ID F1RUR8_PIG Unreviewed; 1030 AA.
AC F1RUR8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Par-3 family cell polarity regulator {ECO:0000313|Ensembl:ENSSSCP00000011840.4};
GN Name=PARD3 {ECO:0000313|Ensembl:ENSSSCP00000011840.4,
GN ECO:0000313|VGNC:VGNC:95729};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000011840.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000011840.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000011840.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000011840.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR AlphaFoldDB; F1RUR8; -.
DR Ensembl; ENSSSCT00000012150.5; ENSSSCP00000011840.4; ENSSSCG00000011103.5.
DR VGNC; VGNC:95729; PARD3.
DR GeneTree; ENSGT00950000183214; -.
DR HOGENOM; CLU_006629_0_0_1; -.
DR TreeFam; TF323729; -.
DR Proteomes; UP000008227; Chromosome 10.
DR Bgee; ENSSSCG00000011103; Expressed in penis and 44 other cell types or tissues.
DR ExpressionAtlas; F1RUR8; baseline and differential.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 270..346
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 460..533
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 589..664
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 81..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..432
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..1014
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 113254 MW; 3A6F7F33C07597C5 CRC64;
MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD
LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGP NNVSAFQPYQ
ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SEEPSRKNPT RWSTTAGFLK
QNTAGNPTAC DRKKDENYRS LPRDTSNWSN QFQRDNARSS LSASHPMVDK WLEKQEQDED
GTEEDSSRVE PVGHADTGVE NVPNFSLDDM VKLVQVPNDG GPLGIHVVPF SARGGRTLGL
LVKRLEKGGK AEQENLFHEN DCIVRINDGD LRNRRFEQAQ HMFRQAMRTS IILFHVVPAA
NKEQYEQLSQ SERNNYYSSR FSPDSQYGDP RSVNSAGLQT LPRAPRPNPP PEHTDPLPRL
LPQGPQPSGK PRAPAPAAQN VFSSNLSSGY STKKVGKKLD IQLRKGTEGL GFSITSRDVT
IGGSAPIYVK NILPRGAAIQ DGRLKAGDRL IEVNGVDLAG KSQEEVVSLL RSTKMDGVVS
LLVYRQEDAF HPRELNAEPS QMQIPKETKA EDEDTVLTPD GTREFLTFEV PLNDSGSAGL
GVSVKGNRSK ENHADLGIFV KSIINGGAAS KDGRLRVDDQ LIAVNGESLL GKTNQDAMET
LRRSMSTEGN KRGMIQLIVA RRISKCAELK SPGSPSGPEL PIETVLDERE RRISHSLYSG
IEGLDESPTR NAALSRIMGK YQLSPTVNMP QDDTVIIEDD RLPVLPPHLS DQSSSSSHDD
VGFVTTDPST WAKAAITDSA DCSLSPDVDP VLAFQREGFG RQSMSEKRTK QFSDASQLDF
VKTRKSKSMD LGIADETKLN TVDDQKAGSP SRDVGPSLGL KKSSSLESLQ TAVAEVTLNG
DIPFHRPRPR IIRGRGCNES FRAAIDKSYD KPAVDDDDEG METLEEDTEE SSRSGRESVS
TASDQPSHSL ERQMNGNQER GDKTDRRKEK MGKEKKKDRD KEKEKMKAKK GKLRGLGDMF
SLAKLKPEKR
//
