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Database: UniProt
Entry: F1RVP8_PIG
LinkDB: F1RVP8_PIG
Original site: F1RVP8_PIG 
ID   F1RVP8_PIG              Unreviewed;       833 AA.
AC   F1RVP8; K9J6L7;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 3.
DT   22-NOV-2017, entry version 42.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|EMBL:JAA53769.1,
GN   ECO:0000313|Ensembl:ENSSSCP00000013706};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000013706, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000013706, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000013706};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000013706}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAA53769.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Dawson H.D., Chen C.T.;
RT   "Global Gene Expression Profiling of Alveolar Macrophages by Deep
RT   Sequencing.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AEMK02000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GACC01000038; JAA53769.1; -; mRNA.
DR   UniGene; Ssc.29794; -.
DR   STRING; 9823.ENSSSCP00000013706; -.
DR   PaxDb; F1RVP8; -.
DR   PeptideAtlas; F1RVP8; -.
DR   Ensembl; ENSSSCT00000014092; ENSSSCP00000013706; ENSSSCG00000012890.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; F1RVP8; -.
DR   OMA; WRACRGF; -.
DR   OrthoDB; EOG091G031W; -.
DR   TreeFam; TF300346; -.
DR   Reactome; R-SSC-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-SSC-6798695; Neutrophil degranulation.
DR   Reactome; R-SSC-77387; Insulin receptor recycling.
DR   Reactome; R-SSC-917977; Transferrin endocytosis and recycling.
DR   Proteomes; UP000008227; Chromosome 2.
DR   Bgee; ENSSSCG00000012890; -.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR   GO; GO:0007039; P:protein catabolic process in the vacuole; IEA:Ensembl.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F1RVP8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   833 AA;  93090 MW;  E7418A5FF414A96B CRC64;
     MGSMFRSEEV ALVQLFLPTA AAYTCVSQLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE
     LEKTFTFLQA EVRRAGLALP LPEGVLLAPP PRDLLRIQEE SDRLAQELRD VRGNQQALRA
     QLHQLQLHSA VLSQGHGHGP QLAATHTDMP LERTPLLQAP GGPHQDLRVN FVAGAVEPHK
     AAALERLLWR ACRGFLIASF RETEQQLEDP VTGEPATWTT FLISYWGEQI GQKIRKITDC
     FHCHVFPFAE QEEARLGALQ QLQQQSHELQ EVLGETERFL SQVLGRVQKL LPPWQVQIRK
     MKAVYLALNQ CSVSTTHKCL IAEAWCATRD LPTVQQALQD SSSEAGVSAV VHRIPCRDMP
     PTLVRTNRFT ASFQGIVDAY GVGRYQEVNP APYTIITFPF LFAVMFGDVG HGLLMFLFAL
     AMVLAENRPA VKTAQNEIWR TFFGGRYLLL LMGLFSVYTG FIYNECFSRA TAIFPSGWSV
     AAMANQSGWS DTFLAEHPLL TLDPNVTGVF LGPYPFGIDP VWSLAVNHLS FLNSFKMKMS
     VILGVTHMTF GVVLGVFNHM HFGQWHRLLL ETVPELVFLL ALFGYLVFLI VYKWLRFTAA
     DAASAPSVLL HFINMFLFSR SATNRPLFPG QEVVQSVLVV LALAMVPILL LGTPLFLRQQ
     HRRHARRRQL VEDEDKTGLL DASVSVSSQG LDEEKAECPG DREEAEFVAS EVFMHQAIHT
     IEFCLGCISN TASYLRLWAL SLAHAQLSEV LWAMVMRVGL GLSDEMGVVA VVLVPIFAAF
     AVMTVAILLV MEGLSAFLHA LRLHWVEFQN KFYAGTGYKL SPFTFAVEDA EHP
//
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