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Database: UniProt
Entry: F1RCY2_DANRE
LinkDB: F1RCY2_DANRE
Original site: F1RCY2_DANRE 
ID   F1RCY2_DANRE            Unreviewed;       874 AA.
AC   F1RCY2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   25-OCT-2017, entry version 54.
DE   SubName: Full=Transient receptor potential cation channel subfamily c member 6a {ECO:0000313|EMBL:AGW27452.1};
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 6a {ECO:0000313|Ensembl:ENSDARP00000100760};
GN   Name=trpc6a {ECO:0000313|EMBL:AGW27452.1,
GN   ECO:0000313|Ensembl:ENSDARP00000100760,
GN   ECO:0000313|ZFIN:ZDB-GENE-040724-114};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000100760, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000100760}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000100760};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:AGW27452.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Wik {ECO:0000313|EMBL:AGW27452.1};
RX   PubMed=24038627; DOI=10.1002/dvdy.24041;
RA   Von Niederhausern V., Kastenhuber E., Stauble A., Gesemann M.,
RA   Neuhauss S.C.;
RT   "Phylogeny and expression of canonical transient receptor potential
RT   (TRPC) genes in developing zebrafish.";
RL   Dev. Dyn. 242:1427-1441(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000100760, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000100760,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; CU695000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF446635; AGW27452.1; -; mRNA.
DR   RefSeq; XP_005161247.1; XM_005161190.3.
DR   UniGene; Dr.48334; -.
DR   STRING; 7955.ENSDARP00000100760; -.
DR   Ensembl; ENSDART00000112175; ENSDARP00000100760; ENSDARG00000056625.
DR   GeneID; 563989; -.
DR   CTD; 563989; -.
DR   ZFIN; ZDB-GENE-040724-114; trpc6a.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   TreeFam; TF313147; -.
DR   Reactome; R-DRE-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-DRE-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-DRE-3295583; TRP channels.
DR   Proteomes; UP000000437; Chromosome 21.
DR   Bgee; ENSDARG00000056625; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AGW27452.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    388    408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    420    443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    472    489       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    509    530       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    613    636       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    684    706       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       88    232       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
SQ   SEQUENCE   874 AA;  100192 MW;  2F91E1B450B122A9 CRC64;
     MNQRRAVLED KNQSKYHSIE KRNRSKDNLL MNEHFGEDCY GSYGNYHGEN VARQVLPKSR
     RQAVRGAAYM FNGHPNSLTP LEERFLDAAE YGNIPVVRRM LEELPELDVN CVDYMGQNAL
     QLAVANEHLE VTELLLKKDN LSRIGDALLL AISKGYTRIV EAILSHKAFA DSRRLTASPS
     QAPMHDDFFA YDEDGTRFSH DVTPVILASH CHEYEIVHIL LGKGARIEQP HDYFCTCDTC
     NYHQKYDSFC HSRSRINAYR GLASPAYLSL SNEDPVLAAL ELSNELASLA NIEKEFKNEY
     RKLSMQCKDF VVGLLDLCRS TEEVEAILNG EEDDTLELPG RPSLIRLKLA IKYELKKFVA
     HPNCQQQLLS IWYEHLPELR QQTTAIKFLV VLGVAMGLPF LAMVYWVAPC SKMGKIMRGP
     FLKFVAHAAS FTIFLGLLVM NAADRFDGTK LLPNMTIHDY PTQLFRMKTT PFTWMEMLII
     SWVIGMIWAE CKEIWSQGPR EYLLEPWNLL DFGMLAIFVA SFISRIMAFW HASSAQRYVD
     EHYTDLTNVV LPFEVGYFQR ARIDWLPSDP QLVSEGLYAI AVVLSFSRIA YILPANESFG
     PLQISLGRTV KDIFKFMVIF ILVFLAFMIG MFNLYSYYRG AKQNEAFTTV EESFKTLFWA
     IFGLSEVKSV VVNNGHKFIE NIGYVLYGVY NVTVVIVLLN MLIAMINNSF QEIEDDADVE
     WKFARAKLWF TYFEEGRTLP VPFNLIPSPK SVLSLVMGVK GLLRELSVRQ KAIMKGSELS
     ELGQSKTCQA KTLPRSSRYQ KIMKRLVKRY IIKAQNDKEC DEVNEGELKE IKQDISSLRY
     ELLEEKSHNM EELAKLVRTL EKNLSQDCLV MKSH
//
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