GenomeNet

Database: UniProt
Entry: F1QCK4_DANRE
LinkDB: F1QCK4_DANRE
Original site: F1QCK4_DANRE 
ID   F1QCK4_DANRE            Unreviewed;      5062 AA.
AC   F1QCK4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   22-NOV-2017, entry version 52.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSDARP00000120294};
GN   Name=ryr1a {ECO:0000313|Ensembl:ENSDARP00000120294,
GN   ECO:0000313|ZFIN:ZDB-GENE-020108-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000120294, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000120294}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000120294};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000120294, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000120294,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000120294}.
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DR   EMBL; BX088525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000012040; -.
DR   PaxDb; F1QCK4; -.
DR   PRIDE; F1QCK4; -.
DR   Ensembl; ENSDART00000137089; ENSDARP00000120294; ENSDARG00000011422.
DR   ZFIN; ZDB-GENE-020108-2; ryr1a.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Proteomes; UP000000437; Chromosome 10.
DR   Bgee; ENSDARG00000011422; -.
DR   ExpressionAtlas; F1QCK4; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F1QCK4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4352   4375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4582   4602       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4666   4687       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4802   4820       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4864   4884       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4943   4966       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    159       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      166    211       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      219    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    343       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      606    805       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1021   1217       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1351   1565       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1897   1935       {ECO:0000256|SAM:Coils}.
FT   COILED     3696   3723       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5062 AA;  573664 MW;  17C98CB70B691052 CRC64;
     MAEGAEGEEE IQFLRTDDQV VLQCTATILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLANTTELNE AVDLDKWSSQ GGGHRTLLYG HAILLRHTHS
     GMYLSCLTTS RSLTDKLAFD VGLQEDSTGE ACWWTIHPAS KQRSEGEKVR VGDDIILVSV
     SSERYLHLSY ASGDLMVDAS FMQTLWNMNP VCSGCELAEG FLTGGHVLRL FHGHMDECLT
     IPGAEQGDDQ RRNAHYEGGA VCSHARSLWR LEPLRIGWSG SHMKWGQSFR VRHITTGRYL
     CLDEEKGLLI VDPEKANTKQ SAFCFRASKE KTEVAQKRDV EGMGIPEIKY GESMCFVQHV
