ID F1SH27_PIG Unreviewed; 661 AA.
AC F1SH27; A0A480Y0X7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=SKI like proto-onco {ECO:0000313|Ensembl:ENSSSCP00000012517.3};
DE SubName: Full=Ski-like protein isoform X1 {ECO:0000313|EMBL:HDC14335.1};
GN Name=SKIL {ECO:0000313|Ensembl:ENSSSCP00000012517.3,
GN ECO:0000313|VGNC:VGNC:92903};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000012517.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000012517.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000012517.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC14335.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000012517.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR EMBL; DQIR01258857; HDC14335.1; -; Transcribed_RNA.
DR EMBL; DQIR01258858; HDC14336.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000012517; -.
DR PaxDb; 9823-ENSSSCP00000012517; -.
DR Ensembl; ENSSSCT00000012857.5; ENSSSCP00000012517.3; ENSSSCG00000011746.5.
DR VGNC; VGNC:92903; SKIL.
DR eggNOG; ENOG502QT5P; Eukaryota.
DR GeneTree; ENSGT00940000158435; -.
DR HOGENOM; CLU_025786_0_0_1; -.
DR TreeFam; TF324133; -.
DR Reactome; R-SSC-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000011746; Expressed in caecum and 44 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0046332; F:SMAD binding; IBA:GO_Central.
DR GO; GO:0001825; P:blastocyst formation; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0070306; P:lens fiber cell differentiation; IEA:Ensembl.
DR GO; GO:0002260; P:lymphocyte homeostasis; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IBA:GO_Central.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:1902231; P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd21084; DHD_Sno; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.10.260.20; Ski; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR PANTHER; PTHR10005:SF3; SKI-LIKE PROTEIN; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 261..356
FT /note="c-SKI SMAD4-binding"
FT /evidence="ECO:0000259|SMART:SM01046"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 538..651
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 74668 MW; 5052DCB92C0FDFB4 CRC64;
MENLQTSFSL VQGSNKKLNG MGDDGSPPVK KMMTDIHANG KMIINKMPAV KKEHLDDYEA
PMETDEEHVK RTCASVPEPL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR YSQESMSPTV
FLPLPSPQVL PGPLLIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFSL
QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP
QNGSILPAKN SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRNG
KRTQSKIDAS PGMELQSWYP VIKQEGDHVS QTHSFLHPSY YLYMCDKVVA PNVSLTSAVS
QPKEVTKTEA SRSIPRQSEK PHSSGKHPKT VSYPDVSLEE QEKMDLKTNR ELYSRLDPSV
SNNSTSKKKP ESTTCCLARD ASKAGNDCDA AASSPLLVKD VICEDDKGKI MEEVMRTYVK
QQEKLNSILQ KKQQLQMEVE MLSSSKAMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ
KDLEKKLEQL AELRQRLDHA EADRQELQDE LRQEREARQK LEMMIKELKL QILKSSKTAK
E
//
