ID F1QFF3_DANRE Unreviewed; 1883 AA.
AC F1QFF3; A0A8M3ARJ8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Myotubularin-related protein 5 isoform X6 {ECO:0000313|RefSeq:XP_009298448.1};
DE SubName: Full=SET-binding factor 1 {ECO:0000313|Ensembl:ENSDARP00000086032};
GN Name=sbf1 {ECO:0000313|Ensembl:ENSDARP00000086032,
GN ECO:0000313|RefSeq:XP_009298448.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040718-139};
GN Synonyms=wu:fj45d12 {ECO:0000313|RefSeq:XP_009298448.1}, zgc:92634
GN {ECO:0000313|RefSeq:XP_009298448.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000086032};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000086032}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000086032};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000086032, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000086032,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_009298448.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009298448.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; BX248111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009298448.1; XM_009300173.3.
DR Ensembl; ENSDART00000091599; ENSDARP00000086032; ENSDARG00000062968.
DR Ensembl; ENSDART00000091599.6; ENSDARP00000086032.5; ENSDARG00000062968.9.
DR GeneID; 568277; -.
DR AGR; ZFIN:ZDB-GENE-040718-139; -.
DR CTD; 6305; -.
DR ZFIN; ZDB-GENE-040718-139; sbf1.
DR eggNOG; KOG1090; Eukaryota.
DR eggNOG; KOG2080; Eukaryota.
DR OrthoDB; 3195274at2759; -.
DR Proteomes; UP000000437; Chromosome 4.
DR Bgee; ENSDARG00000062968; Expressed in retina and 23 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR CDD; cd13340; PH-GRAM_MTMR5; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR CDD; cd14588; PTP-MTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 6..428
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1107..1611
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1777..1881
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1057..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1883 AA; 212614 MW; 0B9700E8AED59658 CRC64;
MARLADYFVV VGYDLDKRGG SEGQGRIHQR FPEKDWEDNP FPQGLELFCQ PSGWQLAPER
KPSSFFVAVL TDINSERHYC ACFTFWESVE NPQLQKGEPS EADEDDSPDV LQPAQLYAPR
SLVLVSRLDH TEVFRNCLSL IYTVHVDGLT VPMETVIGNL LTCIIPIAGG SQRTITLGAG
DRQVIQTPIN DSLPVSGCSV AQLFRQLGIV NVLCLFCAAL TEHKILFLSS SYQRLTDACR
ALLAIMFPLK YSFTYVPILP GKLLEVLSSP TPFIIGVNSH FRSETQELLD VIIADLDGGT
VTIPECVHIS VLPEPLLHHT QTAISMVLDP ELEVADHAFP PPSIQPSALK IQDKEIRAVF
LWLFSQLFQG YRWCLHIIRI HPEPVIRFHK AAFLGQRALS EDDFLMKVLD GMAFAGFVSE
RGPPYRATDL FDDLIANQVE RIRKETGDPH KVMKHIKELA EQLFKNENPY PAVTMHRVQR
TAESAHPRLP QTSFPLLDEV AVQLFIDHAT AKLKTAPPVV KAELKSMVPT GPPLVDFVDR
NGNVLANSAR RLEVVRNCIT YIFDNKMLEA KKLMPAVLRA LKGRAARVCL TQELNLHVLQ
NRAVLDDQQF DYIVRMMNCT LQDCSHMDEH GIAAALLPLV TAFCRKLGGG ITQFAYSCVQ
EHMVWTNMQF WEAMFYSDVQ KHIRTLYLEN GEEGDASSPE VEGLGVSQNQ LSALELASEQ
SRLWPTLSKE QQQERVQKEE STVFSQAIHY ANRMSYLLLP LDTSKNRLLR NTGLGDVESV
SNSYVTNSIA GSMAESYDTE SGFEDAESSD VANSVVRFIN RFVDKVCNES GVTNEHLKAL
HTMIPDIVQM HIETLDAVHR ESKRLPPIQK PKLLRPTLLP GEEFVMDGMR VHLITDGREE
ATGSMGGPPL LPAEGAIFLT SYRLIFKGTP TDPLVGEQVV TRSFPVASLT KEKRISVSLP
MDQFIQEGLQ LRSCTFQLMK IAFDEEVASD LAEVFRKHMH KLRYPQHVQG TFAFTVGQSA
KLVVEHKTKD KNQSLKTLSR NLVKTAKRTI GRQYVTRKKY SPPTWENRSS MQSEMDEDEI
SVSEEPEPSS LTLSSTIRSS DRQTMSNVVE RACCRDYQRL GLGTLSNSLT RSKNEPFRIS
TVNRMYTVCR SYPGLLIVPQ SIPDSTIQRI CRCYRQNRFP VVCWRNSRTK AVLLRSAGLH
AKGVVGFFKS PNAPTAGPSQ ADSTSLEQEK YLQAIISSMP SYSETSGRNT LSGFTSSHMS
TSDSSDKLRQ PKIGALMKQV MGAKEDVPGT FSRGGKWGSI RGSGRLSTYN PDVGNRLAGK
ESPQANGGPS ETYFLRQQRA YLFIIGDKSQ LKGGKQDSFQ QWEVVPIEVF DVRQVKNSFK
KLMKACVPSS LSFDANMTFH RCLEESEWMN LLHRVLQVSV LVVELLDNGS SVMVSLEDGW
DVTTQVVSLV QLLSDPYYRT IDGFRLLVEK EWLSFGHRFS HRGAQTLASQ SSGFTPVFLQ
FLDCVHQIHL QFPMEFEFSQ YYLKFLAYHY VSNRFRTFLL DSDYERIELG VLYEEKGERK
STQVCKSVWD YIDRLNKKTP IFYNYMFSPE EEEVLKPYSF VSNLKVWDFY TEETLSEGPS
FDWELVQGRQ EKPQEEAGDK QETTAPKSKR RIVWPCYDNL SKVVPDAITK LLQDVQNLET
ELGQPTEKWK DTWDKIKTTQ RVESRLESRH SFSSSLLMSS NLSHQRRSQG VYLQESGVGS
SINLALDCEV SATSTPAAGR PSTSTLYSQF QSTESENRSF EGILYKKGAL LKPWKPRWFV
LDKTKHQLRY YETRQDKECK GMIELADVES VIPGTPAMGA PKNIDDKAFF DLKTTKRVYN
FCAQDSSNAQ SWMDSIQGCL SDA
//
