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Database: UniProt
Entry: F1QWI1_DANRE
LinkDB: F1QWI1_DANRE
Original site: F1QWI1_DANRE 
ID   F1QWI1_DANRE            Unreviewed;       817 AA.
AC   F1QWI1; F8VNM8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 2.
DT   25-OCT-2017, entry version 43.
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 6b {ECO:0000313|Ensembl:ENSDARP00000088318};
DE   Flags: Fragment;
GN   Name=trpc6b {ECO:0000313|Ensembl:ENSDARP00000088318,
GN   ECO:0000313|ZFIN:ZDB-GENE-081030-19};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000088318, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000088318}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000088318};
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000088318, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000088318,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000088318}.
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DR   EMBL; CU459064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000088318; -.
DR   PaxDb; F1QWI1; -.
DR   Ensembl; ENSDART00000097547; ENSDARP00000088318; ENSDARG00000067730.
DR   ZFIN; ZDB-GENE-081030-19; trpc6b.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; F1QWI1; -.
DR   OMA; SHICFLV; -.
DR   OrthoDB; EOG091G01FB; -.
DR   TreeFam; TF313147; -.
DR   Reactome; R-DRE-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-DRE-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-DRE-3295583; TRP channels.
DR   Proteomes; UP000000437; Chromosome 18.
DR   Bgee; ENSDARG00000067730; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005462; TRPC6_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 2.
DR   PANTHER; PTHR10117:SF7; PTHR10117:SF7; 2.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    334    354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    366    386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    435       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    455    478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    518    539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    559    581       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    630    652       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       32     82       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      786    810       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSDARP00000088318}.
SQ   SEQUENCE   817 AA;  93707 MW;  C8947338DB720A4A CRC64;
     XKSRRMAMRR PAHMFNARYN NLSPTEERFL EAAEYGNIPV IRRMLEELPE LNVNCVDYMG
     QNALQLAVAN EHLEVTELLL KKENLARIGD ALLLAISKGY IRIVEAILSH QAFADTTKLT
     SSPLQAETQD DFFAYDEDGT RFSHDITPII LASHCHEYEI VHILLRKGAC IARPHDYFCK
     CNGCLYHQRH DSFSHSRSRI NAYKGLASPA YLSLSSEDPV LTALELSNEL AVLANIEKEF
     KNDYKTLSMQ CKDFVVGLLD LCRNTEEVEA ILNGDTEAGG HFDKGDRPNL VRLKLAIKYE
     LKKFVAHPNC QQQLLSIWYE NLSGLRQQTT AVKLLVVLGV VVGLPILALL YWIAPSSKLG
     KIIRGPFLKF VAHAASFTIF LGLLIMNAAD RFEGTSLLPN MTIHDHPSQL FRMKTTPFTW
     MEMLIISWVV GMIWAECKEI WSLGPREYLL EPWNLLDFGM LAIFVTSFIA RFMAFYHANV
     AQNYVDKRYT DLSNITLPLE IEYYRLARVH WVPSDPQLIS EGLYAIAVVL SFSRIAYILP
     ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL YSYYRGAKQN GAFTTVEESF
     KTLFWAIFGL SEVKSVVINN GHKFIENIGY VLYGVYNVTM VIVLLNMLIA MINNSFQEIE
     DDADVEWKFA RAKLWFSYFE EGGTLPVPFN LIPSPKSVIS LAMRLKRLLL IPLHRHKEDL
     KEDTELNESG KQKESSEKNS PHTSRYQRIM KRLIKRYVIK AQTDKEGDEV NEGELKEIKQ
     DISSLRFELL EEKSRQTEEL AELVRRLEER LISQYKI
//
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