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Database: UniProt
Entry: F1QXF5_DANRE
LinkDB: F1QXF5_DANRE
Original site: F1QXF5_DANRE 
ID   F1QXF5_DANRE            Unreviewed;      1996 AA.
AC   F1QXF5;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   22-NOV-2017, entry version 57.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=scn1lab {ECO:0000313|Ensembl:ENSDARP00000085427,
GN   ECO:0000313|ZFIN:ZDB-GENE-060906-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000085427, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000085427}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000085427};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000125843}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000125843};
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000085427, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000085427,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000085427}.
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DR   EMBL; BX511272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR396591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001038360.2; NM_001044895.2.
DR   RefSeq; XP_005165827.1; XM_005165770.3.
DR   RefSeq; XP_009300461.1; XM_009302186.2.
DR   RefSeq; XP_009300463.1; XM_009302188.2.
DR   UniGene; Dr.87125; -.
DR   STRING; 7955.ENSDARP00000125843; -.
DR   Ensembl; ENSDART00000090994; ENSDARP00000085427; ENSDARG00000062744.
DR   Ensembl; ENSDART00000151247; ENSDARP00000125843; ENSDARG00000062744.
DR   GeneID; 559447; -.
DR   CTD; 559447; -.
DR   ZFIN; ZDB-GENE-060906-1; scn1lab.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; CMSNHTT; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000000437; Chromosome 6.
DR   Bgee; ENSDARG00000062744; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IMP:ZFIN.
DR   GO; GO:0006110; P:regulation of glycolytic process; IMP:ZFIN.
DR   GO; GO:0002082; P:regulation of oxidative phosphorylation; IMP:ZFIN.
DR   GO; GO:0036269; P:swimming behavior; IMP:ZFIN.
DR   GO; GO:0099536; P:synaptic signaling; IMP:ZFIN.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    126    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    194    213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    390    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    743    761       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    773    796       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    808    832       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    853    881       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    943    966       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1200   1218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1239   1258       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1270   1290       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1316   1342       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1441   1464       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1523   1541       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1553   1571       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1583   1603       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1640   1668       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1744   1767       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    423       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      492    692       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      743    970       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      980   1193       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1198   1473       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1522   1777       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      414    459       {ECO:0000256|SAM:Coils}.
FT   COILED      481    503       {ECO:0000256|SAM:Coils}.
FT   COILED     1967   1994       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1996 AA;  226393 MW;  E3735ECF55FF2A74 CRC64;
     MAAQLLVPPG PDSFRPFLPE SLAAIEQRIA EEVAQRPKGE RRPDDDDENG PKPNRDLEAG
     KPLPFIYGDV PPHMLSVPLE DLDTYYSNQK TFIVLNRGKA IFRFNATPAL YILSPFNPLR
     RISIRVLVHS LFSFVIMCTI LTNCAFMTLS NPPEWAKNVE YTFTGIYTFE SLIKILARGF
     CVGKFTFLRD PWNWLDFSVI LMAYVTEFVN LGNVSALRTF RVLRALKTIS VIPGLKTIVG
     ALIQSVKKLS DVMILTVFCL SVFALIGLQL FMGNLRQKCV KMPEVNVTDN LTDYSTELHN
     STFNWTEYIS DSNNYYFIPG RRDALLCGNS SDAGQCPEGF TCIKAGRNPD YGYTSFDTFS
     WAFLSLFRLM TQDFWENLYQ QTLRAAGKPY MIFFVLVIFL GSFYLVNLIL AVVAMAYDEQ
     NQATIEEAQQ KEEEFQAMLE QLKRQQEEAQ VAAAAATESG EYSGRGGLSE ESSSGGSRLS
     SKSAKERRNR RKKRKQREEE EKADQEKFHK SASEDSIRRP GFRFSIDANR LSYEKKCSTP
     NQSLLSIRGS LFSPRRNSRA SLFSFRGRAR DFGSENDFAD DEHSTFEDSD SRRGSLFVPR
     CVERRSSTVS HCSLTAPRIM LPANGKMHCT VDCNGVVSLV GGTSVPTSPI GRLLPEGTTT
     ESDVRKKRSG SHQPSDYLEE TVARKRAMSV ASILTNTMEE LEESRQKCPP CWYKFANSFL
     IWDCSPAWLK VKEIMNMIVM DPFVDLAITI CIVLNTLFMA MEHYPMTTQF SHLLSVGNLV
     FTGIFTAEMC LKVIALDPYY YFQEGWNIFD GIIVSLSLME LGLANVEGLS VLRSFRLLRV
     FKLAKSWPTL NMLIKIIGNS VGALGNLTLV LAIIVFIFAV VGMQLFGKSY RECVCKISES
     CELPRWHMDD FFHSFLIVFR VLCGEWIETM WDCMEVAGQS MCLIVFMMVM VIGNLVVLNL
     FLALLLSSFS ADNLAATDDD SEMNNLQIAV GRIQKGIALV KSTLRQFLQS LFLAGSKPRS
     LDEEKPLDDL HSDGKENCLS NHAPVAVDLT KDYLKEGCVS PGNGVESHVK YGIEEGDYMS
     FIHNPSLTVT VPIAVGESDF ENLNTEDFSS ESSDVEGSKE KLPVDTVLSS SEGSTVDIRP
     PGEGAESVEL EPEESLDPEA CFTEGCVMRF QCCQVDVEKG KWKSWWILRK TCFIIVEHNW
     FESFIIFMIL LSSGALAFED IYIEQRKTIK TVLEYADKVF TYIFILEMLL KWVAYGFAKY
     FTNAWCWLDF LIVDVSLVSL VANALGYSEL SAIKSLRTLR ALRPLRALSR FEGMRVVVNA
     LLGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKYYYCVNI TNDELFPVSV VNNKSDCYAL
     IQNNDTARWK NVKINFDNVG AGYLALLQVA TFKGWMDIMY AAVDSRDLEQ QPVYETNLYM
     YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKLGGQDIF MTEEQKKYYN AMKKLGSKKP
     QKPIPRPANK FQGLVFDLIT KQAFDIIIMI LICLNMVTMM VETDDQTEDM DNILYWINLV
     FIILFTGECV LKMISLRHYF FTIGWNVFDF VVVILSIVGM FLSEMIEKYF VSPTLFRVIR
     LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM SNFAYVKREA
     GIDDMFNFET FGNSMLCLFQ ITTSAGWDGL LAPILNKQDP DCDSEMEHPG SFYRGNCGNP
     SVGIFFFVSY IIICFLIVVN MYIAVILENF SVATEESAEP LSEDDFEMFY EVWERFDPNA
     TQFVEYNKLS DFADALDPPL RIAKPNKIQL IAMDLPMVSG DRIHCLDILF AFTLRVLGEE
     GEMDALRGQM EDRFMASNPS KVSYEPITTT LRRKQEEMSA VVIQRAFRRH RIRQTVKKAS
     EAYRKQLQDG GGHIPEKEVL VIGKFQENSA SDKTDMTPSS ASPPSYNSVA KSEKDKYEKE
     RREKEDKAKD ARDRKK
//
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