ID F2J3Y7_POLGS Unreviewed; 308 AA.
AC F2J3Y7;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase (Hdb-1) {ECO:0000313|EMBL:ADZ68969.1};
GN OrderedLocusNames=SL003B_0536 {ECO:0000313|EMBL:ADZ68969.1};
OS Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Polymorphum.
OX NCBI_TaxID=991905 {ECO:0000313|EMBL:ADZ68969.1, ECO:0000313|Proteomes:UP000008130};
RN [1] {ECO:0000313|EMBL:ADZ68969.1, ECO:0000313|Proteomes:UP000008130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 25793 / CGMCC 1.9160 / SL003B-26A1
RC {ECO:0000313|Proteomes:UP000008130};
RX PubMed=21478361; DOI=10.1128/JB.00333-11;
RA Li S.G., Tang Y.Q., Nie Y., Cai M., Wu X.L.;
RT "Complete genome sequence of Polymorphum gilvum SL003B-26A1T, a crude oil-
RT degrading bacterium from oil-polluted saline soil.";
RL J. Bacteriol. 193:2894-2895(2011).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
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DR EMBL; CP002568; ADZ68969.1; -; Genomic_DNA.
DR RefSeq; WP_013651293.1; NC_015259.1.
DR AlphaFoldDB; F2J3Y7; -.
DR STRING; 991905.SL003B_0536; -.
DR KEGG; pgv:SL003B_0536; -.
DR PATRIC; fig|991905.3.peg.549; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_0_1_5; -.
DR OrthoDB; 9803287at2; -.
DR Proteomes; UP000008130; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008130}.
FT DOMAIN 6..180
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 184..252
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 137
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 308 AA; 32723 MW; 88FFB67FDE6DAAF7 CRC64;
MRFDKTAVLG AGTIGMSWAA LFAATGREVA VFDPSPNAER RVLSTIEEVA DTLRALGFSH
AGEADRVRFT ADAAAAVEGA GFVQENVPER LDLKHGLYAR IEPVLGADAI VGSSTSGLRL
SDLQDGFSDP GRLVLAHPFN PPHLVPLVEL MANDRTDPGV VDTAQAFYEG MGKVCVRLRK
EVPGHIANRL QAALWREAIH LAVEGVASVE DIDKAVAFGP GLRWAAMGPN TLLHLGGGAG
GIRAFCAHLG GAFQSWWEDL GEPRLTPDVV DVLAEGVQAM VGETSPQELA ARRDRMILAC
LLAHARLS
//
