ID F1QYV0_DANRE Unreviewed; 665 AA.
AC F1QYV0; A0A8M1N4K3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Tetratricopeptide repeat domain 14 {ECO:0000313|Ensembl:ENSDARP00000018028};
DE SubName: Full=Tetratricopeptide repeat protein 14 {ECO:0000313|RefSeq:NP_001014336.2};
GN Name=ttc14 {ECO:0000313|Ensembl:ENSDARP00000018028,
GN ECO:0000313|RefSeq:NP_001014336.2,
GN ECO:0000313|ZFIN:ZDB-GENE-050327-26};
GN Synonyms=zgc:113259 {ECO:0000313|RefSeq:NP_001014336.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000018028};
RN [1] {ECO:0000313|RefSeq:NP_001014336.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001014336.2};
RX PubMed=12477932; DOI=10.1073/pnas.242603899;
RG Mammalian Gene Collection Program Team;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D.,
RA Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F.,
RA Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H.,
RA Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K.,
RA Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F.,
RA Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S.,
RA Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J.,
RA Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J.,
RA Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M.,
RA Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C.,
RA Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I.,
RA Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human and
RT mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000018028}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000018028};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000018028, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000018028};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_001014336.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001014336.2};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|RefSeq:NP_001014336.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001014336.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU468728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU611042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001014336.2; NM_001014314.2.
DR STRING; 7955.ENSDARP00000018028; -.
DR PaxDb; 7955-ENSDARP00000018028; -.
DR Ensembl; ENSDART00000028085; ENSDARP00000018028; ENSDARG00000013845.
DR Ensembl; ENSDART00000028085.4; ENSDARP00000018028.3; ENSDARG00000013845.6.
DR GeneID; 541501; -.
DR KEGG; dre:541501; -.
DR AGR; ZFIN:ZDB-GENE-050327-26; -.
DR CTD; 151613; -.
DR ZFIN; ZDB-GENE-050327-26; ttc14.
DR eggNOG; ENOG502QPJ1; Eukaryota.
DR HOGENOM; CLU_020585_1_0_1; -.
DR OMA; IRKEEWY; -.
DR OrthoDB; 2918730at2759; -.
DR PhylomeDB; F1QYV0; -.
DR TreeFam; TF325777; -.
DR Proteomes; UP000000437; Chromosome 22.
DR Bgee; ENSDARG00000013845; Expressed in brain and 19 other cell types or tissues.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039190; TTC14.
DR PANTHER; PTHR23184; TETRATRICOPEPTIDE REPEAT PROTEIN 14; 1.
DR PANTHER; PTHR23184:SF9; TETRATRICOPEPTIDE REPEAT PROTEIN 14; 1.
DR Pfam; PF13414; TPR_11; 1.
DR SMART; SM00316; S1; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50005; TPR; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1QYV0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 115..197
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REPEAT 330..363
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 452..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..511
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 75229 MW; A293EBB056D9A367 CRC64;
MDRDLLRQSV SFHGENLLSL LKCEQNENPD FKHLASDLYK SLNQRDKDEQ SPVLEQFIAR
KADLLFAPSW KISEPADEWQ EESGEAFAVM PPLEQFMEVS FEERRELFYR DVERGDMVIG
RINSVRDFGL FVTLLCTAGG LKRDIEDLEI KALCPKREVP STGNHDDPLS YYQIGDLIRA
GVKDIDRYHE KLTLSLHSSS VSPHMEKVKL GVLNKEDLPL HYTRGEIVSS DSNETFEKLL
DDSLGLSNPL NVDFLLGKLG ISDTQTPSLM RGLQSKRFKE EDFATTIRKK QSVSWALKCV
KTGVGHFKSG RHVDAMNEYN KALEIDTNNV EALVARGALY ATKGSLVKAI EDFELALENC
PTHRNAKKYL CQTLVERGGQ VEEEEKLVTA ESLYKRALVL DDTFKEAAEV LEKLQIRIQK
SLKLKELEAA KEQEKAKTAE TSAEKLRKIL KEEKRMKKKR KRSTSSSTSS DSSSSSSSDS
SPSTSRKKSK KRKHKRRRSS RSSKKHKRRV SSCSDKTAED DRDWFPAPAN TSASYINQNQ
SISKLMSESE PVWGAESRGR FEEDLERGSD QVKPAGFRSG VNGEPLKVNE RVGNRRDSSS
STQSEYSHKS ERHSEFSGRN PSRSERAGND GGKTNSANTK KDLPLNLLDI FSQIAEFQKD
KKQKK
//
