ID F1RSQ1_PIG Unreviewed; 1112 AA.
AC F1RSQ1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Rho GTPase activating protein 39 {ECO:0000313|Ensembl:ENSSSCP00000006302.4};
GN Name=ARHGAP39 {ECO:0000313|Ensembl:ENSSSCP00000006302.4,
GN ECO:0000313|VGNC:VGNC:85475};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000006302.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000006302.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000006302.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000006302.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1RSQ1; -.
DR SMR; F1RSQ1; -.
DR STRING; 9823.ENSSSCP00000006302; -.
DR PaxDb; 9823-ENSSSCP00000006302; -.
DR Ensembl; ENSSSCT00000006473.5; ENSSSCP00000006302.4; ENSSSCG00000005894.5.
DR VGNC; VGNC:85475; ARHGAP39.
DR eggNOG; ENOG502QR6X; Eukaryota.
DR GeneTree; ENSGT00390000003161; -.
DR HOGENOM; CLU_005171_0_0_1; -.
DR InParanoid; F1RSQ1; -.
DR TreeFam; TF323577; -.
DR Reactome; R-SSC-8980692; RHOA GTPase cycle.
DR Reactome; R-SSC-9013026; RHOB GTPase cycle.
DR Reactome; R-SSC-9013106; RHOC GTPase cycle.
DR Reactome; R-SSC-9013148; CDC42 GTPase cycle.
DR Reactome; R-SSC-9013149; RAC1 GTPase cycle.
DR Reactome; R-SSC-9013404; RAC2 GTPase cycle.
DR Reactome; R-SSC-9013405; RHOD GTPase cycle.
DR Reactome; R-SSC-9013408; RHOG GTPase cycle.
DR Reactome; R-SSC-9013423; RAC3 GTPase cycle.
DR Reactome; R-SSC-9035034; RHOF GTPase cycle.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000005894; Expressed in uterus and 29 other cell types or tissues.
DR ExpressionAtlas; F1RSQ1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0099173; P:postsynapse organization; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04389; RhoGAP_KIAA1688; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF1; RHO GTPASE-ACTIVATING PROTEIN 39; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 63..97
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 720..872
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 919..1107
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1112 AA; 124815 MW; 1FE47258ACBBE7E7 CRC64;
MSQAQDYECE RHHGSLQESR GSGSSTRLEW VEIIEPRTRE RMYANLVTGE CVWDPPAGVR
IKRTSENQWW ELFDPNTSRF YYYNATTQRT VWHRPQDCDI IPLAKLQTLK QNTESPRASA
ENSPGRGSSV SRDGSTSSSL EPELEAGDRA QEPLGRAGRQ AALGAVKEES SSPSAAGVLP
EKDYEVYRDY SADGHLLHCR TSSLRWNSGT KERMLIKVAD REPSFLSPQG NGYPLDSQPG
GRPRRPSGGQ HSPSLQTFTP EADGPVFFSD RRPSPFLKRA ELGSCSPLLA QPRKPAGDSQ
PPSPRYAYEP LYEEPPVEYQ APIYDEPPMD VQYEAGGGYQ ASSPQRSPGR KPPKQASASP
YQQLVLTRQK CPERYLSLEY SPAGKEYVRQ LVYVEQAGSS PKLRTGPRHK YTPNPGGGSL
SLQPSPCLLR DQRLGITSGD YSSMEGPELR HTQLPTPLPQ AQDDAMSWSS QQDTMSSTGY
SPSTRKRKSR NPSLCHAPST SSTEGPGDRD LLSEQPLTEE RPLCGPSLAP TKRTEGKAGE
VDGARGVAEP FLAQARLAWE AQQAHLHMKQ RGSWDSQQDG SGYESDGAVP LPMPGPVVRA
FSEDEALAQQ ESKHWQRGAL DRLTFPQALL EKSVSVQTSL ASPEPYLHPS QSEDLGTCAQ
FESSRQARSV MPSASCVFPT FTLRKPSSET DIENWASKHF NKHTQGLFRR RVSIANMLAW
SSESIKKPMI VTSDRHVKKE ACEVFKLIQM YMGDRRAKAD PLHVALEIAT KGWSVQGLRD
ELYIQLCRQT TENFRLESLA RGWELMAICL AFFPPTPKFH SYLEGYIYRH MDPVNDTKVT
QHMKELLERN TKKKSKLRKK PKPYVEEPDG VAISTYAKYC YHKLQKAALT GAKKGLKKPN
VEEIRHAKNA VFSPSMFGSA LQEVMSMQKE RYPDRQLPWV QTRLSEEVLA LNGDQTEGIF
RVPGDIDEVN ALKLQVDQWK VPTGLEDPHV PASLLKLWYR ELEEPLIPHE FYEQCIAHYE
SPEAAVAVVH ALPRINRLVL CYLIRFLQVF VQPANVAVTK MDVSNLAMVM APNCLRCRSD
DPRVIFENTR KEMSFLRVLI QHLDTSFMEG VL
//
