ID F1RHP9_PIG Unreviewed; 484 AA.
AC F1RHP9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Tripartite motif containing 68 {ECO:0000313|Ensembl:ENSSSCP00000015688.4};
GN Name=TRIM68 {ECO:0000313|Ensembl:ENSSSCP00000015688.4,
GN ECO:0000313|VGNC:VGNC:94428};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000015688.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000015688.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000015688.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000015688.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1RHP9; -.
DR SMR; F1RHP9; -.
DR STRING; 9823.ENSSSCP00000015688; -.
DR PaxDb; 9823-ENSSSCP00000015688; -.
DR PeptideAtlas; F1RHP9; -.
DR Ensembl; ENSSSCT00000016119.5; ENSSSCP00000015688.4; ENSSSCG00000014768.5.
DR VGNC; VGNC:94428; TRIM68.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000162047; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; F1RHP9; -.
DR TreeFam; TF338674; -.
DR Proteomes; UP000008227; Chromosome 9.
DR Bgee; ENSSSCG00000014768; Expressed in adipose tissue and 45 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
DR GO; GO:0050681; F:nuclear androgen receptor binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0060765; P:regulation of androgen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR GO; GO:0046596; P:regulation of viral entry into host cell; IBA:GO_Central.
DR CDD; cd16610; RING-HC_TRIM68_C-IV; 1.
DR CDD; cd13733; SPRY_PRY_C-I_1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR042656; TRIM68_RING-HC.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF89; E3 UBIQUITIN-PROTEIN LIGASE TRIM68; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 16..61
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 93..134
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 285..482
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 484 AA; 55946 MW; A06B01440B5D4E0F CRC64;
MDPAALMEAV VEEVACPICM TFLKEPVSID CGHSFCHSCL SGLWEVPGEA PNWGYSCPLC
RAPVQPRNLR PNWQLANVAE KIRRLGLHPG MGLKGDVCEP HGQQLRMFCQ EDGLLMCEAC
SRAPEHEAHR VLPMEDVAWD YKWKLHEALE HLRKEHEEAW KLEVGERKRT ANWKIQVETR
KQSIMWEFEK YRRLLKKKQP PGRRLEVEAA AALASLEQEE GETARKLELN HDALIQQSRV
LWRMIAELED RSQRPVRWML QGIQDVLNRS QSWRLQRPEP VSLELKTDCR VPGLREILKT
FAADVRLDPD TAYSRLIVSE DRKCVRYGDT KQKLPDNERF YRYNIVLGSQ CISSGRHYWE
VEVGDRSEWG LGVCRESVDR KEVVYLSPHY GFWVIRLRKG SEYRAGTDEY PLLSLPVPPR
RVGVFLDYEA HDISFYNVTD NGAHIFTFPH YPFPGRLLPY FSPCYSIGAN NTAPLTICSL
DGED
//
