ID F1R8W4_DANRE Unreviewed; 473 AA.
AC F1R8W4; A0A8N7UZE8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Desmin {ECO:0000256|ARBA:ARBA00040601};
GN Name=desma {ECO:0000313|Ensembl:ENSDARP00000075991,
GN ECO:0000313|RefSeq:NP_571038.2, ECO:0000313|ZFIN:ZDB-GENE-980526-221};
GN Synonyms=cb290 {ECO:0000313|RefSeq:NP_571038.2}, des
GN {ECO:0000313|RefSeq:NP_571038.2}, desm
GN {ECO:0000313|RefSeq:NP_571038.2}, wu:fb59a12
GN {ECO:0000313|RefSeq:NP_571038.2}, zgc:109859
GN {ECO:0000313|RefSeq:NP_571038.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000075991};
RN [1] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=12366382;
RA Chen Y.H., Tsai H.J.;
RT "Treatment with Myf5-morpholino results in somite patterning and brain
RT formation defects in zebrafish.";
RL Differentiation 70:447-456(2002).
RN [2] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=12128209;
RA Costa M.L., Escaleira R.C., Rodrigues V.B., Manasfi M., Mermelstein C.S.;
RT "Some distinctive features of zebrafish myogenesis based on unexpected
RT distributions of the muscle cytoskeletal proteins actin, myosin, desmin,
RT alpha-actinin, troponin and titin.";
RL Mech. Dev. 116:95-104(2002).
RN [3] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=15042708; DOI=10.1002/dvdy.10454;
RA Amali A.A., Lin C.J., Chen Y.H., Wang W.L., Gong H.Y., Lee C.Y., Ko Y.L.,
RA Lu J.K., Her G.M., Chen T.T., Wu J.L.;
RT "Up-regulation of muscle-specific transcription factors during embryonic
RT somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1.";
RL Dev. Dyn. 229:847-856(2004).
RN [4] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=15644413; DOI=10.1182/blood-2004-09-3547;
RA Patterson L.J., Gering M., Patient R.;
RT "Scl is required for dorsal aorta as well as blood formation in zebrafish
RT embryos.";
RL Blood 105:3502-3511(2005).
RN [5] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=15732137;
RA Bosworth CA 4.t.h., Chou C.W., Cole R.B., Rees B.B.;
RT "Protein expression patterns in zebrafish skeletal muscle: initial
RT characterization and the effects of hypoxic exposure.";
RL Proteomics 5:1362-1371(2005).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000075991}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000075991};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [7] {ECO:0000313|Ensembl:ENSDARP00000075991, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000075991};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=28605648;
RA Falisse E., Voisin A.S., Silvestre F.;
RT "Impacts of triclosan exposure on zebrafish early-life stage: Toxicity and
RT acclimation mechanisms.";
RL Aquat. Toxicol. 189:97-107(2017).
RN [9] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=29311262; DOI=10.1242/dev.156869;
RA Trivedi V., Choi H.M.T., Fraser S.E., Pierce N.A.;
RT "Multidimensional quantitative analysis of mRNA expression within intact
RT vertebrate embryos.";
RL Development 145:dev156869-dev156869(2018).
RN [10] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=29945667; DOI=10.1186/s13064-018-0112-y;
RA Ghosh P., Maurer J.M., Sagerstrom C.G.;
RT "Analysis of novel caudal hindbrain genes reveals different regulatory
RT logic for gene expression in rhombomere 4 versus 5/6 in embryonic
RT zebrafish.";
RL Neural Dev. 13:13-13(2018).
RN [11] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=29518074;
RA Bennett A.H., O'Donohue M.F., Gundry S.R., Chan A.T., Widrick J.,
RA Draper I., Chakraborty A., Zhou Y., Zon L.I., Gleizes P.E., Beggs A.H.,
RA Gupta V.A.;
RT "RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by
RT modulation of translational processes.";
RL PLoS Genet. 14:e1007226-e1007226(2018).
RN [12] {ECO:0000313|RefSeq:NP_571038.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RX PubMed=29777134;
RA Hsieh F.C., Lu Y.F., Liau I., Chen C.C., Cheng C.M., Hsiao C.D.,
RA Hwang S.L.;
RT "Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of
RT cardiomyocytes and epicardial cells.";
RL Sci. Rep. 8:7856-7856(2018).
RN [13] {ECO:0000313|RefSeq:NP_571038.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571038.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cytoplasm, myofibril, sarcomere, Z
CC line {ECO:0000256|ARBA:ARBA00004216}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; CU861474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_571038.2; NM_130963.2.
DR Ensembl; ENSDART00000081550; ENSDARP00000075991; ENSDARG00000058656.
DR Ensembl; ENSDART00000081550.6; ENSDARP00000075991.4; ENSDARG00000058656.6.
DR GeneID; 30148; -.
DR AGR; ZFIN:ZDB-GENE-980526-221; -.
DR ZFIN; ZDB-GENE-980526-221; desma.
DR HOGENOM; CLU_012560_7_4_1; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000058656; Expressed in cardiac ventricle and 32 other cell types or tissues.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IDA:ZFIN.
DR GO; GO:0060047; P:heart contraction; IMP:ZFIN.
DR GO; GO:0007626; P:locomotory behavior; IMP:ZFIN.
DR GO; GO:0006936; P:muscle contraction; IGI:ZFIN.
DR GO; GO:0030239; P:myofibril assembly; IMP:ZFIN.
DR GO; GO:0010522; P:regulation of calcium ion transport into cytosol; IMP:ZFIN.
DR GO; GO:0055117; P:regulation of cardiac muscle contraction; IMP:ZFIN.
DR GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IMP:ZFIN.
DR GO; GO:0045214; P:sarcomere organization; IMP:ZFIN.
DR GO; GO:0060538; P:skeletal muscle organ development; IGI:ZFIN.
DR GO; GO:0007519; P:skeletal muscle tissue development; IMP:ZFIN.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652:SF2; DESMIN; 1.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1R8W4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 102..410
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 421..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 106..261
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 294..388
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 473 AA; 54149 MW; 9A46C8CF7375FFE8 CRC64;
MSTKYSASAE SASSYRRTFG SGLGSSIFAG HGSSGSSGSS RLTSRVYEVT KSSASPHFSS
HRASGSFGGG SVVRSYAGLG EKLDFNLADA INQDFLNTRT NEKAELQHLN DRFASYIEKV
RFLEQQNSAL TVEIERLRGR EPTRIAELYE EEMRELRRQV EALTNQRSRV EIERDNLVDD
LQKLKLRLQE EIHQKEEAEN NLSAFRADVD AATLARLDLE RRIEGLHEEI AFLRKIHEEE
IRELQNQMQE SQVQIQMDMS KPDLTAALRD IRLQYEAIAA KNISEAEDWY KSKVSDLNQA
VNKNNEALRE AKQETMQFRH QLQSYTCEID SLKGTNESLR RQMSEMEERL GREAGGYQDT
IARLEAEIAK MKDEMARHLR EYQDLLNVKM ALDVEIATYR KLLEGEESRI SLPVQSFSSL
SFRESSPEQH HHQQQQPQRS SEVHSKKTVL IKTIETRDGE VVSESTQHQQ DVM
//