ID F1SLI4_PIG Unreviewed; 1173 AA.
AC F1SLI4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 4.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=ATP-dependent RNA helicase DHX30 {ECO:0000256|ARBA:ARBA00039388};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=DEAH box protein 30 {ECO:0000256|ARBA:ARBA00042917};
GN Name=DHX30 {ECO:0000313|Ensembl:ENSSSCP00000012095.4,
GN ECO:0000313|VGNC:VGNC:87289};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000012095.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000012095.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000012095.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000012095.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000256|ARBA:ARBA00004436}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR RefSeq; XP_013837077.1; XM_013981623.1.
DR AlphaFoldDB; F1SLI4; -.
DR PeptideAtlas; F1SLI4; -.
DR Ensembl; ENSSSCT00000012419.5; ENSSSCP00000012095.4; ENSSSCG00000011342.5.
DR GeneID; 100518989; -.
DR CTD; 22907; -.
DR VGNC; VGNC:87289; DHX30.
DR GeneTree; ENSGT00940000158279; -.
DR HOGENOM; CLU_001832_1_2_1; -.
DR OrthoDB; 1095660at2759; -.
DR TreeFam; TF352030; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000011342; Expressed in testis and 43 other cell types or tissues.
DR ExpressionAtlas; F1SLI4; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:Ensembl.
DR GO; GO:0035770; C:ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:1902775; P:mitochondrial large ribosomal subunit assembly; IEA:Ensembl.
DR CDD; cd17976; DEXHc_DHX30; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF257; ATP-DEPENDENT RNA HELICASE DHX30; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023271};
KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1SLI4};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 423..591
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 633..806
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 131222 MW; 411FB936377E8B8A CRC64;
MDPKRRGSGT GAPAPAPAGI ASRDLLKEFP QPKNLLNSVI GRALGISHAK DKLVYVHTNG
PKKKKVTLHI KWPKSVEVEG YGSKKIDAER QAAAAACQLF KGWGLLGPRN ELFDAAKYRV
LADRFGSPAD SWWRPEPTMP PTSWRQLNPE SIRPGGPAGL SRTLGREEEE DEEEELEEGT
IDVTEFLSMT QQDSHTPLRD SRGGSFEMTD DDSAIRALTQ FPLPKNLLAK VIQIATSSST
AKNLMQFHTV GTKTKLSTLT LLWPCPMTFV AKGRRKAEAE NKAAALACKK LKSLGLVDRN
NEPLTHAMYN LASLRELGET QRRPCTIQVP EPILRKIETF LNHYPVDNSW ISPELRLQGD
DILPLGKDSG PLSDPITGKP YVPLSEAEEL RLSQNLLELW RRRGPVWQEA PQLPVDPHRD
TILNAIEQHP VVVIAGDTGC GKTTRIPQLL LERYVTEGRG ARCNVIITQP RRISAVSVAQ
RVSHELGPSL RRNVGFQVRL ESKPPARGGA LLFCTVGILL RKLQSNPSLE GVSHVIVDEV
HERDVNTDFL LILLKGLQRL NPALRLVLMS ATGDNERFSR YFGGCPVIKV PGFMYPVKEH
YLEDILAKLG KHQYPHRHRH HESEDECALD LDLVTDLVLH IDARGEPGGI LCFLPGWQEI
KGVQQRLQEA LGMHESKYLI LPVHSNIPMM DQKAIFQQPP VGVRKIVLAT NIAETSITIN
DIVHVVDSGL HKEERYDLKT KVSCLETVWV SRANVIQRRG RAGRCQSGFA YHLFPRSRLE
KMVPFQVPEI LRTPLENLVL QAKIHMPEKT AVEFLSKAVD SPNIKAVDEA VILLQEIGVL
DQREYLTTLG QRLAHISTDP RLAKAIVLAA IFRCLHPLLV VVSCLTRDPF SSSLQNRAEV
DKVKALLSHD SGSDHLAFVR AVSGWEEVLR WQDRSSRENY LEENLLYAPS LRFIHGLIKQ
FSENIYEAFL VGKPSDCTLA SAQCNEYSEE EELVKGVLMA GLYPNLIQVR QGKVTRQGKF
KPNSVTYRTK SGNILLHKST INREATRLRS RWLTYFMAVK SNGSVFVRDS SQVHPLAVLL
LTDGDVHIRD DGRRATISLS DSDLLRLEGD SRTVRLLREL RRALGRMVER SLRSELATLP
PCVQQEHGQL LALLAELLRG PCGSFDVRKT ADD
//