ID F1SDE4_PIG Unreviewed; 757 AA.
AC F1SDE4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 3.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 2 {ECO:0000313|Ensembl:ENSSSCP00000019107.3};
GN Name=TRPV2 {ECO:0000313|Ensembl:ENSSSCP00000019107.3,
GN ECO:0000313|VGNC:VGNC:94474};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000019107.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000019107.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000019107.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000019107.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013835803.1; XM_013980349.1.
DR AlphaFoldDB; F1SDE4; -.
DR PaxDb; 9823-ENSSSCP00000019107; -.
DR PeptideAtlas; F1SDE4; -.
DR Ensembl; ENSSSCT00000019627.5; ENSSSCP00000019107.3; ENSSSCG00000018032.5.
DR GeneID; 100523638; -.
DR KEGG; ssc:100523638; -.
DR CTD; 51393; -.
DR VGNC; VGNC:94474; TRPV2.
DR eggNOG; KOG3676; Eukaryota.
DR GeneTree; ENSGT00940000158512; -.
DR HOGENOM; CLU_012795_1_1_1; -.
DR OrthoDB; 1003028at2759; -.
DR TreeFam; TF314711; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000018032; Expressed in blood and 40 other cell types or tissues.
DR ExpressionAtlas; F1SDE4; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF5; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SDE4};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 393..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 162..194
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 294..317
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 397..648
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 85255 MW; 3CB95AE4DFBEDC79 CRC64;
MASPSSPPAF RLETSDRSRE DGAERDRGQP GGGARPPPME SAFQPEDRMF PPQITVDLHY
RKRAGASQPD PNRFDRDRLF RVVARGVPED LAGLPEYLRR TSKYLTDTEY REGSTGKTCL
MKAVLNLRDG ANACIQPLLQ IDRDSGNPQP LVNAQCTDAY YRGHSALHIA IEKRSLPCVK
LLVENGADVH ARACGQFFQK KSQDPCFYFG ELPLSLAVCT KQWDVVTYLL ENPHQSASPQ
AADSLGNTAL HALVAIADNS VKNTELVTLM YDKLLQAVAR LYPTVRLEDI PNLQGLTPLQ
LAAKEGKIEI FRHILQREFP GPCQSLSRKF TEWSYGPVRV SLYDLASVDS WEENSVLEII
AFHCRSSDRH RMVVLEPLNK LLQEKWNLLT PRFLINFLCY LIYVSVLTAV TYHQPALEKD
LLTLGNSTLL LGHILILLTG AYLLMGQLWY FWRRRLFIWT SFVDSYFEIL FLVQALLAVL
SQVLCFLAVK WYLPLLVSSL VLGWLNLLYY TRGLQHTGIY SVMIQKVILR DLLRFLLVYL
VFLFGFAVAL VSLSREAQAL GAPLGSNATE AAGEGDKEGS EALYKGILDA SLELFKFTIG
MGELAFQEQL RFRGVVLVLL LAYVLLTYVL LLNMLIALMS ETVNSVAHDS WSIWKLQKAI
CVLEMEKGYW WCRRKKQRAG VKLTVGTRPD GSPDERWCFR VEEVNWAAWE QTLPTVCEEP
SGPPGSSGDT NEPLASQPSQ DSVTEEDNVP LQPLESR
//
