GenomeNet

Database: UniProt
Entry: F1PUW3_CANLF
LinkDB: F1PUW3_CANLF
Original site: F1PUW3_CANLF 
ID   F1PUW3_CANLF            Unreviewed;       457 AA.
AC   F1PUW3;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   25-APR-2018, entry version 47.
DE   SubName: Full=Potassium voltage-gated channel subfamily Q member 1 {ECO:0000313|Ensembl:ENSCAFP00000015023};
GN   Name=KCNQ1 {ECO:0000313|Ensembl:ENSCAFP00000015023,
GN   ECO:0000313|VGNC:VGNC:51877};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000015023, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000015023, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000015023,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000015023}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000015023};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03011552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011558; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCAFT00000016239; ENSCAFP00000015023; ENSCAFG00000010231.
DR   VGNC; VGNC:51877; KCNQ1.
DR   eggNOG; KOG1419; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00550000074513; -.
DR   Reactome; R-CFA-1296072; Voltage gated Potassium channels.
DR   Reactome; R-CFA-5576890; Phase 3 - rapid repolarisation.
DR   Reactome; R-CFA-5576893; Phase 2 - plateau phase.
DR   Proteomes; UP000002254; Chromosome 18.
DR   Bgee; ENSCAFG00000010231; -.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR005827; K_chnl_volt-dep_KCQN1.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF109; PTHR11537:SF109; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01460; KCNQ1CHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00417267, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00417211,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00417245,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM    104    126       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    169    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    196       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      346    426       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
SQ   SEQUENCE   457 AA;  51733 MW;  595497D495E2476E CRC64;
     MEIVLVVFFG TEYVVRLWSA GCRSKYVGIW GRLRFARKPI SIIDLIVVLA SMVVLCVGSK
     GQVFATSAIR GIRFLQILRM LHVDRQGGTW RLLGSVVFIH RQELITTLYI GFLGLIFSSY
     FVYLAEKDAV NDSGQVEFGS YADALWWGVV TVTTIGYGDK VPQTWVGKTI ASCFSVFAIS
     FFALPAGILG SGFALKVQQK QRQKHFNRQI PAAASLIQTA WRCYAAENPD SSTWKIYVRK
     PARSHALLSP SPKPKKSVMV KRKKFKQDKD NGVSPGEKML TVPHITCEPV SEERRPDHFS
     VDNCDSSVKK SPMLLEVSTA HFMRTNSFAE DLDLEGETLL APITHVSQLR EHHRATIKVI
     RRMQYFVAKK KFQQARKPYD VRDVIEQYSQ GHLNLMVRIK ELQRRLDQSI GKPSLFISVS
     EKSKDRGSNT IGARLNRVED KICKGLSTFC CKDYFPH
//
DBGET integrated database retrieval system