     ATSLWLTYAS VDAKSARLGP LKRKAILHQE GHMDDALTVA RSQTAESQAA RMIYNTAGLF
     TQFIKGLDSL SGKSKSPGPS PSLPLDAIVL SLQDLIFYFR PPEEELEHEE KQTKLRSLRN
     RQNLFQEEGM ITLVLDCVDR LNVYNTSAHF SEFAGEDAAE SWKEIVNLFY ELLASLIRGN
     RANCALFCDN LDWLVSKLDR LEASSGILEV LYCILIESPE VLNIIQENHI KSIIALLDKH
     GRNHKVLDVL CSLCVCNGVA VRSNQNLITE NLLPGRDLLL QTNIINYVTS MRPNIFLGTC
     EGSTQYKKWY YELIVDHVES FLTAHPFHLR VGWALTEGYS PYPGGGEGWG GNGVGDDLHS
     YGFDGLNLWT GRVPRQVTSP SQHILSAEDV VSCCLDLSVP SISFRINGHP VQGMFENFNL
     DGLFFPVVSF SAGIKVRFLL GGRQGDFKFL PPPGYAPCYE AVLPKDRLRI EPIKEYKHDN
     DGVRNLLGPT QSLSHTAFTP CPVDTVQIVL PPHLERIREK LAENSHELWA VTRIEQGWTY
     GLFRDDNKKL HPCLVDFQSL PDPEKSYNLA MSGETLKTLL ALGCHVGMGD EKAEENLKKI
     KLPKTYMQCN GYKPAPLDLN HVKLTPNQNT LVERLAENGH NVWARDRVRQ GWTYSIIQDI
     VNKRNPRLVP YILLDEKTKK TNRDTVCAAV RTLIGYGYNI EPPDQESSGH GGGNGRSDKI
     RVFRAEKSYA VTQGKWYFEF EAVTVGEMRV GWARPSVHAD RELGSDDLAY VFNGFKSQRW
     HIGNEPFGRQ WQSGDVVGCM IDLTEQNIMF TLNGEMLISD SGSEMAFKDI EIGEGFIPVC
     SLGMSQVGRI NLGQNVSSLR YFTICGLQEG FEPFAINMKR DITMWFSKSL PQFVPVPTDH
     PHIEVSRVDG TVESAPCLKL THRTFGSQNA NTDLLFFRLS MPIEFHETFK VPVGASPLTR
     TLTIPEDETL EVDPESEFEL LKKSATRKEQ DEKEKEPSVP KELPGSKESE NEKDTTTEKS
     KKRGFFSKAK KAAFIAPPPV VPTMPRLMED VVPDDRDDVE IISNTTTYYY SVRVFAGQEP
     SGVWVGWVTP DYHLYDLHFD LCKVRNVTVT VGDDKGNIHD SVKRSNCYMV WGGEFSSSQQ
     TRISQEDFVI GCLVDLDTGL MTFTANGKEI NTFYQVEPNT KLFPAVFCLP SSQNMLQVEL
     GKLKNIMPIS AAMFRSDCKN PVPQCPPRLD LQMLTPVIWS RMPNHFLSPE TGRVSERQGW
     KVQCMEPLVM MALHIPEENR CIDILELSER TDLMKFHYHT LKLYGSVCAL GNNRVAHALC
     SHVDESQLFY AIENTYLPGP IRSGYYDLLI SMHLESAKRN RLMTNKEFIV PMTDETRSIT
     LYSDAEKAHA LPGVGLTTCL RPKLHFAPTG FVGTNADLYT LSPMLPLQML KDHALSMLTE
     AVQDGGQAIR DPVGGSVEYH FVPILKLIST LLIMGVFDDD DVKHILKLIE PSVFSSNSET
     PAEETGDPEQ QLVCKEEGAE VKEQEEPADG GNDGELLDEG MGEEEELEEE EEEEDEEYEE
     EVKKEEDEHA AEKTDREKTT DGETEKETGA AEAEVREEED VGEGLLHMKL PESVKLQMCT
     LLQYFCDCEL RHRVEAIIAF SDKFVNQVQT NQRQRYNELM QAFTMSAAET ARKTREFRSP
     PQEQVNMLMN FKNCPEEEDC PVPEDVRNGL LTFHHDLLAH CGVHIEEEEQ EEEVDTSLSG
     RLRRLVEKVK SLRKKPEAEP EPEEDKKPST LQELISHTMI YWAQESFIQN PELVRLMFSL
     LHRQYDALGE LIRALPKAYI INAVSIQDTM ELLECLGQIR SLLIVQMGPE EERLMIQSIG
     NIMSNRVFYQ HPNLMRALGM HETVMEVMVN VLGGGDSKEI RFPRMVTNCC RFLCYFCRIS
     RQNQRSMFDH LGYLLQNSGI GLGMRGSTPL DVAAASCIDN NELALALQEQ DLEMVVKYLA
     GCGLQSCPML LSKGYPDIGW NPVGGEKYLD FLRFAVFVNG ESVEENANVV VRLLIRRPEC
     FGPALRGEGG NGLLAAIEEA IKISEDPARD GPTVKKDRRF PMFGGEEQHE ENRVHLGNAI
     MSFYSALIDL LGRCAPEMHL IQAGKGEALR IRAILRSLVP IEDLVGVISL SVQIPAFGKD
     NSIIEPKMSA SFVPDHKAPM VLFLDRVYGI DNQDFLLHVL EVGFLPDMRA AASLDTAAFS
     TTEMALALNR YLCSAVLPLI TKCAPLFAGT DHRAIMIDSM LHTIYRLSRG RSLTKAQRDV
     IEECLMSLCR YLRPSMLQHL LRRLVFDVPI LNEYAKMPLK LLTNHYERCW KYYCLPNGWA
     NFGVSSEEEL HLTRKLFWGI FESLAHKKFD AELFKIAMPC ICAIAGAIPP DYVDASYSSK
