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Database: UniProt
Entry: F1RVP8_PIG
LinkDB: F1RVP8_PIG
Original site: F1RVP8_PIG 
ID   F1RVP8_PIG              Unreviewed;       844 AA.
AC   F1RVP8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 2.
DT   07-JUN-2017, entry version 40.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSSSCP00000013706};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000013706, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000013706, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000013706};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000013706}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSSCP00000013706}.
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DR   EMBL; CU856479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000013706; -.
DR   PaxDb; F1RVP8; -.
DR   PeptideAtlas; F1RVP8; -.
DR   Ensembl; ENSSSCT00000014092; ENSSSCP00000013706; ENSSSCG00000012890.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; F1RVP8; -.
DR   OMA; WRACRGF; -.
DR   OrthoDB; EOG091G031W; -.
DR   TreeFam; TF300346; -.
DR   Reactome; R-SSC-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-SSC-6798695; Neutrophil degranulation.
DR   Reactome; R-SSC-77387; Insulin receptor recycling.
DR   Reactome; R-SSC-917977; Transferrin endocytosis and recycling.
DR   Proteomes; UP000008227; Chromosome 2.
DR   Bgee; ENSSSCG00000012890; -.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR   GO; GO:0007039; P:protein catabolic process in the vacuole; IEA:Ensembl.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F1RVP8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    408    433       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    471       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    522    540       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    547    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    585    603       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    610    629       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    641    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    778    802       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   844 AA;  93943 MW;  4EEB766F3341CC70 CRC64;
     MGSMFRSEEV ALVQLFLPTA AAYTCVSQLG ELGLVEFRDL NASVSAFQRR FVVDVRPPPT
     PVPRHAAFLQ AEVRRAGLAL PLPEGVLLAP PPRDLLRIQE ESDRLAQELR DVRGNQQALR
     AQLHQLQLHS AVLSQGHGHG PQLAATHTDM PLERTPLLQA PGGPHQDLRV NFVAGAVEPH
     KAAALERLLW RACRGFLIAS FRETEQQLED PVTGEPATWT TFLISYWGEQ IGQKIRKITD
     CFHCHVFPFA EQEEARLGAL QQLQQQSHEL QEVLGETERF LSQVLGRVQK LLPPWQVQIR
     KMKAVYLALN QCSVSTTHKC LIAEAWCATR DLPTVQQALQ DSSSVGRMPQ SEAGVSAVVH
     RIPCRDMPPT LVRTNRFTAS FQGIVDAYGV GRYQEVNPAP YTIITFPFLF AVMFGDVGHG
     LLMFLFALAM VLAENRPAVK TAQNEIWRTF FGGRYLLLLM GLFSVYTGFI YNECFSRATA
     IFPSGWSVAA MANQSGWSDT FLAEHPLLTL DPNVTGVFLG PYPFGIDPVW SLAVNHLSFL
     NSFKMKMSVL LGVTHMTFGV VLGVFNHMHF GQWHRLLLET VPELVFLLAL FGYLVFLIVY
     KWLRFTAADA ASAPSVLLHF INMFLFSRSA TNRPLFPGQE VVQSVLVVLA LAMVPILLLG
     TPLFLRQQHR RHARRRQLVE VGGDEDKTGL LDASVSVSSQ GLDEEKAECP GDREEAEFVA
     SEVFMHQAIH TIEFCLGCIS NTASYLRLWA LSLAHAQLSE VLWAMVMRVG LGLSDEMGVV
     AVVLVPIFAA FAVMTVAILL VMEGLSAFLH ALRLHWVEFQ NKFYAGTGYK LSPFTFAVED
     AEHP
//
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