AUG-2017, entry version 49.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSCAFP00000012007};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSCAFP00000012007};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000012007, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000012007, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000012007,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000012007}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000012007};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000012007}.
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DR   EMBL; AAEX03016025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03016026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03016027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9615.ENSCAFP00000012007; -.
DR   PaxDb; F1PJL2; -.
DR   Ensembl; ENSCAFT00000012974; ENSCAFP00000012007; ENSCAFG00000008056.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F1PJL2; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-CFA-2672351; Stimuli-sensing channels.
DR   Reactome; R-CFA-5578775; Ion homeostasis.
DR   Proteomes; UP000002254; Chromosome 30.
DR   Bgee; ENSCAFG00000008056; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 4.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4354   4374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4422   4441       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4553   4571       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4614   4635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4694   4717       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       44     99       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      106    151       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    213       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      219    277       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      287    344       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      529    740       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      956   1152       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1198   1410       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3861   3896       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4813 AA;  545950 MW;  F8E1CD12B2005121 CRC64;
     QYVPPDLCVC NFVLEQSLSV RALQEMLANT GENGGEGAAQ GGGHRTLLHG HAVLLRHSFS
     GMYLTCLTTS RSQTDKLAFD VGLREHATGE ACWWTIHPAS KQRSEGEKVR IGDDLILVSV
     SSERYLHLSV SNGNIQVDAS FMQTLWNVHP TCSGSSIEEG YLLGGHVVRL FHGHDECLTI
     PSTDQNDSQH RRIFYEAGGA GTRARSLWRV EPLRISWSGS NIRWGQAFRL RHLTTGHYLA
     LTEDQGLILQ DRAKSDTKST AFSFRASKEI KEKLDSSHKR DIEGMGVPEI KYGDSICFVQ
