ID F1QT18_DANRE Unreviewed; 435 AA.
AC F1QT18; A0A8M1P4L6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Tubulin--tyrosine ligase-like protein 9 {ECO:0000256|ARBA:ARBA00030445};
GN Name=ttll9 {ECO:0000313|Ensembl:ENSDARP00000108447,
GN ECO:0000313|RefSeq:NP_001243693.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-1582};
GN Synonyms=fb75c08 {ECO:0000313|RefSeq:NP_001243693.1}, si:dkey-211h10.2
GN {ECO:0000313|RefSeq:NP_001243693.1}, wu:fb75c08
GN {ECO:0000313|RefSeq:NP_001243693.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000108447};
RN [1] {ECO:0000313|RefSeq:NP_001243693.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21262966; DOI=10.1074/jbc.M110.209817;
RA Pathak N., Austin C.A., Drummond I.A.;
RT "Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish
RT cilia structure and motility.";
RL J. Biol. Chem. 286:11685-11695(2011).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000108447}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108447};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000108447, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000108447};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_001243693.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|RefSeq:NP_001243693.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [6] {ECO:0000313|RefSeq:NP_001243693.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tubulin--tyrosine ligase family.
CC {ECO:0000256|ARBA:ARBA00006820}.
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DR EMBL; AL929345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001243693.1; NM_001256764.1.
DR STRING; 7955.ENSDARP00000108447; -.
DR PaxDb; 7955-ENSDARP00000127671; -.
DR Ensembl; ENSDART00000128551; ENSDARP00000108447; ENSDARG00000062806.
DR Ensembl; ENSDART00000128551.4; ENSDARP00000108447.2; ENSDARG00000062806.8.
DR GeneID; 556794; -.
DR KEGG; dre:556794; -.
DR AGR; ZFIN:ZDB-GENE-030131-1582; -.
DR CTD; 164395; -.
DR ZFIN; ZDB-GENE-030131-1582; ttll9.
DR eggNOG; KOG2157; Eukaryota.
DR OMA; IWIMKPP; -.
DR OrthoDB; 7265at2759; -.
DR PhylomeDB; F1QT18; -.
DR TreeFam; TF313087; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000062806; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF39; TUBULIN POLYGLUTAMYLASE TTLL9-RELATED; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 51140 MW; 69F0F71F1D6AA819 CRC64;
MSKNKQTTGH KAAHSSQRKK EVEARSCIRY RCGLTNTIQD VLNHRPGWVE VKDDAEWDFN
WCDVGWLREN FDHSYMEEHV RICHFRNHYE LTRKNLMVKN LKRYRKTLER EVGRLEAAKC
DFFPRTFELP SEYHIFVEEF KKSPGNTWIM KPVARSQGKG IFLFRKLKDI IDWRKDGSRS
EEQKDEAQVE SYVAQRYIEN PYLIAGRKFD LRVYVLVTSY IPLKAWLYRD GFARFSNTRF
SLSSIDDQYV HLTNVAVQKT APDYDPEKGC KWQMQQLRWY LTAKHGFETV QTLFKEIDNV
FIRSLLSVQK TIINDKHCFE LYGYDILLDQ DLKPWLIEVN ASPSLTASSQ EDYDLKYRLL
EDTLHIVDME GRLTGKEKRI GGFDLMWNDG PVYTDVGLEA LGSSCLVANT HLGCVNDREK
QLQQLLKPFP GQKKT
//
