ID F1RFN6_PIG Unreviewed; 1154 AA.
AC F1RFN6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX37 {ECO:0000313|Ensembl:ENSSSCP00000010420.4,
GN ECO:0000313|VGNC:VGNC:87293};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000010420.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000010420.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000010420.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000010420.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR AlphaFoldDB; F1RFN6; -.
DR Ensembl; ENSSSCT00000010698.5; ENSSSCP00000010420.4; ENSSSCG00000009758.5.
DR VGNC; VGNC:87293; DHX37.
DR eggNOG; KOG0926; Eukaryota.
DR GeneTree; ENSGT00550000074985; -.
DR HOGENOM; CLU_001832_0_0_1; -.
DR TreeFam; TF105654; -.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000009758; Expressed in hindlimb bud and 43 other cell types or tissues.
DR ExpressionAtlas; F1RFN6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0034511; F:U3 snoRNA binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:2000020; P:positive regulation of male gonad development; IEA:Ensembl.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:Ensembl.
DR GO; GO:0042255; P:ribosome assembly; IEA:Ensembl.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 251..418
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 448..705
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 128041 MW; 44959E1372E93945 CRC64;
MMGLHPHSSA GEEAPPPEEN DIDKGTLKGV DASNALVLPG KKKKKSKAPP LSKKEKKPLT
KKERKMLQRI LDQKEKKSQR AEMLQKLSEV QVSEAEMRLF YTTSKLGTGD RMYCTKEKPD
ELAAQGQKIS SLSGACRKRR HQDSEEEAEE EEGESSAESE LEEAPVAKRV EATEGMAPAH
LPPTLSGAGG QSPVPSNPAG TPAAPSAPPV TASALARPPA KPAIFIPVNR SPEMQEERLK
LPILAEEQVI MEAVAEHPIV IVCGETGSGK TTQVPQFLYE AGYSSDNSII GVTEPRRVAA
VAMSQRVAKE MNLSPRVVSY QIRYEGNVTE ETRIKFMTDG VLLKEIQKDF LLLKYKVLII
DEAHERSVYT DILIGLLSRI VCLRAKRHLP LKLLIMSATL RVEDFTQNQR LFAQPPPVIK
VESRQFPVTV HFNKRTPLED YSGECFRKVC KIHRMLPAGG ILVFLTGQAE VHALCRRLRR
AFPLARHRLP GNPKPKPLAQ EAGGGQPGLQ SFPQKSRPFT LPQISLDNYS VLPVGEGDED
REAEMDEEEE ALGSDLDLDL GDDGADGGEQ PDASIPLHVL PLYSLLAPEK QAQVFQPPPE
GTRLCVVATN VAETSLTIPG IKYVVDCGKV KKRHYDRVTG VSSFRVTWVS QASADQRAGR
AGRTEPGHCY RLYSSAVFED FEKFPPPEIT RRPVEDLILQ MKALNIEKVI NFPFPTPPSI
EALIAAEELL IALGALQAPP KTERMKQLQR SRLSCPITVL GRTMATFPVA PRYAKMLALS
RQHGCLPYAI TIVAAMTVRE LFEELDRPAA SDEELAKLKG KRARVAQMKR IWAGQGASLK
LGDLMVLLGA VGACEYSGCS LQFCEANGLR YKAMMEIRRL RGQLTTAVNA VCPEAGLFVD
PKMQPPSESQ VTYLRQIVTA GLGDHLARRV QSEDLLDEKW KNAYKTPLLD EPVFIHPSSV
LFKELPDFVV YQEIVETTKM YMKGVSTVEV QWIPVLLPSY CQFDKPLEEP PPTYCPEKGR
VQCHQAICVF WADPCAPDRV GWSLPAVQVD FPEGIDCYKH FARVLLDGQV FPKLASYKGC
LLSSPSTMLK TWARLQPRTE SLLRALVAEK ADCRDTLLAA WRKNPKYLLA EYCEWLPQAM
HADVEKGWPP TPDH
//
