GenomeNet

Database: UniProt
Entry: F1Q208_CANLF
LinkDB: F1Q208_CANLF
Original site: F1Q208_CANLF 
ID   F1Q208_CANLF            Unreviewed;      1058 AA.
AC   F1Q208;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   25-OCT-2017, entry version 46.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 2 {ECO:0000313|Ensembl:ENSCAFP00000035367};
GN   Name=KCNH2 {ECO:0000313|Ensembl:ENSCAFP00000035367};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000035367, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000035367, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000035367,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000035367}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000035367};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000035367}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAEX03010270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03010271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F1Q208; -.
DR   Ensembl; ENSCAFT00000039504; ENSCAFP00000035367; ENSCAFG00000025442.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140833; -.
DR   Reactome; R-CFA-1296072; Voltage gated Potassium channels.
DR   Reactome; R-CFA-5576890; Phase 3 - rapid repolarisation.
DR   Proteomes; UP000002254; Chromosome 16.
DR   Bgee; ENSCAFG00000025442; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01470; ERGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    309    330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    446    470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    538    562       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      641    741       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      934    961       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1058 AA;  115225 MW;  65B20BFA4C633A1C CRC64;
     GSCFLCLVDV VPVKNEDGAV IMFILNFEVV MEKDMVGSPT HDTNHRGPPT SWLAPGRAKT
     FRLKLPALLA LTTRESSARP GGVGSAGAPG AVVVDVDLSP AVPSRESLAL DEVTAMDNHV
     AGLGPMEEQR ALVGSSSPPA GAPEPLPSPR AHSLNPDASG SSCSLARTRS RESCASVRRA
     SSADDIEAMR AGLPPPPRHA STGAMHPLRG GLLNSTSDSD LVRYRTISKI PQITLNFVDL
     KGDPFLASPT SDREIIAPKI KERTHNVTEK VTQVLSLGAD VLPEYKLQAP RIHRWTILHY
     SPFKAVWDWL ILLLVIYTAV FTPYSAAFLL KETEEGPPAP DCGYACQPLA VVDFIVDIMF
     IVDILINFRT TYVNANEEVV SHPGRIAVHY FKGWFLIDMV AAIPFDLLIF GSGSEEAKLI
     GLLKTARLLR LVRVARKLDR YSEYGAAVLF LLMCTFALIA HWLACIWYAI GNMEQPHMDS
     RIGWLHNLGD QIGKPYNSSG LGGPSIKDKY VTALYFTFSS LTSVGFGNVS PNTNSEKIFS
     ICVMLIGSLM YASIFGNVSA IIQRLYSGTA RYHTQMLRVR EFIRFHQIPN PLRQRLEEYF
     QHAWSYTNGI DMNAVLKGFP ECLQADICLH LNRSLLQHCK PFRGATKGCL RALAMKFKTT
     HAPPGDTLVH AGDLLTALYF ISRGSIEILR GDVVVAILGK NDIFGEPLNL YARPGKSNGD
     VRALTYCDLH KIHRDDLLEV LDMYPEFSDH FWSSLEITFN LRDTNMIPGS PGSAELEGGF
     NRQRKRKLSF RRRTDRDPEQ PGEVSALGPG RAGAGPSGRG RPGGPWGESP SSGPSSPESS
     EDEGPGRSSS PLRLVPFSSP RPPGEPPGGE PLTEDGEKSS DTCNPLSGAF SGVSNIFSFW
     GDSRGHQYQE LPRCPAPTPS LLNIPLSSPC RRPRGDVEGR LDALQRQLNR LETRLSADMA
     TVLQLLQRQM TLIPPAYSAV TTPGPGPTST SSLLPVSPIP TLTLDSLSQV SQFMAFEELP
     PGAPELPQDG PPRRLSLPGQ LGALTSQPLH RHGSDPGS
//
DBGET integrated database retrieval system