GenomeNet

Database: UniProt
Entry: F1QA22_DANRE
LinkDB: F1QA22_DANRE
Original site: F1QA22_DANRE 
ID   F1QA22_DANRE            Unreviewed;       514 AA.
AC   F1QA22;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   28-MAR-2018, entry version 53.
DE   SubName: Full=Lipase, hepatic a {ECO:0000313|Ensembl:ENSDARP00000069990};
GN   Name=lipca {ECO:0000313|Ensembl:ENSDARP00000069990,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-1361};
GN   Synonyms=lipc {ECO:0000313|ZFIN:ZDB-GENE-040426-1361};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000069990, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000069990}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000069990};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000069990, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000069990,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; BX957301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000069990; -.
DR   PaxDb; F1QA22; -.
DR   Ensembl; ENSDART00000075508; ENSDARP00000069990; ENSDARG00000053476.
DR   ZFIN; ZDB-GENE-040426-1361; lipca.
DR   eggNOG; ENOG410IIHP; Eukaryota.
DR   eggNOG; ENOG4110MCZ; LUCA.
DR   GeneTree; ENSGT00760000119069; -.
DR   OMA; CHFLELY; -.
DR   OrthoDB; EOG091G052B; -.
DR   TreeFam; TF324997; -.
DR   Reactome; R-DRE-8963889; Assembly of active LPL and LIPC lipase complexes.
DR   Reactome; R-DRE-8964026; Chylomicron clearance.
DR   Proteomes; UP000000437; Chromosome 7.
DR   Bgee; ENSDARG00000053476; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR002333; Lipase_hep.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   PANTHER; PTHR11610:SF2; PTHR11610:SF2; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00824; HEPLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    514       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5009954121.
FT   DOMAIN      351    484       PLAT. {ECO:0000259|PROSITE:PS50095}.
FT   ACT_SITE    164    164       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    191    191       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    278    278       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
SQ   SEQUENCE   514 AA;  57933 MW;  79333B3735D7848C CRC64;
     MKTLIKIVSC FLMISQLTDG ATFQGNRADT EPEAKMKMRY EPKSVFRVYT DGEYIEDTCA
     LELFQPHTLD ACGFNSSLPL AIIIHGWSVD GMMEKWISRL ASALKSSEGN INVLIADWLT
     LAHQHYPIAA QNTRIVGQDI AHLLSWLEDF KQFPLGKVHL IGYSLGAHIS GFAGSNLAMS
     GRTLGRITGL DPAGPMFEGM SHTDRLSPED AKFVDAIHTF TLQRMGLSVG IKQPVAHFDF
     YPNGGSFQPG CQLHMQNIYA HLAQHGIMGF EQTVKCAHER AVHLFIDSLL NKDKQIMAYK
     CSDNTAFDKG NCLDCRKNRC NTLGYDIKKV RTGKSKRLFL KTRSHMPYKL FHYQFRIQFI
     NQIDKIDPTL TVSLTGTLGE SENLPITLVE EISGNKTFTL LITLDTDIGD LMIMRFTWEG
     NPVWANMWNT VKTIIPWGKK SKGPQLTFGK ITVKSGESQR KTTFCPQTDE GLSIEMLQEK
     VFVRCEKQKP GGIKHTHLRH FHIQSDLSFW MGDS
//
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