ID F1SDY7_PIG Unreviewed; 1909 AA.
AC F1SDY7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 5.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=EMAP like 5 {ECO:0000313|Ensembl:ENSSSCP00000002627.5};
GN Name=EML5 {ECO:0000313|Ensembl:ENSSSCP00000002627.5,
GN ECO:0000313|VGNC:VGNC:87686};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000002627.5, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000002627.5, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000002627.5,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000002627.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR Ensembl; ENSSSCT00000002696.5; ENSSSCP00000002627.5; ENSSSCG00000002427.5.
DR VGNC; VGNC:87686; EML5.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000156613; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR TreeFam; TF317832; -.
DR Proteomes; UP000008227; Chromosome 7.
DR Bgee; ENSSSCG00000002427; Expressed in pituitary gland and 36 other cell types or tissues.
DR ExpressionAtlas; F1SDY7; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF16; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 11.
DR SMART; SM00320; WD40; 27.
DR SUPFAM; SSF50978; WD40 repeat-like; 5.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 4..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 233..264
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 330..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 381..440
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 665..715
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1227..1259
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1337..1395
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1689..1723
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1733..1813
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REGION 610..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1267..1293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..632
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1909 AA; 213322 MW; 48088A1AC1BD25FE CRC64;
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR EHRQKFYRGH
SDDIISLALH PERVLVATGQ VGKEPYICVW DSYTLQTISV LKDVHTHGIA CLAFDLDGQR
LVSVGLDSKN AVCVWDWKRG KMLSMAPGHT DRIFDISWDL YQPNKLVSCG VKHIKFWNLC
GNALTPKRGV FGKTGDLQTI LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHTAGI
FSMNACEEGF ATGGRDGCIR LWDLTFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
QDSEIFEIVV HERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR IWSLVDHALI
ARCNMEEPIR CAAVNVDGIH LALGMKDGSF TVLRVRDMTE VVHIKDRKEA IHELKYSPDG
TYLAVGCNDS SVDIYGVAQR YKKFGECVGS LSFITHLDWS SDSRYLQTND GNGKRLFYRM
PGGKEVTNKE EIKGVHWASW TCVSGLEVNG IWPKYSDIND INSVDGNYIG QVLVTADDYG
IVKLFRYPCL RKGAKFKKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
DALHIAPQES LADSNTDESD SDLSDVPELD SEIEQETQLT YRRQVYKEDL PQLKEQYKEK
QKSGTSKRRE RAPGNSIRLH FVHGYRGYDC RSNLFYTQIG EIVYHVAAVG VIYNRQQNTQ
RFYLGHDDDI LCLAIHPLKD YVATGQVGRD PTIHIWDTET IKPLSILKGY HQYGVCAVDF
SADGKRLVSV GIDDSHTIVL WDWKKGEKLS LARGSKDKIF VVKMNPYVPD KLITAGIKHM
KFWRRAGGGL IGRKGYVGTL GKNDTMMCAV YGWTEEMAFS GTSTGDVCIW RDVFLVKTVK
AHDGPVFSMH ALEKDGVVAL WDDSFERCLK TYAIKRAALA PGSKGLLLED NPSIRAISLG
HGHILVGTKN GEILEVDKSG PITLLVQGHM EGEVWGLATH PYLPICATVS DDKTLRIWDL
SPSHCMLAVR KLKKGGRCCC FSPDGKALAV GLNDGSFLMA NADTLEDLVS FHHRKDIISD
IRFSPGSGKY LAVASHDSFI DIYNVLSSKR VGVCKGATSY ITHIDWDIRG KLLQVNTGAK
EQLFFEAPRG KKQTIPSVEV EKIGWASWTS VLGLCCEGIW PVIGEVTDIT ASCLTSDKTV
LATGDDLGFV KLFRYPSKGK FGKFKRYVAH STHVTNVRWT YDDSMLVTLG GTDMSLMVWT
NEMEGYREKR PCDSEESDID SEEDGGYDSD VTRENETSYT IRALATNIRP MFGVKPHLQQ
KEPSVDERPP VSRAPPQPEK LQTNNVGKKK RPIEDLVLEL VFGYRGRDCR NNVHYLNDGD
DIIYHTASVG ILHNVATGTQ SFYQEHNDDI LCLTVNQHPK FINIVATGQV GDSADMSATA
PSIHIWDAMN KQTLSILRCY HSKGVCSVSF SATGKLLLSV GLDEHTITIW RWQEGAKIAS
RAGHNQRIFV AEFRPDSDSQ FVSVGVKHVK FWTLAGRTLL SRKGLLSTLD DARMQTMLAV
AFGANNLTFT GTISGDVCVW KDHILCRIVA RAHNGPVFAM YTTLRDGLIV TGGKERPSKE
GGAVKLWDQE LRRCRAFKLE TGQVTDCVRS VCRGKGKILV GTRNAEIIEV GEKNAACNIL
VNAHVDGPIW GLAAHPSRDF FLSAAEDGTV RLWDIADKKM LNKVNLGHAA RTVCYSPEGD
MVAIGMKNGE FIILLVSSLK IWGKKRDRRC AIHDIRFSPD SRFLAVGSSE NSVDFYDLTL
GPTLNRISYC KDIPSFVIQM DFSADSRHLQ VSTGCYKRHV YEVPSGKHLM DQTAIDRITW
ATWTAKHKRF LGHSPHVTNI RFTSGDRHVI SAGGDDCSLF VWRCVHMPH
//