     HMASGLWVTY KAQDAKNPRL GPLKRKVILH QEGHMDDGLT LQRCQREESQ AARIIRNTTA
     LFSQFVSGNN RTAAPIALPI EEVLQTLQDL IAYFQPPEEE MQHEDKQNKL RSLKNRQNLF
     KEEGMLALVL NCIDRLNIYN SVAHFAGIAR EESGTAWKEI LNLLYKLLAA LIRGNRNNCA
     QFSNNLDWLI SKLDRLESSS GILEVLHCIL IESPEALNLI AEGHIKSIIS LLDKHGRNHK
     VLDVLCSLCL CNGVAVRANQ NLICDNLLPR RNLLLQTRLI NDVTSIRPNI FLGVAEGSAQ
     YKKWYFELII DQVDPFLTAE PTHLRVGWAS SSGYAPYPGG GEGWGGNGVG DDLYSYGFDG
     LHLWSGRIPR AVASINQHLL RSDDVVSCCL DLGVPSISFR INGQPVQGMF ENFNTDGLFF
     PVVSFSAGVK VRFLMGGRHG EFKFLPPSGY APCYEALLPK EKMRLEPVKE YKRDAEGVRD
     LLGTTQSLSQ ASFIPCPIDT SQVVLPPHLE KIRDRLAENI HELWGMNKIE LGWTFGKIRD
     DNKRQHPCLV EFSKLPETEK NYNLQMSTET LKTLLALGCH IAHINPAAEE DLKKVKLPKN
     YMMSNGYKPA PLDLSDVKLL PPQEILVDKL AENAHNVWAK DRIKQGWTYG IQQDLKNKRN
     PRLVPYALLD ERTKKSNRDS LREAVRTFIG YGYNIEPSDQ ELADPAVEKV SIDKIRFFRV
     ERSYAVRSGK WYFEFEVVTG GDMRVGWARP GCRPDIELGA DDQAFVFEGS RGQRWHQGSG
     YFGRTWQPGD VVGCMINLDD ASMIFTLNGE LLITNKGSEL AFADYEIENG FVPICSLGLS
     QIGRMNLGMD ASTFKFYTMC GLQEGFEPFA VNMNRDVAMW FSKRLPTFVN VPKDHPHIEV
     VRVDGTVDSP PCLKVTHRTF GAQSGGASMV YCRLSMPVEC HSSFSHGPCP DGDAVHKRKQ
     MQEILSPTTT QCYYAIRIFA GQDPSCVWVG WVTPDYHLHS EKFDLNKNCT VTVTLGDERG
     RVHESVKRSN CYMVWCGDIV ATSQRSSRSN VDLEIGCLVD LAMGMLSFSA NGRELGTCYQ
     VEPNTKVFPA VFLQPTSTSL FQFELGKLKN AMPLSAAIFK SEEKNPVPQC PPRLDVQTIQ
     PVLWSRMPSS FLKVETERVS ERHGWVVQCL EPLQMMALHI PEENRCVDVL ELCEQEDLMY
     FHYHTLRLYS AVCALGNSRV AYALCGHVDL SQLFYAIDNK YLPGLLRSGF YDLLISIHLA
     HAKERKLMMK NEYIIPITST TRKIRLYPDE SKRHGLPGVG LRTCLRPGFR FSTPCFVVTG
     EEHQKQSPEI PLEILKTKAL SMLTEAVQHS GAHIRDPVGG SVEFQFVPVL KLIGTLLVMG
     VFDDDDVRQI LLLIDSSVFG EHGAETEDGT EKEEVTQVEE KAVEAGEKAS KEAPVKGLLQ
     TRLPESVKLQ MCELLSYLCD CELQHRVEAI VAFGDIYVSK LQANQKFRYN ELMQALNMSA
     ALTARKTREF RSPPQEQINM LLNFQLGENC PCPEEIREEL YDFHEDLLIH CGVPLEEEEE
     EEEDTSWTGK LRALVYKIKG PPKPEKKQPI EEEERYPTTL KELISQTMIR WAQEDQIQDA
     ELVRMMFTLL QRQYDSIGEL LQALRKTYTI SQASVSDTIN LLAALGQIRC LLSVRMGKEE
     ELLMINGLGD IMNNKVFYQH PNLMRVLGMH ETVMEVMVNV LGAEKSQIAF PKMVASCCRF
     LCYFCRISRQ NQKAMFEHLS YLLENSSVGL ASPSMRGSTP LDVAASSVMD NNELALGLEE
     PDLEKVVTYL AGCGLQSCPM LLAKGYPDVG WNPIEGERYL SFLRFAVFVN SESVEENASV
     VVKLLIRRPE CFGPALRGEG GNGLLAAMQG AIKISENPAL DLPSQGYKRE VMEDSEDEEI
     VHMGNAIMSF YSALIDLLGR CAPEMHLIQT GKGEAIRIRS ILRSLVPTED LVGIISIPLK
     LPSLNKDGSI SEPDMAANFC PDHKAPMVLF LDRVYGIKDQ TFLLHLLEVG FLPDLRASAS
     LDTVSLSTTE AALALNRYLC SAVLPLLTRC APLFAGTEHY TSLIDSTLQT IYRLSKGRSL
     TKAQRDTIEE CLLAICNHLR PSMLQQLLRR LVFDVPQLNE YCKMPLKLLM NHYEQCWKYY
     CLPSGWGSYG LAVEEELHLT EKLFWGIFDS LSHKKYDPDL FRMALPCLSA IAGALPPDYL
     DTRISAMLEK QISVDADGNF DPKPINTTNF SLPEKWEYIV TKYAEHSHDK WACDKSQNGW
     KYGISLDENV KTHPLIRPFK TLTEKEKEIY RWPARESLKT MLAVGWSVER TKEGEALAQQ
