ID F1S1T3_PIG Unreviewed; 369 AA.
AC F1S1T3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=TNFAIP3 interacting protein 3 {ECO:0000313|Ensembl:ENSSSCP00000009709.4};
GN Name=TNIP3 {ECO:0000313|Ensembl:ENSSSCP00000009709.4,
GN ECO:0000313|VGNC:VGNC:94277};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000009709.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000009709.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000009709.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000009709.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1S1T3; -.
DR Ensembl; ENSSSCT00000009966.5; ENSSSCP00000009709.4; ENSSSCG00000009100.5.
DR VGNC; VGNC:94277; TNIP3.
DR eggNOG; ENOG502RYDP; Eukaryota.
DR GeneTree; ENSGT00510000046908; -.
DR HOGENOM; CLU_052353_0_0_1; -.
DR TreeFam; TF351138; -.
DR Proteomes; UP000008227; Chromosome 8.
DR Bgee; ENSSSCG00000009100; Expressed in penis and 23 other cell types or tissues.
DR ExpressionAtlas; F1S1T3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR Gene3D; 1.20.5.990; Nemo cc2-lz domain - 1d5 darpin complex; 1.
DR InterPro; IPR032419; CC2-LZ_dom.
DR PANTHER; PTHR31882:SF2; TNFAIP3-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR31882; TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER; 1.
DR Pfam; PF16516; CC2-LZ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 218..312
FT /note="NF-kappa-B essential modulator NEMO CC2-LZ"
FT /evidence="ECO:0000259|Pfam:PF16516"
FT REGION 84..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 369 AA; 42948 MW; F4BFAFC680E4125D CRC64;
MIPRGRLLSK KEKHEEKLVM FTNQSEDSER CESMELDNKI CDLIERNASF DPKGVTPGAM
LSHKSLCPVK TPGKTASVAH FVPSTSRMSG AESSTEHAEC AQSSRRKNLN SLEQKIRSLE
KQRKELLEVN QQWDQQFRSM KELYEKKVAE LKTKLDAAEK VLGTLEKEQQ PSLRESGARS
DQTWEKLREE KEKESLSEEL HELKKENKLL KEKNVLANQK KQCYEYEIKR LNKALQDALN
RKFSSPEDCL GKCEMECSHE EMKTEMEVLK QQVQIYEEDF KKERSDRERL NQEKVELQKI
NQTSQSQLNK LNSQIKACKM EKEKLERQLK QMYFPTCNCG WNFHLRDPCV PTGPGAVQDL
QKHPLSPQK
//
