ID F1SAY9_PIG Unreviewed; 943 AA.
AC F1SAY9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=WD repeat domain 3 {ECO:0000313|Ensembl:ENSSSCP00000007174.3};
GN Name=WDR3 {ECO:0000313|Ensembl:ENSSSCP00000007174.3,
GN ECO:0000313|VGNC:VGNC:94913};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000007174.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000007174.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000007174.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000007174.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat WDR3/UTP12 family.
CC {ECO:0000256|ARBA:ARBA00038229}.
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DR AlphaFoldDB; F1SAY9; -.
DR SMR; F1SAY9; -.
DR STRING; 9823.ENSSSCP00000007174; -.
DR PaxDb; 9823-ENSSSCP00000007174; -.
DR Ensembl; ENSSSCT00000007369.4; ENSSSCP00000007174.3; ENSSSCG00000006727.4.
DR VGNC; VGNC:94913; WDR3.
DR eggNOG; KOG0306; Eukaryota.
DR GeneTree; ENSGT00940000153859; -.
DR HOGENOM; CLU_005318_0_1_1; -.
DR InParanoid; F1SAY9; -.
DR OMA; MQCLRTV; -.
DR OrthoDB; 168440at2759; -.
DR TreeFam; TF300427; -.
DR Reactome; R-SSC-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006727; Expressed in oocyte and 43 other cell types or tissues.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19853; WD REPEAT CONTAINING PROTEIN 3 WDR3; 1.
DR PANTHER; PTHR19853:SF0; WD REPEAT-CONTAINING PROTEIN 3; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 10.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF117289; Nucleoporin domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 8.
DR PROSITE; PS50294; WD_REPEATS_REGION; 7.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 103..144
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 145..186
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 187..228
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 411..451
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 492..526
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 587..628
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 629..670
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 671..703
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 805..907
FT /note="Small-subunit processome Utp12"
FT /evidence="ECO:0000259|Pfam:PF04003"
FT REGION 229..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 943 AA; 106370 MW; 5C036288448D5ECB CRC64;
MGLTKQYLRY VASAVFGLIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI
LQGLKHEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN VTFNGHKAAV TSLKYDQLGG
RLASGSKDTD IIVWDVINES GLYRLKGHKD AITQALFLRE KNLLVSSGKD TMVKWWDLDT
QHCFKTVVGH RTEVWGLVLV SEEKRLITGA SDSELRAWDI AYLEEIEDPE EPEPKKIKGS
SPRMQDTDET EDGTLEMDEA PEDRILTCRK AGSIMREGRD RVVNLAVDRT GRILACHGTD
SVLEVFRVLS IEEIQKKMDK KLKKARKKAK LNSGKEEEED LEVSVEMTLQ DEIQRVTNIK
TSAKIKSFDL IHSPQGELKA VFLLQNNLVE LYSLNPSVPA SQPVRTSRIT IGGHRSDVRT
LSFSSDNIAV LSGAAESIKI WNRSTLQCIR TMTCEYALCS FFVPGDRQVV IGTKTGKLQL
YDLASGNLLE TVDAHDGALW SLSLSPDQRG FVTGGADKSV KFWDFELVKD ENSTQKRLSV
KQTRTLQLDE EVLCVSYSPN QKLLAVSLLD CTVKIFYVDT LKFFLSLYGH KLPVICMDIS
YDGALIATGS ADRNVKIWGL DFGDCHKSLF AHDDSVMYLK FVPKSHLFFT AGKDRKIKQW
DADKFEHVQT LEGHHQEIWC LAISPSGDYV VSSSHDKSLR LWERTREPLI LEEEREMQRE
AEYEESVAKE DQPAVPGETQ GDNYFTGKKT IETIKAAERI MEAIELYREE TAKMREHKAI
CKAAGKEVPL PINPILMAYG NISPSAYVLE IFKGIKSSEL EESLLVLPFS YVPDILKLFN
EFIQLGSDIE LLCRCLFFLL RIHFGQITSN QMLVPVIEKL KETTISKVSQ VRDVIGFNMA
GLDFLKRECE ARSEVMFFAD ATSHLEEKKR KRKKREKLIL TFT
//
