ID F1SAG9_PIG Unreviewed; 665 AA.
AC F1SAG9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Melanoma cell adhesion molecule {ECO:0000313|Ensembl:ENSSSCP00000016039.4};
GN Name=MCAM {ECO:0000313|Ensembl:ENSSSCP00000016039.4,
GN ECO:0000313|VGNC:VGNC:112575};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000016039.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000016039.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000016039.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000016039.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F1SAG9; -.
DR PeptideAtlas; F1SAG9; -.
DR Ensembl; ENSSSCT00000016482.4; ENSSSCP00000016039.4; ENSSSCG00000015116.6.
DR VGNC; VGNC:112575; MCAM.
DR GeneTree; ENSGT00940000155838; -.
DR TreeFam; TF330534; -.
DR Proteomes; UP000008227; Chromosome 9.
DR Bgee; ENSSSCG00000015116; Expressed in stomach and 42 other cell types or tissues.
DR ExpressionAtlas; F1SAG9; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11973:SF18; CELL SURFACE GLYCOPROTEIN MUC18; 1.
DR PANTHER; PTHR11973; CELL SURFACE GLYCOPROTEIN MUC18-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SAG9};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..665
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023845882"
FT TRANSMEM 581..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..271
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 273..359
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 373..453
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 460..539
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 68..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 73487 MW; 585901E841649B4B CRC64;
MGTSGLICAF LLASCCCCRR VAGVPGEAEK PAPELLEVEV GGTALLKCGP SHSQSNFSHV
DWFSVSAPEE GSRGGRQRPR PSRSPRTLTS SPQVHKEKPT LIFRVRQGQG QSEPGEYQHR
LHLQDKGTTL ALTHITPHDE RIFLCQGKRP RSQEHRVQLR VYKAPEEPTI QVNPLGISVN
SEEPEEVATC VGRNGYPLPQ VIWYKNGRPL KEEKNRVQIQ SFQIVESSGL YTLQSVLKAQ
LAKEDKDAQF YCELSYRLPS GNHMKESPEV MVPVFYPAER VWLEVEPEGM LKEGDRVEIR
CLADGNPPPH FSISKQNLST KEMEEESTDD NGILVLEPAQ KEHSGLYECQ GLDLETTVSL
LSDQQELLVN YVSDVRVSPA APESQEGSSL TLTCEAESNQ DLEFQWLREK TGKVLERGPV
LQLRNLKREE GGGYRCVASA PSVPGLNRTQ LVNVAIFGSP WMTLRERKIR VKENTMLNLS
CEASGHPRPS IIWNVDGTAS EQDQDPQTVL SILSVLVTPE LLETGAKCVA SNPLGENVTS
IILELDSNRT NSLSTSTFSP PARANSTSTE RKLPEPESKG VVIVAVTVCV LVLAVLGAVL
YFFYKKGKLP CGRSGKQEIT LPPSRKSEFV VEVKSDKLPE EMGLLQGSNG DKRAPGDQVR
MIKYC
//
