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Database: UniProt
Entry: F1T5R5_9ACTN
LinkDB: F1T5R5_9ACTN
Original site: F1T5R5_9ACTN 
ID   F1T5R5_9ACTN            Unreviewed;       567 AA.
AC   F1T5R5;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   05-JUL-2017, entry version 42.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=HMPREF0091_10146 {ECO:0000313|EMBL:EGF23199.1};
OS   Atopobium vaginae DSM 15829.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Atopobiaceae; Atopobium.
OX   NCBI_TaxID=525256 {ECO:0000313|EMBL:EGF23199.1, ECO:0000313|Proteomes:UP000005947};
RN   [1] {ECO:0000313|EMBL:EGF23199.1, ECO:0000313|Proteomes:UP000005947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15829 {ECO:0000313|EMBL:EGF23199.1,
RC   ECO:0000313|Proteomes:UP000005947};
RA   Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G.,
RA   Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W.,
RA   Liu X., Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J.,
RA   Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D.,
RA   Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A.,
RA   Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L.,
RA   Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.,
RA   Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D.,
RA   Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R.,
RA   San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S.,
RA   Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K.,
RA   Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGF23199.1}.
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DR   EMBL; ACGK02000001; EGF23199.1; -; Genomic_DNA.
DR   RefSeq; WP_006302256.1; NZ_ADNA01000042.1.
DR   STRING; 525256.AvagD15_010100003374; -.
DR   EnsemblBacteria; EGF23199; EGF23199; HMPREF0091_10146.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000005947; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005947};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005947}.
FT   DOMAIN      243    385       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      475    544       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   567 AA;  64988 MW;  E7199406DC12B0AF CRC64;
     MSKEITTSDI QTTEHDMSDA YSLWQDVINL FREDGYIPSV IAMLEKCTLV SFTHNVLTIS
     TSLNFAYKKL TTHKDAIVAK MEEAAFEPIS LQILFKPFNN DVLNESNTAH VNNQTYVVQT
     SQESATTQPS HQVKTDEPTV QNANEASDKL INVQTQITKD ELDKLESQDN VLIDQYFDQM
     KTSHMERLNR DHKIISFETG QVENTVQSEI DSKLTFDRFV QGEENQLAYQ AANQVACGSC
     NQSYNPLFIY GKSGLGKTHL LRAIQNYIIK NDPTRTCAYK TATEFIEEYT LAWQKSPLER
     NALARSYKNI DVLIIDDIQN MRTAAGTIKF FFDTFNSLIS NGKQIVCAAD RSPQELQLGE
     SKFDERETSR MDSGITISIQ VPNYELKLNL INNFYKYIRH DAEVEHLLID FGTITEEQRM
     YMAKIAGSNI RVIEGFVQTC LINAGKRKKE GRIFSNNDIA QIAATKWKPR QHIPTIEEIQ
     KCIEDTYHIS HNDLVGDHRN KELTEPRHIC IWLARELTDI TLADIGQKFG NRTHATIKHS
     IAIIEKKKKD RVFYDQLQKL KDILTKE
//
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