     TEKKASVDAE GNFDPKPVDT TNTIIPEKLD GFINRYAEYT HDRWAFEKIQ NNWTFGEVMD
     ENAKTHPMLR PYKTFSEKDK EIYRWPIKES IKAMIAWEWT LDKARDGEDE KVEKKTARKI
     SQTAQATYDP SHGYSPQPID ISGMTLSREL QSMAEQLAEN YHNTWGRKKK MELQAKGGGT
     HPLLVPYDTL TAKEKARDRE KAYELLKFLQ LNGYAVTRGL KDMESDISSI EKRFAYGFLQ
     KLLKWMDIAQ EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI LLPLINQYFK NHCLYFLSTP
     AKILGSGGHA SNKEKEMIAS IFCKMSALVR HRVFLFGTDA PAIVNCLHIL ARSLDARTVM
     KSGPEIVKAG LRLFFESAAD DIEKMVENLK LGKVSKGNQP VKGVSQNINY TTTALLPVLT
     SLFDHIAQHQ FGDDVILDDL QMSCYRIMCS IYSLGTVKTP HAERHRPALG ECLAHLAAAM
     PVAYLEPHLN EYNAFSVYTT KTPRERAILG LPNQVQELCL DIPELDVLLK EIGDLAESGA
     RYTEMPHVIE VTLPMLCNYL PRWWERGLEN FPDLEGKLCT DVTSESLNQL LGSIMKIVVN
     NLGIDEASWM KRLAVFSQPI VSRAKPEMLK SHFIPTMEKL KKRTSKVVAE EEHLRLEGKS
     EGDEEEGTIR DEFAVLCRDL YALYPLLIRY VDNNRARWLT FRDPDAEELF RMVGEVFIFW
     SKSHNFKREE QNFVVMNEIN NMSFLTADSK SKMSKAGGSD VERTKKKRRG DRYSVQTSLI
     VAALKKMLPI GLNMCSPADQ ELINLAKTRY SLKDTDEEVR EFLQNNLHLQ GKVDNPSMRW
     QMALYKEMAG KAEDADAPEN VVKRVQEVSA VLYHIEVTEH PFKSKKMVWH KLLSKQRRRA
     VVACFRMTPL YNLPRHRASN MFLDGYKRNW IRNEGYSFED RMIDDLSKAL EEEEEEEEEK
     ETKPDPLHQL ILHFSRTALT EKSKLDIDHL YMAYADIMAK SCHMDEEDEG GEEENEGGEE
     EMSFEVRQTE MEKEMEKQRL LYQQSRLHNR GAAEMVLQMI SACKGETGCM VSSTLKLGIS
     ILNGGNCEVQ QKMLDYLKDK KDVGFFLSVQ ALMQTCSVLD LNAFERQNKA EGLGMVSEEG
     TSEKVMADDE FTCDLFRFLQ LLCEGHNNDF QNYLRTQTGS TTTINVIICT VDYLLRLQES
     ISDFYWYYSG KDIIDEPGKR NFSKAMTVAK QVFNSLTEYI QGPCTGNQQS LAHSRLWDAV
     VGFLHVFAHM MMKLAQDSSQ IGLLKELLDL QKDMVVMLLS LLEGNVVNGT IARQMVDMLV
     ESSSNVEMIL KFFDMFLKLK DIVASDAFRD YVTDPRGLIS KKDFQKSMDS QKQYTPSEIQ
     FLLSCSEADE NEMINYEEFA SRFQEPAKDI GFNIAVLLTN LSEHVPHDTR LQNFLEQAES
     VLNYFRPFLG RIEIMGASRK IERIYFEISE VNRKQWEMPQ VKESKRQFIF DVVNEGGESE
     KMELFVNFCE DTIFEMNIAS QISEQDEEEK EEDDIEEAEG GDAGDEEGGG EEGQPESSSA
     FADFIQSIMN FLGMFTFRNI RRKYRRLRKM TIKEIVVGLA TFMWTILLGI LHFIYSVCKG
     FFLLIWHTLF GGGLVEGAKN ITVTELLASM PDPTQDEVHG DLPGEPRGGE EQETGGIMDS
     MDAGGGEEED EDIQEKDGGK IPGIDTPGGL GDMGDTTPVE PPTPEGTPLL KRKAQPDEAG
     AEQPPAIEEP PPEPEKADIE NGEKAEKEVE VKPEPIPEEP KPQRATKAKK EKKSVKGAGF
     ELWNELDVQR NKFMNCLSRN FYNIRFLALF LAFALNFILL FYKVSDTPPS SDEFEGSGIF
     EGSGLFEGSA EDFEGSGGED GGDDEDEEGP VYYFLEESTG YMQPTLSFLA ILHTVIAFIS
     IIGYNCLKIP LVIFKREKEL ARKLEFDGLY ITEQPADDDI KGQWDRLVLN TPSFPTNYWD
     KFVKRKVLDK YGDIYGRERI AELLGMDLAS LDVSKQQTDK KPEEPDNSML AWFTSIDIKY
     QIWKFGVVFT DNTFLYLVWY TVMSLLGHYN NFFFACHLLD IAMGVKTLRT ILSSVTHNGK
     QLMMTVGLLA VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG
     GIGDEIEDPA GDEYELYRVV FDITFFFFVI VILLAIIQGL IIDAFGELRD QQEQVKEDME
     TKCFICGIGS DYFDTTPHGF ETHTLEEHNL ANYMFFLMYL INKDETEHTG QESYVWKMYQ
     ERCWDFFPAG DCFRKQYEDQ LG
//
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