ID F1SIM8_PIG Unreviewed; 708 AA.
AC F1SIM8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Leucine rich repeat neuronal 3 {ECO:0000313|Ensembl:ENSSSCP00000017640.2};
DE SubName: Full=Leucine-rich repeat neuronal protein 3 {ECO:0000313|EMBL:HCZ74601.1};
GN Name=LRRN3 {ECO:0000313|Ensembl:ENSSSCP00000017640.2,
GN ECO:0000313|VGNC:VGNC:89862};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000017640.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000017640.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000017640.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HCZ74601.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000017640.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01019126; HCZ74601.1; -; Transcribed_RNA.
DR RefSeq; XP_003134818.1; XM_003134770.3.
DR STRING; 9823.ENSSSCP00000017640; -.
DR PaxDb; 9823-ENSSSCP00000017640; -.
DR Ensembl; ENSSSCT00000018130.5; ENSSSCP00000017640.2; ENSSSCG00000016652.5.
DR GeneID; 100520161; -.
DR KEGG; ssc:100520161; -.
DR CTD; 54674; -.
DR VGNC; VGNC:89862; LRRN3.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160513; -.
DR HOGENOM; CLU_000288_18_18_1; -.
DR OMA; DKFYMHP; -.
DR OrthoDB; 3968250at2759; -.
DR TreeFam; TF334360; -.
DR Proteomes; UP000008227; Chromosome 18.
DR Bgee; ENSSSCG00000016652; Expressed in Ammon's horn and 40 other cell types or tissues.
DR Genevisible; F1SIM8; SS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24373:SF7; LEUCINE-RICH REPEAT NEURONAL PROTEIN 3; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..708
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116836"
FT TRANSMEM 628..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 421..514
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 523..617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 708 AA; 79170 MW; 4F49EE036333D793 CRC64;
MKDLPLQIHV LLGLAITTLV QAVDKKADCP QLCTCEIRPW FTPRSIYMEA STVDCNDLGL
LNFPARLPAD TQILLLQTNN IAKIESSIDF PVNLTGLDLS QNNLSSVTNI NIKKMPQLLS
VYLEENKLTE LPEKCLSGLS NLQELYINHN LLSTISPGAF IGLDNLLRLH LNSNRLQMIN
SKWFDALPNL EILMIGENPI IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES
ISFYDNRLIK VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY HGTVESLPNL
KEISIHSNPI RCDCVIRWIN MNKTNIRFME PDSLFCVDPP EFQGQNVRQV HFREMMEICL
PLIAPESFPS NLDLEAGSYV SLHCRATAEP QPEIYWVTPS GKKLLPNTLT DKFYVHSEGT
LDITGITPTE GGLYTCIATN LVGADLKSIM IKVDGSFPRD NNGSLNIKIK DVQAHSVLVS
WKASSKILKS SVKWTAFVKT ENARAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ
KSRKQCVNVT TKSLDPDQKG YEKSNTTTFM ACLGGFLGII GVICLFSCLS QEMNCDGGHS
YVRNYLQKPT FAFGELYPPL INLWETGKEK GTGLEVKATV IGVPTHMS
//
