ID F1RBY1_DANRE Unreviewed; 837 AA.
AC F1RBY1; A0A8M6Z0N0; F6NHG9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=A kinase (PRKA) anchor protein 1b {ECO:0000313|Ensembl:ENSDARP00000099189};
DE SubName: Full=A-kinase anchor protein 1, mitochondrial {ECO:0000313|RefSeq:NP_001091649.2, ECO:0000313|RefSeq:XP_017206451.1};
GN Name=akap1b {ECO:0000313|Ensembl:ENSDARP00000099189,
GN ECO:0000313|RefSeq:NP_001091649.2, ECO:0000313|RefSeq:XP_017206451.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-6844};
GN Synonyms=akap1 {ECO:0000313|RefSeq:NP_001091649.2,
GN ECO:0000313|RefSeq:XP_017206451.1}, fa08b04
GN {ECO:0000313|RefSeq:NP_001091649.2,
GN ECO:0000313|RefSeq:XP_017206451.1}, wu:fa08b04
GN {ECO:0000313|RefSeq:NP_001091649.2,
GN ECO:0000313|RefSeq:XP_017206451.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000099189};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000099189}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000099189};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000115383}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000115383};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:NP_001091649.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001091649.2};
RX PubMed=24240475;
RA Huang H.T., Kathrein K.L., Barton A., Gitlin Z., Huang Y.H., Ward T.P.,
RA Hofmann O., Dibiase A., Song A., Tyekucheva S., Hide W., Zhou Y., Zon L.I.;
RT "A network of epigenetic regulators guides developmental haematopoiesis in
RT vivo.";
RL Nat. Cell Biol. 15:1516-1525(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000099189, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000099189};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001091649.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001091649.2};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_001091649.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001091649.2};
RX PubMed=26767746;
RA Zhou S., Zhao H., Thongda W., Zhang D., Su B., Yu D., Peatman E., Li C.;
RT "Galectins in channel catfish, Ictalurus punctatus: Characterization and
RT expression profiling in mucosal tissues.";
RL Fish Shellfish Immunol. 49:324-335(2016).
RN [7] {ECO:0000313|RefSeq:NP_001091649.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001091649.2};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [8] {ECO:0000313|RefSeq:NP_001091649.2, ECO:0000313|RefSeq:XP_017206451.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001091649.2,
RC ECO:0000313|RefSeq:XP_017206451.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; BX000438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001091649.2; NM_001098179.2.
DR RefSeq; XP_017206451.1; XM_017350962.2.
DR STRING; 7955.ENSDARP00000115383; -.
DR PaxDb; 7955-ENSDARP00000023057; -.
DR Ensembl; ENSDART00000112511.2; ENSDARP00000099189.2; ENSDARG00000006062.8.
DR Ensembl; ENSDART00000138988.3; ENSDARP00000115383.1; ENSDARG00000006062.8.
DR GeneID; 556208; -.
DR KEGG; dre:556208; -.
DR AGR; ZFIN:ZDB-GENE-030131-6844; -.
DR CTD; 556208; -.
DR ZFIN; ZDB-GENE-030131-6844; akap1b.
DR eggNOG; KOG2279; Eukaryota.
DR HOGENOM; CLU_016731_0_0_1; -.
DR OMA; NTKPSNM; -.
DR OrthoDB; 4118571at2759; -.
DR TreeFam; TF105401; -.
DR Reactome; R-DRE-983231; Factors involved in megakaryocyte development and platelet production.
DR Proteomes; UP000000437; Chromosome 15.
DR Bgee; ENSDARG00000006062; Expressed in cardiac ventricle and 37 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22395; KH-I_AKAP1; 1.
DR CDD; cd20407; Tudor_AKAP1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR047368; KH-I_AKAP1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047367; Tudor_AKAP1.
DR PANTHER; PTHR22948:SF65; A-KINASE ANCHOR PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00322; KH; 1.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50304; TUDOR; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1RBY1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 695..754
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 35..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 89864 MW; D5D6AB93E5AC523F CRC64;
MPLRFRSFVP YTLPGVLALI GWWWYISRKK ERITSHDSEE DSLMGLRTSS GEGSNGMVDK
SCPASSSTHR KTSQDRVKAK EHRPVEQEVV AEIHTPVLKA TAGEALGTPP VVLASGQLSA
PHSGTKSVPP KSHPETTSQT TPVSSSTPTK TVEETPHHKG PDVATDARPS SQLPPASTDS
IKKQVENQTL TSQRSVELAK AERPEPEGEV ATESLATTCA QNLQADISKD ELASTISSTE
SEAVLLETCS PKTPLNLTSF PNSTSTPLSE SSTGAQHHEN GDLGLPAETS PDLQELQRLA
AGLITEVISA ATQEVMAVSS CESRYSKGSE ASDDSTLALN GKEESSQLPK SAESRAAQIA
EEIVNGCLAP SLWKMPENEK DRGLLSVPSG EQLESTPTLA KLQAEEALVE DSGCSTCQSE
DGVSSEDLHS TGLSSTVSES KEDLIQISGT CKATEGQEDR LHESLALIAP QESPLTAENV
ATVCEAARLN GTGLRNGAAS EVDADQSGGS DVNSMDSVDS CSTLGAGDGQ LSASQTCQSQ
SSELIVWEIE VPKHLVGRLI GKQGRYVSFL KQSSGAKIYI STLPYTQEFQ ICHIEGTQQQ
VDKALALIGK KFKDLDLTNL YAPPPPPLTL PSLPMTSWLL LPSGVTVEVI VVNIVSAGHV
FVQQHTHPTY HALRSLDQQM FLCYSQPGTP PLPSPVEVGV ICAAPAVDGA WWRAQVISFY
KDSTEVEIRY VDYGGYDRVK IDTLRQIRSD FVTLPFQGTE VLLDNIAPLP GEDRFSAEAN
SALEEMTRGV PLLAQVTNYD NNTGLPLVHM WNMVGEELVL LNRTLAERGF GTWVDSF
//
