ID F1QM86_DANRE Unreviewed; 212 AA.
AC F1QM86; A0A8M1PFU2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Chromobox homolog 1a (HP1 beta homolog Drosophila) {ECO:0000313|Ensembl:ENSDARP00000118656};
DE SubName: Full=Chromobox protein homolog 1 {ECO:0000313|RefSeq:NP_956040.2};
GN Name=cbx1a {ECO:0000313|Ensembl:ENSDARP00000118656,
GN ECO:0000313|RefSeq:NP_956040.2,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-4945};
GN Synonyms=cbx1 {ECO:0000313|RefSeq:NP_956040.2}, wu:fe14b09
GN {ECO:0000313|RefSeq:NP_956040.2}, zgc:55739
GN {ECO:0000313|RefSeq:NP_956040.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000118656};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000118656}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118656};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:NP_956040.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_956040.2};
RX PubMed=24240475;
RA Huang H.T., Kathrein K.L., Barton A., Gitlin Z., Huang Y.H., Ward T.P.,
RA Hofmann O., Dibiase A., Song A., Tyekucheva S., Hide W., Zhou Y., Zon L.I.;
RT "A network of epigenetic regulators guides developmental haematopoiesis in
RT vivo.";
RL Nat. Cell Biol. 15:1516-1525(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000118656, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000118656};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_956040.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_956040.2};
RX PubMed=25059688;
RA Baumgart M., Groth M., Priebe S., Savino A., Testa G., Dix A., Ripa R.,
RA Spallotta F., Gaetano C., Ori M., Terzibasi Tozzini E., Guthke R.,
RA Platzer M., Cellerino A.;
RT "RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved
RT pathways and novel genes associated with neurogenesis.";
RL Aging Cell 13:965-974(2014).
RN [5] {ECO:0000313|RefSeq:NP_956040.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_956040.2};
RX PubMed=24467753;
RA Rakshambikai R., Srinivasan N., Gadkari R.A.;
RT "Repertoire of protein kinases encoded in the genome of zebrafish shows
RT remarkably large population of PIM kinases.";
RL J. Bioinform. Comput. Biol. 12:1350014-1350014(2014).
RN [6] {ECO:0000313|RefSeq:NP_956040.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_956040.2};
RX PubMed=25485542;
RA Solin S.L., Wang Y., Mauldin J., Schultz L.E., Lincow D.E., Brodskiy P.A.,
RA Jones C.A., Syrkin-Nikolau J., Linn J.M., Essner J.J., Hostetter J.M.,
RA Whitley E.M., Cameron J.D., Chou H.H., Severin A.J., Sakaguchi D.S.,
RA McGrail M.;
RT "Molecular and cellular characterization of a zebrafish optic pathway tumor
RT line implicates glia-derived progenitors in tumorigenesis.";
RL PLoS ONE 9:e114888-e114888(2014).
RN [7] {ECO:0000313|RefSeq:NP_956040.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_956040.2};
RX PubMed=25985063;
RA Sheng Y., Zhao W., Song Y., Li Z., Luo M., Lei Q., Cheng H., Zhou R.;
RT "Proteomic analysis of three gonad types of swamp eel reveals genes
RT differentially expressed during sex reversal.";
RL Sci. Rep. 5:10176-10176(2015).
RN [8] {ECO:0000313|RefSeq:NP_956040.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_956040.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL953901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR450718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_956040.2; NM_199746.2.
DR STRING; 7955.ENSDARP00000118656; -.
DR PaxDb; 7955-ENSDARP00000118656; -.
DR Ensembl; ENSDART00000143088.2; ENSDARP00000118656.1; ENSDARG00000004189.10.
DR Ensembl; ENSDART00000191483.1; ENSDARP00000146902.1; ENSDARG00000110945.1.
DR GeneID; 326746; -.
DR KEGG; dre:326746; -.
DR AGR; ZFIN:ZDB-GENE-030131-4945; -.
DR CTD; 326746; -.
DR ZFIN; ZDB-GENE-030131-4945; cbx1a.
DR eggNOG; KOG1911; Eukaryota.
DR HOGENOM; CLU_045874_1_2_1; -.
DR OMA; YNTWEKE; -.
DR OrthoDB; 75895at2759; -.
DR TreeFam; TF350503; -.
DR Proteomes; UP000000437; Alternate scaffold 3.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000004189; Expressed in gastrula and 29 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005721; C:pericentric heterochromatin; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd18654; CSD_HP1beta_Cbx1; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR017984; Chromo_dom_subgr.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR008251; Chromo_shadow_dom.
DR InterPro; IPR023779; Chromodomain_CS.
DR PANTHER; PTHR22812:SF160; CHROMOBOX HOMOLOG 1A (HP1 BETA HOMOLOG DROSOPHILA)-RELATED; 1.
DR PANTHER; PTHR22812; CHROMOBOX PROTEIN; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF01393; Chromo_shadow; 1.
DR PRINTS; PR00504; CHROMODOMAIN.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00300; ChSh; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 2.
PE 1: Evidence at protein level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1QM86};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 50..108
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 144..202
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 212 AA; 24252 MW; F5BE5BB2522DDEB1 CRC64;
MSMSQPTETV SDAPSVTEEV SPDSKLAATA GKKQTKKKVE DVVEEEEEEY VVEKVLDRRV
VKGRVEYLLK WKGFSEEDNT WEPEDNLDCP DLIAEYMTKH KINDDKKESS AKRKESDTDG
GGEDSRPKKR KDEQDKPRGF ARGLDPERII GATDSSGELM FLMKWKNSDE ADLVPAKEAN
VKCPQVVISF YEERLTWHSY PSEEEEKKDD KN
//
