ID F1SKH7_PIG Unreviewed; 622 AA.
AC F1SKH7; A0A287AZL6; A0A4X1W4U4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Rho guanine nucleotide exchange factor 25 {ECO:0000313|EMBL:HDC73539.1, ECO:0000313|Ensembl:ENSSSCP00000049410.2};
DE SubName: Full=Rho guanine nucleotide exchange factor 25 isoform X1 {ECO:0000313|EMBL:HDA31888.1};
GN Name=ARHGEF25 {ECO:0000313|Ensembl:ENSSSCP00000049410.2,
GN ECO:0000313|VGNC:VGNC:103216};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:HDC73539.1};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000049410.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000049410.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC73539.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000049410.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01076412; HDA31888.1; -; Transcribed_RNA.
DR EMBL; DQIR01096153; HDA51629.1; -; Transcribed_RNA.
DR EMBL; DQIR01316867; HDC72341.1; -; Transcribed_RNA.
DR EMBL; DQIR01318065; HDC73539.1; -; Transcribed_RNA.
DR EMBL; DQIR01320698; HDC76172.1; -; Transcribed_RNA.
DR RefSeq; XP_003126361.1; XM_003126313.4.
DR PaxDb; 9823-ENSSSCP00000000463; -.
DR Ensembl; ENSSSCT00000038624.3; ENSSSCP00000049410.2; ENSSSCG00000000435.5.
DR Ensembl; ENSSSCT00005056113.1; ENSSSCP00005034576.1; ENSSSCG00005034659.1.
DR GeneID; 100517400; -.
DR KEGG; ssc:100517400; -.
DR CTD; 115557; -.
DR VGNC; VGNC:103216; ARHGEF25.
DR eggNOG; KOG0689; Eukaryota.
DR GeneTree; ENSGT00940000160422; -.
DR HOGENOM; CLU_001356_6_0_1; -.
DR OrthoDB; 2906033at2759; -.
DR Proteomes; UP000008227; Chromosome 5.
DR Bgee; ENSSSCG00000000435; Expressed in forelimb bud and 43 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 202..378
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 28..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..609
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 68691 MW; 6E079B1ED958E185 CRC64;
MKPPDRPAPG RTDRILGVMG GMLRACALPG QEWPPKRSPL GPGAAEPESI CTERDQRDQR
GEREREVPAW ARLPESYSIA GSEGSISASA ASGLAAPSGP SSGLSSGPCS PGPPGPVSGL
RRWLDHSKHC LSVETEGDGG QAGPYENWML EPAPATGEEL PELTLLTTLL GGPQDKTQPP
EEETLSQASE NEEEQKKKAL ERSMYVLSEL VETEKMYVDD LGQIVEGYMA TMAAQGVPEN
LRGRDRIVFG NIQQIYEWHR DYFLQELQRC LKDPDWLAQL FIKHERRLHM YVVYCQNKPK
SEHVVSEFGD SYFEELRQQL GHRLQLNDLL IKPVQRIMKY QLLLKDFLKY YSRAGMDTEE
LEQAVEVMCF VPKRCNDMMT LGRLRGFEGK LTAQGKLLGQ DTFWVTEPEA GGLLSSRGRE
RRVFLFEQIV IFSEALGGGV RGGTQPGYVY KSSIKVSCLG LEGNLQGDPC RFALTSRGPE
GGIQRYVLQT ADPAVSQAWI KQVAQILESQ RDFLNALQSP IEYQRRESQT NSLGRPGGPR
VGSPGRIRPG DQAQVSTHTP INGSLPSLLL LPEGEVARAP PPLDTQALSD IPQAPHDSPP
VPPIPNTPPC QARLAKLDED EL
//
