ID F1SF45_PIG Unreviewed; 1172 AA.
AC F1SF45;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Laminin subunit beta 3 {ECO:0000313|Ensembl:ENSSSCP00000016558.4};
GN Name=LAMB3 {ECO:0000313|Ensembl:ENSSSCP00000016558.4,
GN ECO:0000313|VGNC:VGNC:89622};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000016558.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000016558.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000016558.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000016558.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; F1SF45; -.
DR SMR; F1SF45; -.
DR STRING; 9823.ENSSSCP00000016558; -.
DR Ensembl; ENSSSCT00000017012.4; ENSSSCP00000016558.4; ENSSSCG00000015618.4.
DR VGNC; VGNC:89622; LAMB3.
DR GeneTree; ENSGT00940000160731; -.
DR HOGENOM; CLU_001560_0_0_1; -.
DR InParanoid; F1SF45; -.
DR ChiTaRS; LAMB3; pig.
DR Proteomes; UP000008227; Chromosome 9.
DR Bgee; ENSSSCG00000015618; Expressed in lung and 29 other cell types or tissues.
DR GO; GO:0043256; C:laminin complex; IBA:GO_Central.
DR GO; GO:0005610; C:laminin-5 complex; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0070831; P:basement membrane assembly; IBA:GO_Central.
DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd22303; cc_LAMB3_C; 1.
DR CDD; cd00055; EGF_Lam; 6.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF268; LAMININ SUBUNIT BETA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 6.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 6.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1172
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023837191"
FT DOMAIN 22..249
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 250..315
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 316..378
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 379..430
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 431..480
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 481..533
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 534..580
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 846..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1043..1070
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 281..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 346..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 401..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 453..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 481..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 483..500
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 502..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 534..546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 536..553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 555..564
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1172 AA; 129091 MW; 1647ED22D07DF5F5 CRC64;
MRLLLLLCFV LNSVLCTQQA CSRGACYPPV GDLLIGRTRF LRASSTCGLT KPETYCTQYD
EWKMKCCKCD SRLPHNYNSH RVENVISSSG PMRWWQSQND VNPVSLQLDL DSKFQLQAIT
MDFKGPMPAG LLIERSSDFG KTWRVYQYLA ADCTSAFPRV RQGQPQSWQD ARCQPLPQRP
DGRLDGAKVQ LKLMDLASGI QASQSQKIQE LGEITNLRVN FTRLAPLPQR GRHPPSAYYA
VSQLRLQGSC FCHGHADRCA PNPRAPAGPS TSVQVHEVCV CQHNTAGPNC ERCAPFYNNQ
PWSPAHDQDP HECQRCDCNG HSETCHFDPA VFAASQGTQG GVCDNCRDHT EGKNCERCQL
HYFRNRRPGA PIQETCIPCE CDPDGAVPGA PCDPVTGQCV CKEHVQGERC DLCKPGFTGL
TYANPQGCHR CDCSVLGARR DMPCDEESGR CLCLPHVVGP KCDQCAPHHW KLASGRGCEP
CACDPHNSLS PQCNQFTGQC PCREGFGGLT CSTAAIRLCP DRTYEDVATG CRACDCDFRG
TEGPGCDKAS GRCLCRPGLT GPRCDQCQRG YCDRYPVCVA CHPCFQTYDA GLQERALRLR
SLGNATASLR PGLGFEDLSL ASQMQDAKSK MEQIQAVLGG AVVTEREVAQ VAKAIFSLRQ
TLQALQPDLL PEEKTFLLPG DLENLDRNLN RLLVLYQSKK EQFEKISTAD PSGAFRMLSA
AYQRSSQATQ KVSDSSRLLL RLRDGRREAE GLVQQVVREA GAGGPQLVAL KLEMASLPDL
TSAINKLCGG SRQTPCTAGA CPGELCPRDN GTTCGSQCKG ALPRAGGAFR TAGQVAEQLR
GFNVQLQQTR QMIQAVEEAA SKVQADARRL ETQVSTSRTR MEEDVSRTQF LIQQVRDFLS
DPDTDAATIQ EVSEAVLALW LPTDSATVLR KMNEIQAIAA RLPNVDLVLS QTKQDIARAH
RLQAEAEQAR SRAHAAEGQL EDVVGNLQQG TVALQEAQDT MHGTRRSLQL IQDRVAEVQQ
VLGPAERLVM DRMEQLGGLR ARMEELSLQA RLQQAQAAQA RQLAEEASEQ ALSAQEGFER
IKQKYAELKD RLGRSPRLGE QGGRILSVKM EAEELFGEAV AMMDRMKDME SELLRGSQAI
LLRSADLTGL EKHVEQIRSY INERVLYYAT CK
//
