ID F2IEA3_FLUTR Unreviewed; 693 AA.
AC F2IEA3;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Oxygen sensor histidine kinase NreB {ECO:0000256|ARBA:ARBA00017322};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
DE AltName: Full=Nitrogen regulation protein B {ECO:0000256|ARBA:ARBA00030800};
DE Flags: Precursor;
GN OrderedLocusNames=Fluta_0413 {ECO:0000313|EMBL:AEA42421.1};
OS Fluviicola taffensis (strain DSM 16823 / NCIMB 13979 / RW262).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Crocinitomicaceae; Fluviicola.
OX NCBI_TaxID=755732 {ECO:0000313|EMBL:AEA42421.1, ECO:0000313|Proteomes:UP000007463};
RN [1] {ECO:0000313|EMBL:AEA42421.1, ECO:0000313|Proteomes:UP000007463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16823 / RW262 / RW262 {ECO:0000313|Proteomes:UP000007463};
RX PubMed=22180807; DOI=10.4056/sigs.2124912;
RA Woyke T., Chertkov O., Lapidus A., Nolan M., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Huntemann M., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Rohde M.,
RA Mwirichia R., Sikorski J., Tindall B.J., Goker M., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of the gliding freshwater bacterium Fluviicola
RT taffensis type strain (RW262).";
RL Stand. Genomic Sci. 5:21-29(2011).
RN [2] {ECO:0000313|Proteomes:UP000007463}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16823 / RW262 / RW262 {ECO:0000313|Proteomes:UP000007463};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Pagani I.,
RA Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B.,
RA Pomrenke H.G., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Fluviicola taffensis DSM 16823.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Member of the two-component regulatory system NreB/NreC
CC involved in the control of dissimilatory nitrate/nitrite reduction in
CC response to oxygen. NreB functions as a direct oxygen sensor histidine
CC kinase which is autophosphorylated, in the absence of oxygen, probably
CC at the conserved histidine residue, and transfers its phosphate group
CC probably to a conserved aspartate residue of NreC. NreB/NreC activates
CC the expression of the nitrate (narGHJI) and nitrite (nir) reductase
CC operons, as well as the putative nitrate transporter gene narT.
CC {ECO:0000256|ARBA:ARBA00024827}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP002542; AEA42421.1; -; Genomic_DNA.
DR RefSeq; WP_013685195.1; NC_015321.1.
DR AlphaFoldDB; F2IEA3; -.
DR STRING; 755732.Fluta_0413; -.
DR KEGG; fte:Fluta_0413; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG4585; Bacteria.
DR HOGENOM; CLU_397279_0_0_10; -.
DR OrthoDB; 9778366at2; -.
DR Proteomes; UP000007463; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF37; SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE_PHOSPHATASE UHPB; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEA42421.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000007463};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 430..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 116..149
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 498..693
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 693 AA; 79207 MW; BA195FC11690E8CA CRC64;
MKIGVILFLL VTGTCFCQDI GELSNKFTQS KTKHLKMVYA SELAWKWRNI NPDSSFRYGK
IALNISRKLG DKKTEAYSLS DIGSYYKHIE QYKRSYYYLM ESLRIRKRIG ISKDIASSHN
QLGLLFKQQE RFDSAIVHFQ KGIQTLTHDQ QSMKGSLIDG LGMCFMHIGK FQKALFYVSQ
SLRIAEHLND SLSIGQSHQN LGVIYEKQGA PRLALVEFKT AERIYSGLKN QNGIFESIIN
QATVYQQLGE ISKADTHFIR AEDLCHKINF LDYLPTIWFN RAELYLEKDP ERSLLLYKLV
FQNANSGDKN VLKVSSMLGL MDASIRSKKL DDATYWKAQL EKNTPLSSLS LRKDFMDLCI
KYSQMKGDFE SAFRYNQDYI RIRDSIDFLT LNNLETLSLL EKAQSKEKIS NEKLKRLKVA
EKAKENQTRM WLIIMFIVMI LLSVSVLTMA LIYKMRLEKK RNELNEQQLQ QEMTDLVHGS
DLRVLEESLN VESKTRKDIG KDLHDNLGSK LAVVQIMLES FRKKTQDSSN ETQEKLLTAI
QLVDDSCNDL RTISRNLVNI RVNETGLIDS IAALCNNITE NTALRVAFQS EKEPLLSNVT
SRKDILATIS LLIHNILCHS EATEAEVILE GSEEQLSIIV RDNGIGFDQN TLKHAEGIGL
QNARERIEAM QGTIKVLSEK GNGTTIFIQL PII
//
