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Database: UniProt
Entry: F1R3Q5_DANRE
LinkDB: F1R3Q5_DANRE
Original site: F1R3Q5_DANRE 
ID   F1R3Q5_DANRE            Unreviewed;      1932 AA.
AC   F1R3Q5;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   22-NOV-2017, entry version 55.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=scn12aa {ECO:0000313|Ensembl:ENSDARP00000107413,
GN   ECO:0000313|ZFIN:ZDB-GENE-060908-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000107413, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000107413}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107413};
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000107413, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107413,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000107413}.
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DR   EMBL; BX248231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX908782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU929148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009297177.1; XM_009298902.2.
DR   STRING; 7955.ENSDARP00000077691; -.
DR   PaxDb; F1R3Q5; -.
DR   Ensembl; ENSDART00000128198; ENSDARP00000107413; ENSDARG00000090724.
DR   CTD; 795688; -.
DR   ZFIN; ZDB-GENE-060908-2; scn12aa.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000000437; Chromosome 2.
DR   Bgee; ENSDARG00000090724; -.
DR   ExpressionAtlas; F1R3Q5; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR   GO; GO:0003007; P:heart morphogenesis; IMP:ZFIN.
DR   GO; GO:0008016; P:regulation of heart contraction; IMP:ZFIN.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     99    118       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    391    418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    706    724       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    736    759       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    816    844       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    904    929       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1128   1147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1168   1184       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1196   1215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1260   1280       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1367   1390       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1449   1467       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1479   1501       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1513   1532       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1580   1602       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1670   1693       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    424       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      511    604       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      706    934       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      943   1123       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1127   1398       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1448   1703       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1032   1055       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1932 AA;  220516 MW;  1FDE36323DC1228F CRC64;
     MATMLLPAGP DGLRPFTRES LAAIEQRISE ERARNTKDYK ADPGDVEEPK PRADLEVGKV
     LPRIFGEIPA GLVGVPLEDI DPFYFRNQKT FIVLNKGKAI FRFSATSALY IFSPFHCIRR
     ISIRILVHSL FSLFIMCTIL TNCCFMAMSD PPLWTKYLEY TFTGIYTFES LIKILARGFC
     TECFTFLRDP WNWLDFSVIV MAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLAD VMILTVFCLS VFALIGLQLF MGILRQKCVR SIGHCVNSTY PGNGSFVCNN
     KTWLSVKDFL TNEDNFYKIE GSKDALICGY SSDAGKCPDG FDCLKTSRNP NYGYTSFDTF
     GWAFLGLFRL MTQDYWESLY HQTLRSAGKT YMIFFVLVIF LGSFYLVNLI LAVVAMAYEE
     QNQATIAEAW AKEREFQLAM EHLRKEQRAL AKQRRKEAEM ALAADFCPSP FSRKDSIKCR
     TRTRSHRTLS EEIEDSFLPK FEPLDEKPAH PLLATLSSHP LSTRRGSQMS IFTFRPRNSS
     EADFADDEHS VADYGRSRAG SMATPWHKHR TGSIRSHSSQ VFTPTLANGR LNISLEQNGI
     TGIGLHTPTT GPKFSMEKVK EGTEPECQNE QVKLTVDVQE EVLPPRRKRG LSSVSFFSDA
     MDELEEARQK CPPCWYEFAQ KYLIWTCSPA WLRVKEGLKV MVMDPFLDLA ITICIVLNTL
     FMALEHYPMT DEFNSMLSIG NLVFTGIFTA EMVLKIFALD PYYYFQQGWN IFDGIIVCLS
     LMELGLSNVE GLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL TLVLAIIVFI
     FAVVGMQLFG KNYQDCVCKI SYDCTLPRWH MKDFFHSFLI VFRVLCGEWI ETMWDCMEVA
     GQPLCILVFM LVMVIGNLVV LNLFLALLLS SFSSDNLSAP DEDGEMNNLQ IAIARIHCGF
     SWLLNGIKDL FSGNLTRHRR KSKEAQVTLN HTECNGGLGS LEKYVFPETE DSYMTNPNLT
     ICVPIAPGES DVEFLEEEEE EEDTESSEDE EEKQEVISLS EGSTVDLRKP GEDEEEYSEM
     ADDGMDPEEC FPEFCMQRCK CCNINTTQGL GQMWWRLRKT CYQIVEHSWF ETFIIFMILL
     SSGALAFEDI YIEQRKVVKV VLEYADKVFS YIFVLEMFLK WIAYGFKKYF TNYWCWLDFL
     IVDVSLISLV ANSLGYSDFG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL IGAIPSIMNV
     LLVCLIFWLI FSIMGVNLFA GKFGKCVNRT GFIHNASIVN NKTECLSMND TQFYWTKVKV
     NFDNVGLGYL SLLQVATFKG WMEIMYAAVD SRGVEDQPIK EINLYMYLYF VIFIIFGSFF
     TLNLFIGVII DNFNQQKRMI GGQDIFMTEE QKKYYNAMKK LGSKKPQKPI PRPMNILQGF
     FFDLVSKQAF DITIMMLIIL NMITMMVETD EQSARMETIL NNINLAFIVI FTTECLIKIF
     ALRCYFFTIS WNIFDFVVVI LSIVGIVLAD IIEKYFVSPT LFRVIRLARI GRVLRLIRAA
     KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YAIFGMANFA YVKKQGGIDD MFNFETFGNS
     MICLFQITTS AGWNNLLDPI LNNSPEECSS SFANTGTNTK GNCGHPSVGI TFFVSYIIIS
     FLIVVNMYIA IILENFSVAT EESTEPLSED DFEMFYEVWE KFDVEATHFI EYAKLSNFAD
     SLSEPLRIAK PNKIKLIHMD LPMVNGDRIH CLDILFAFTK RVLGETGEMD ALKQQMEEKF
     MVTNPSKISH EPITTTLRRK QEEISATLIQ RAYRAHLIRR QMKQASYLYR HINQETPWSE
     EDSAPEQEGL IASMIKENYG PEKMVGTLCY ASSPPSYEAV TRSPRDHFKL LISDSRSNEP
     HKSEETYEET FL
//
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