ID F2KMI0_ARCVS Unreviewed; 447 AA.
AC F2KMI0;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+)) {ECO:0000313|EMBL:AEA47177.1};
DE EC=1.1.1.40 {ECO:0000313|EMBL:AEA47177.1};
GN OrderedLocusNames=Arcve_1169 {ECO:0000313|EMBL:AEA47177.1};
OS Archaeoglobus veneficus (strain DSM 11195 / SNP6).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=693661 {ECO:0000313|EMBL:AEA47177.1, ECO:0000313|Proteomes:UP000008136};
RN [1] {ECO:0000313|EMBL:AEA47177.1, ECO:0000313|Proteomes:UP000008136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SNP6;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Lu M.,
RA Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of Archaeoglobus veneficus SNP6.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002588; AEA47177.1; -; Genomic_DNA.
DR RefSeq; WP_013683841.1; NC_015320.1.
DR AlphaFoldDB; F2KMI0; -.
DR STRING; 693661.Arcve_1169; -.
DR GeneID; 10394286; -.
DR KEGG; ave:Arcve_1169; -.
DR eggNOG; arCOG00853; Archaea.
DR HOGENOM; CLU_034446_2_1_2; -.
DR Proteomes; UP000008136; Chromosome.
DR GO; GO:0004473; F:malate dehydrogenase (decarboxylating) (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PIRSF; PIRSF000106; ME; 1.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:AEA47177.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008136}.
FT DOMAIN 27..160
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 172..405
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 447 AA; 49025 MW; 96A985411F0C068A CRC64;
MDKRTDTPIE KAKLPEKVAS EWHRFYGGKI EVLPKCVIRN LDDFSVWYTP GVAKPCEEIV
EDPDKAYDYT NKWNTVAVVS DGTRVLGLGD IGPLAALPVM EGKALLFKYL GGVDAFPVVL
NEKDPDKFIE IVKAISPSFG GINLEDISNP KCFYILDRLR EELDIPVWHD DQQGTATATL
AALLGALKVV GKKIEDVHIA IIGVGAANIA TIRLLTAAGA DPKKMYVVDS KGILHPGRKD
IEEKKDKNPY KWKYCLETNG EGRTGGMAEA IKGCDVLIAA SKPGPGVIKK EWIATMNDDA
IVFLEANPIP EMWPWEAKEA GARIVGTGRS DFPNQVNNSL VFPAVFRGVL DVRVRTITDE
MAIAAAKALV KCAERKGLSE DYVIPHMTDE GVFPEVATAT ALKAIEQGVA RLKLSREEIY
GRAESIINST QKKIRMLMEL GFIQPPP
//