     RENEKLRSVS QASQGNSYSP APLDLSNVVL SRELQGMVEV VAENYHNIWA KKKKLELESK
     GGGSHPLLVP YDTLTAKEKF RDREKAQDLF KFLQVNGILV SRGMKDMELD ASSMEKRFAY
     KFLKKILKYV DSAQEFIAHL EAIISSGKTE KSPHDQEIKF FAKVLLPLVD QYFTNHRLYF
     LSSPLKPLSS SGYASHKEKE MVARCSLFCK LAALVRHRIS LFGSDSTTMV SCLHILAQTL
     DTRTVMKSGS ELVKAGLRAF FENAAEDLEK TSENLKLGKF THSRTQIKGV SQNINYTTVA
     LLPILTSIFE HVAQHQFGVD LLLGDVQISC YHILCSLYSL GTGKNIYVER QRPALGECLA
     SLAAAIPVAF LEPTLNRYNP LSVFNTRTPR ERSILGMPDT VEEMCPDLPQ LEGLMKEISD
     LAESGARYTE MPHVIEVILP MLCNYLSYWW ERGPEHLPPS TGPWCTRVTS EHLSVILGNI
     LKIINNNLGI DEASWMKRIA ANAVYAQPII SKARPDLLKS HFIPTLEKLK KKAVKTVQEE
     EQLKADTKGD TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRSNWLKS PNADSDQLFR
     MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGDSKS KMSKSGGQDQ ERRKTKRRGD
     LYSIQTSLIV AALKKMLPIG LNMCTPGDQE LISLAKARYG ARDTDEEVKE HLRNNLHLQE
     KSDDPAVKWQ LNLYKDVLKS EEPFNPEKTV ERVQRISAAV FHLEQVEQPL RSKKAVWHKL
     LSKQRKRAVV ACFRMAPLYN LPRHRSINLF LHGYQRFWIE TEEYSFEEKL VQDLAKSPKE
     EEEEEEETEK QPDPLHQIIL HFSRNALTER SKLEDDPLYT SYSSMMAKSC QSGEDEEEEE
     DKEKTFEEKE MEKQKTLYQQ ARLHERGAAE MVLQMISASK GEMSPMVVET LKLGIAILNG
     GNAGVQQKML DYLKEKKDAG FFQSLSGLMQ SCSVLDLNAF ERQNKAEGLG MVTEEGTLIV
     RERGEKVLQN DEFTRDLFRF LQLLCEGHNS DFQNFLRTQM GNTTTVNVII STVDYLLRLQ
     ESISDFYWYY SGKDIIDESG QHNFSKALAV TKQIFNSLTE YIQGPCIGNQ QSLAHSRLWD
     AVVGFLHVFA NMQMKLSQDS SQIELLKELL DLLQDMVVML LSLLEGNVVN GTIGKQMVDT
     LVESSTNVEM ILKFFDMFLK LKDLTSSDTF KEYDPDGKGI ISKKEFQKAM EGQKQYTQSE
     IDFLLSCAEA DENDMFNYID FVDRFHEPAK DIGFNVAVLL TNLSEHMPND SRLKCLLDPA
     ESVLNYFEPY LGRIEIMGGA KKIERVYFEI SESSRTQWEK PQVKESKRQF IFDVVNEGGE
     QEKMELFVNF CEDTIFEMQL ASQISESDSA DRPEEEEEED EDSSYMLEIE GEEEDSKSLE
     SASAFAMACA SVKRNVANFL KKATLKNLRK QYRKVKKMTV KELVKVFFSF FWMLFLELFR
     LFFAILGGIF QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDA MDSERAEVTE
     PGITPELIHF VKAEKGDTDI MSDLFGFHPK KEGGLKHGPE VGLGDLSEII GKDEPPTLES
     TVQKKRKAQA AEMKAAHDAE GKVEPEKMDL EDGEKEDMAK EEEQAEAPWA EVTKKKKPRR
     GQKVEKPEAF MANFFKGLEI YQTKLLHYLA RNFYNLRFLA LFVAFAINFI LLFYKVTEEP
     LEEETEDIAN LWNSFNDEEE EEAMVFFVLQ ESTGYMAPTL RALAIIHTII SLVCVVGYYC
     LKVPLVVFKR EKEIARKLEF DGLYITEQPS EDDIKGQWDR LVINTPSFPN NYWDKFVKRK
     VINKYGDLYG AERIAELLGL DKNALDFSPV EENKAEAASL VSWLSSIDMK YHIWKLGVVF
     TDNSFLYLAW YTTMSVLGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL
     AVVVYLYTVV AFNFFRKFYN KSEDDDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP
     AGDPYEMYRI VFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG
     NDYFDTTPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA
     GDCFRKQYED QLG
//
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