ID F1QPL8_DANRE Unreviewed; 376 AA.
AC F1QPL8; A0A8M1P8D8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Substance-K receptor {ECO:0000256|ARBA:ARBA00020168};
DE AltName: Full=NK-2 receptor {ECO:0000256|ARBA:ARBA00031796};
DE AltName: Full=Neurokinin A receptor {ECO:0000256|ARBA:ARBA00032219};
DE AltName: Full=Tachykinin receptor 2 {ECO:0000256|ARBA:ARBA00031716};
GN Name=tacr2 {ECO:0000313|Ensembl:ENSDARP00000117211,
GN ECO:0000313|RefSeq:NP_001314788.1,
GN ECO:0000313|ZFIN:ZDB-GENE-090312-188};
GN Synonyms=si:ch211-1n9.11 {ECO:0000313|RefSeq:NP_001314788.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000117211};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000117211}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000117211};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:NP_001314788.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314788.1};
RX PubMed=22580006;
RA Zhou W., Li S., Liu Y., Qi X., Chen H., Cheng C.H., Liu X., Zhang Y.,
RA Lin H.;
RT "The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates
RT and molecular identification of the TAC3/TACR3 system in zebrafish (Danio
RT rerio).";
RL Mol. Cell. Endocrinol. 361:202-212(2012).
RN [3] {ECO:0000313|RefSeq:NP_001314788.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314788.1};
RX PubMed=22689988; DOI=10.1073/pnas.1119165109;
RA Biran J., Palevitch O., Ben-Dor S., Levavi-Sivan B.;
RT "Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in
RT controlling fish reproduction.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:10269-10274(2012).
RN [4] {ECO:0000313|RefSeq:NP_001314788.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314788.1};
RX PubMed=23256992;
RA Lopez-Bellido R., Barreto-Valer K., Rodriguez R.E.;
RT "Expression of tachykinin receptors (tacr1a and tacr1b) in zebrafish:
RT influence of cocaine and opioid receptors.";
RL J. Mol. Endocrinol. 50:115-129(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000117211, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000117211};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001314788.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314788.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; BX530068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001314788.1; NM_001327859.1.
DR STRING; 7955.ENSDARP00000117211; -.
DR PaxDb; 7955-ENSDARP00000117211; -.
DR Ensembl; ENSDART00000142129.3; ENSDARP00000117211.2; ENSDARG00000074509.6.
DR Ensembl; ENSDART00000182708.1; ENSDARP00000146779.1; ENSDARG00000109849.1.
DR Ensembl; ENSDART00000190680.1; ENSDARP00000146413.1; ENSDARG00000112566.1.
DR GeneID; 100002125; -.
DR KEGG; dre:100002125; -.
DR AGR; ZFIN:ZDB-GENE-090312-188; -.
DR CTD; 6865; -.
DR ZFIN; ZDB-GENE-090312-188; tacr2.
DR eggNOG; KOG4219; Eukaryota.
DR HOGENOM; CLU_009579_6_1_1; -.
DR OMA; YQIAMII; -.
DR OrthoDB; 2912851at2759; -.
DR Reactome; R-DRE-380095; Tachykinin receptors bind tachykinins.
DR Reactome; R-DRE-416476; G alpha (q) signalling events.
DR Proteomes; UP000000437; Alternate scaffold 13.
DR Proteomes; UP000000437; Chromosome 13.
DR Bgee; ENSDARG00000074509; Expressed in swim bladder and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0097225; C:sperm midpiece; IBA:GO_Central.
DR GO; GO:0016497; F:substance K receptor activity; IBA:GO_Central.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR000913; NK2_rcpt.
DR PANTHER; PTHR46925; G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED; 1.
DR PANTHER; PTHR46925:SF3; SUBSTANCE-K RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01025; NEUROKININ2R.
DR PRINTS; PR00244; NEUROKININR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601681-50};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:NP_001314788.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..307
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DISULFID 107..182
FT /evidence="ECO:0000256|PIRSR:PIRSR601681-50"
SQ SEQUENCE 376 AA; 43907 MW; 9EC523A69341FFB5 CRC64;
MDTTLDPLSS SLLYYDEDGN ETSINLFEQP DWQVALWAIA YTLIVIISFI GNVTVIWIIL
AHKRMRTVTN YFIVNLAFSD ASMATFNTVF NFVYALHNDW YFGLGYCKFQ NFFPITAMFS
SIYSMAAIAV DRYMAIIHPL KPRLSSTTTK LLIGVIWTVA FSLAFPQCYY ASTKFYFPRT
VCMVEWPDDY GGKHQLSYQI AVIILIYLLP LLVMLVTYSL VGQRLWGSEI PGEASDHYQN
QMQAKRKVVK MMIVVVTTFA ICWLPYHIYF ILGSFNRDIY KQHYIQQVYL AIFWLAMSST
MYNPIIYCCL NQRFRSGFRK AFQWCPFVKI SEEDNMELQH MRTFHMRRSY RTETTSVVVR
NHANEPEDTT SKLIKA
//
