GenomeNet

Database: UniProt
Entry: F1RIC8_PIG
LinkDB: F1RIC8_PIG
Original site: F1RIC8_PIG 
ID   F1RIC8_PIG              Unreviewed;       386 AA.
AC   F1RIC8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN   Name=LOC100524300 {ECO:0000313|Ensembl:ENSSSCP00000013932.3};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000013932.3, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000013932.3, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000013932.3,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000013932.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F1RIC8; -.
DR   SMR; F1RIC8; -.
DR   STRING; 9823.ENSSSCP00000013932; -.
DR   MEROPS; A01.051; -.
DR   PaxDb; 9823-ENSSSCP00000013932; -.
DR   Ensembl; ENSSSCT00000014318.4; ENSSSCP00000013932.3; ENSSSCG00000013098.5.
DR   eggNOG; KOG1339; Eukaryota.
DR   GeneTree; ENSGT00940000153747; -.
DR   HOGENOM; CLU_013253_3_0_1; -.
DR   InParanoid; F1RIC8; -.
DR   TreeFam; TF314990; -.
DR   Proteomes; UP000008227; Chromosome 2.
DR   Bgee; ENSSSCG00000013098; Expressed in lymph node.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   Gene3D; 6.10.140.60; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          74..383
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        92
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        275
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        105..110
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        266..270
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        308..342
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   386 AA;  44135 MW;  D7AABF7C74402D17 CRC64;
     RVWVIVFHLL KMIELRIPLM KVKSIRENLR EKGLLENFLE EHPYDMIQNQ GSQNSTFKRK
     VIRHRLRNYF DMIYVGNITV GTPPQQFSVV FDTGSTDLWV PSVYCHSMAC VTHNIFDPFQ
     SSTFRFSATP IRLEYGSGMV SGFLGYDTVR IGRLIIMGQG FCITSWEESK TFEHAPFDGM
     LGLGYASLGI RGVTPVFDNI KRRGFLDQPV FAFYLSTKSE QGSVVIFGGV DHRYYRGDLR
     WVPLSKPHYW QIALDRISWR GYVIACKAGC QAIVDTGTSL LRGPNADVRN IQKLIGAHYF
     HREYVIRCSA PDTLPDIVFT INNVQYPVPA RAYIRKNTNG ICLSNFKGLI GHFNREAIWI
     LGDVFLRLYF TVFDRGQNRI GLATAV
//
DBGET integrated database retrieval system